3921-01-5

Basic information

• Product Name: 2,4-DIBROMOPYRIMIDINE
• Synonyms: 2,4-Dibromopyrimidine ,97%;2,4-Dibromopyrimidine;2,4-Dibromo-1,3-diazine
• CAS NO: 3921-01-5
• Molecular Formula: C₄H₂Br₂N₂
• Molecular Weight: 237.88
• Product Categories: Halides;Pyrazines, Pyrimidines & Pyridazines;Pyrimidine;Pyrazines, Pyrimidines & Pyridazines;Heterocycle-Pyrimidine series;alkyl bromide
• Mol File: 3921-01-5.mol

Chemical Properties

• Melting Point: 65-67 °C
• Boiling Point: 316.642°C at 760 mmHg
• Flash Point: 145.3°C
• Appearance: /
• Density: 2.197
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.615
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: -3.17±0.20(Predicted)
• CAS DataBase Reference: 2,4-DIBROMOPYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-DIBROMOPYRIMIDINE(3921-01-5)
• EPA Substance Registry System: 2,4-DIBROMOPYRIMIDINE(3921-01-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37
• HazardClass: IRRITANT, KEEP COLD, STORED UNDE
• Hazardous Substances Data: 3921-01-5(Hazardous Substances Data)

Usage

Chemical Properties

White power

InChI:InChI=1/C4H2Br2N2/c5-3-1-2-7-4(6)8-3/h1-2H

Upstream product

• 66-22-8 uracil 
• 3934-20-1 2,6-Dichloropyrimidine 
• 4595-60-2 2-bromopyrimidine 

Downstream Products

• 25095-48-1 2,4-diphenylpyrimidine 
• 10198-98-8 2-bromo-4-phenylpyrimidine 
• 1217024-37-7 C₁₂H₁₉BrN₂ 
• 663194-10-3 4-(4-bromopyrimidin-2-yl)morpholine 
• 1209459-32-4 4-(2-bromopyrimidin-4-yl)morpholine 
• 343926-69-2 2-amino-4-bromopyrimidine 

Relevant articles and documents

Syntheses of various 5-(bromoaryl)-substituted uracils

The Suzuki Pd(0)-catalyzed coupling between arylboronic acids and aryl bromides or iodides in weakly alkaline medium, previously further developed by us, has been used for regioselective preparation of 5-(2'-bromo-5'-furyl)-, 5-(2'-bromo-4'-furyl)-, 5-(2'

Preparation method of 2-amio-4-bromine pyrimidine

The invention discloses a preparation method of 2-amio-4-bromine pyrimidine; the method takes uracil, phosphorus oxybromide, ammoniation reagent, and others as the raw material; through two-step reactions, the target product 2-amio-4-bromine pyrimidine can be prepared. The preparation method is simple in operation, convenient to purify, high in yield, low in cost, and suitable for industrial scaled production.

Regio- and chemoselective multiple functionalization of pyrimidine derivatives by selective magnesiations using TMPMgCl·LiCl

(Chemical Equation Presented) Successive regio- and chemoselective magnesiations of pyrimidines using TMPMgCl·LiCl furnish, after trapping with various electrophiles, highly functionalized derivatives in good to excellent yields. Applications to the synth

Metalation of bromodiazines. Diazines XL

The syntheses of 2-bromopyrazine, 2,4-dibromopyrimidines, and 3-bromo-6-phenylpyrazine were improved and their metalation with lithium alkylamides was studied.

Arylation of halogenated pyrimidines via a suzuki coupling reaction

The Suzuki coupling reaction has been used extensively for the synthesis of a wide variety of unsymmetrical biaryl compounds. We have extended this reaction to demonstrate the utility of preparing monophenyl-, diphenyl-, or triphenylpyrimidine depending on the reaction conditions. Further, it has been shown that chloropyrimidine substrates are preferable over iodo-, bromo-, or fluoropyrimidines.

Flame-resistant polycarbonates containing units deriving from halogenated pyrimidine compounds in their polymer chain

Flame-resistant thermoplastic branched polycarbonates of high molecular weight are prepared from: (1) a carbonate precursor; (2) at least one dihydroxyaromatic compound of formula: where:, R is a single bond, or a substituted or non-substituted linear or branched C1-C5 alkylene radical, or a group chosen from O, S, SO2 and CO;, X and Y, which may be the same or different, are H or CH3;, m and n, which may be the same or different, are whole numbers from 1 to 4; (3) at last one halogenated pyrimidine compound of formula: where: R2, R3, R4, which may be the same or different, are chlorine or bromine or hydrogen, on condition that at least one is chlorine or bromine;, R1 is chlorine or bromine, or a radical of formula: where Z is NH or S or O; (4) at least one polyfunctional organic compound as branching agent, characterized by possessing at least three equal or different groups chosen from the groups OH, COOH, COCl and SO2Cl.