- PYRIDOXAL AMINOGUANIDINE DERIVATIVES AND THEIR SALTS AND PRODUCTION METHOD THEREOF
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PROBLEM TO BE SOLVED: To provide compounds which are good in absorptivity on oral administration, serve as hypoglycemic agents with high safety and are useful as inhibitors for AGE formation reactions and their production method. SOLUTION: A method of producing pyridoxal/aminoguanidine derivatives and their salts having a structure with the amino group of pyridine derivatives of formula (V) substituted with another group comprises reacting pyridoxal with one of 1-amino-3-propyl guanidine hydroiodide, 4-methyl-S-methylisothiosemicarbazide hydroiodide, 3-methylisosemicarbazide hydrochloride and morpholine-4-carboxyimide hydrazide hydroiodide. COPYRIGHT: (C)2015,JPO&INPIT
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Paragraph 0030; 0031
(2019/01/04)
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- Electronic properties of 3,3′-dimethyl-5,5'-bis(l,2,4-triazine): Towards design of supramolecular arrangements of N-heterocyclic Cui complexes
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A new efficient and safe synthesis of 3,3′-dimethyl-5,5′-bis- (1,2,4-triazine) is presented. The electron-density distribution and electrostatic properties (charge, electrostatic potential) of this molecule were analyzed. These properties were derived from a high-resolution single-crystal X-ray diffraction experiment at 100 K and compared to the results obtained from ab initio DFT quantum-mechanical calculations. Comparisons of its electrostatic potential features and integrated atomic charges (quantum theory of atoms in molecules, QTAIM) havebeen made with those of related molecules such as bipyrimidine ligands. Two methods were used to derive integrated charges: one is based on the conventional analytical procedure and the second uses a steepest-ascent numerical algorithm. Excellent agreement was obtained between these two methods. Charges and electrostatic potential were used as predictive indices of metal chelation and discussed in the light of complexation abilities of the title compound and related molecules. The crystal structure of a Cu I complex of 3,3′-dimethyl-5,5′-bis(1,2,4-triazine) is reported here. In the solid state, this complex forms a three-dimensional multibranch network with open channels in which counterions and solvent molecules are located. This architecture involves both cis and trans isomers of the title compound.
- Courcot, Blandine,Tran, Diem Ngan,Fraisse, Bernard,Bonhomme, Francois,Marsura, Alain,Ghermani, Nour Eddine
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p. 3414 - 3423
(2007/12/29)
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