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(+/-)-Isorhynchophylline is an alkaloid compound derived from plant species such as Uncaria rhynchophylla and Uncaria tomentosa. It has been traditionally used in Chinese medicine due to its potential anti-inflammatory, antioxidant, and neuroprotective properties. Research has also indicated its potential therapeutic effects in treating cardiovascular diseases and neurological disorders, as well as its possible anti-cancer properties. This makes (+/-)-Isorhynchophylline a promising candidate for medicinal applications and ongoing research for its potential health benefits.

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  • 39032-62-7 Structure
  • Basic information

    1. Product Name: (+/-)-ISORHYNCHOPHYLLINE
    2. Synonyms: Corynoxan-16-carboxylicacid, 16,17-didehydro-17-methoxy-2-oxo-, methyl ester, (16E,20a)-(?à)- (9CI);Spiro[3H-indole-3,1'(5'H)-indolizine], corynoxan-16-carboxylic acid deriv.; (?à)-Isorhynchophylline
    3. CAS NO:39032-62-7
    4. Molecular Formula: C22H28N2O4
    5. Molecular Weight: 384.473
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 39032-62-7.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 560.8±50.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.23
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. PKA: 13.61±0.60(Predicted)
    10. CAS DataBase Reference: (+/-)-ISORHYNCHOPHYLLINE(CAS DataBase Reference)
    11. NIST Chemistry Reference: (+/-)-ISORHYNCHOPHYLLINE(39032-62-7)
    12. EPA Substance Registry System: (+/-)-ISORHYNCHOPHYLLINE(39032-62-7)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 39032-62-7(Hazardous Substances Data)

39032-62-7 Usage

Uses

Used in Traditional Chinese Medicine:
(+/-)-Isorhynchophylline is used as a traditional medicine ingredient for its potential anti-inflammatory, antioxidant, and neuroprotective properties.
Used in Cardiovascular Applications:
(+/-)-Isorhynchophylline is used as a therapeutic agent for treating cardiovascular diseases such as hypertension and arrhythmia, due to its potential beneficial effects on the cardiovascular system.
Used in Neurological Applications:
(+/-)-Isorhynchophylline is used as a potential treatment for neurological disorders, including Parkinson's disease and Alzheimer's disease, based on its neuroprotective properties.
Used in Anticancer Research:
(+/-)-Isorhynchophylline is used as a subject of investigation for its potential anti-cancer properties, with ongoing research exploring its health benefits in this area.

Check Digit Verification of cas no

The CAS Registry Mumber 39032-62-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,9,0,3 and 2 respectively; the second part has 2 digits, 6 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 39032-62:
(7*3)+(6*9)+(5*0)+(4*3)+(3*2)+(2*6)+(1*2)=107
107 % 10 = 7
So 39032-62-7 is a valid CAS Registry Number.

39032-62-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name (+/-)-ISORHYNCHOPHYLLINE

1.2 Other means of identification

Product number -
Other names Isorhyncophylline

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:39032-62-7 SDS

39032-62-7Downstream Products

39032-62-7Relevant articles and documents

Total synthesis of the spirocyclic oxindole alkaloids corynoxine, corynoxine B, corynoxeine, and rhynchophylline

Wanner, Martin J.,Ingemann, Steen,Van Maarseveen, Jan H.,Hiemstra, Henk

, p. 1100 - 1106 (2013/03/29)

Racemic total syntheses of four spirocyclic oxindole alkaloids are reported. The general starting material was an N-2-butenylated 2-hydroxytryptamine, which underwent a base-mediated Mannich spirocyclisation with a functionalised aldehyde to generate the C-ring. The second key step was a Pd-catalysed cyclisation of an α-keto ester enolate (in the original aldehyde) onto an allylic carbonate (in the N-substituent) to form the D-ring. The stereoselectivities of the key steps were moderate, but the isomers were readily purified, so that the natural products could be conveniently prepared, three of them for the first time. Racemic total syntheses of the four title spirocyclic oxindole alkaloids are reported starting from 4-hydroxytryptamine. The key steps were a base-mediated Mannich spirocyclisation to form the C-ring, and a Pd-catalysed cyclisation of a keto ester enolate onto an allylic carbonate to form the D-ring. Thus, convenient syntheses of the alkaloids were achieved, for three of them for the first time. Copyright

Process for the production of specific isomer mixtures from oxindole alkaloids

-

, (2008/06/13)

To produce defined isomer mixtures of compounds with spirocyclic beta-aminocarboxyl and/or beta-aminocarbonyl systems the invention supposes that they be dissolved in solvents which have good dissolving power for these compounds, whose relative permittivity is sufficient to stabilize the amphoteric intermediates occuring in isomerization, which as proton donors constitute hydrogen bridges, whose basicity is less than that of the compounds for isomerization and whose boiling point is so high that an adequate reaction speed can be attained by raising temperature. Further, the invention proposes that the isomerization be prevented, influenced, or terminated by altering at least one of these factors and or by altering the temperature.

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