- Syntheses of various 5-(bromoaryl)-substituted uracils
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The Suzuki Pd(0)-catalyzed coupling between arylboronic acids and aryl bromides or iodides in weakly alkaline medium, previously further developed by us, has been used for regioselective preparation of 5-(2'-bromo-5'-furyl)-, 5-(2'-bromo-4'-furyl)-, 5-(2'
- Wellmar,Hornfeldt,Gronowitz
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Read Online
- Preparation method of 2-amio-4-bromine pyrimidine
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The invention discloses a preparation method of 2-amio-4-bromine pyrimidine; the method takes uracil, phosphorus oxybromide, ammoniation reagent, and others as the raw material; through two-step reactions, the target product 2-amio-4-bromine pyrimidine can be prepared. The preparation method is simple in operation, convenient to purify, high in yield, low in cost, and suitable for industrial scaled production.
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Paragraph 0017; 0018; 0019; 0025; 0026; 0027; 0032-0034
(2017/08/29)
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- Regio- and chemoselective multiple functionalization of pyrimidine derivatives by selective magnesiations using TMPMgCl·LiCl
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(Chemical Equation Presented) Successive regio- and chemoselective magnesiations of pyrimidines using TMPMgCl·LiCl furnish, after trapping with various electrophiles, highly functionalized derivatives in good to excellent yields. Applications to the synth
- Mosrin, Marc,Knochel, Paul
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supporting information; experimental part
p. 2497 - 2500
(2009/05/30)
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- Metalation of bromodiazines. Diazines XL
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The syntheses of 2-bromopyrazine, 2,4-dibromopyrimidines, and 3-bromo-6-phenylpyrazine were improved and their metalation with lithium alkylamides was studied.
- Decrane, Laurence,Pie, Nelly,Turck, Alain
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p. 509 - 513
(2007/10/03)
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- Arylation of halogenated pyrimidines via a suzuki coupling reaction
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The Suzuki coupling reaction has been used extensively for the synthesis of a wide variety of unsymmetrical biaryl compounds. We have extended this reaction to demonstrate the utility of preparing monophenyl-, diphenyl-, or triphenylpyrimidine depending on the reaction conditions. Further, it has been shown that chloropyrimidine substrates are preferable over iodo-, bromo-, or fluoropyrimidines.
- Schomaker,Delia
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p. 7125 - 7128
(2007/10/03)
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- Flame-resistant polycarbonates containing units deriving from halogenated pyrimidine compounds in their polymer chain
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Flame-resistant thermoplastic branched polycarbonates of high molecular weight are prepared from: (1) a carbonate precursor; (2) at least one dihydroxyaromatic compound of formula: where:, R is a single bond, or a substituted or non-substituted linear or branched C1-C5 alkylene radical, or a group chosen from O, S, SO2 and CO;, X and Y, which may be the same or different, are H or CH3;, m and n, which may be the same or different, are whole numbers from 1 to 4; (3) at last one halogenated pyrimidine compound of formula: where: R2, R3, R4, which may be the same or different, are chlorine or bromine or hydrogen, on condition that at least one is chlorine or bromine;, R1 is chlorine or bromine, or a radical of formula: where Z is NH or S or O; (4) at least one polyfunctional organic compound as branching agent, characterized by possessing at least three equal or different groups chosen from the groups OH, COOH, COCl and SO2Cl.
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