- Preparation method of cefathiamidine hydrochloride
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The invention provides a preparation method of cefathiamidine hydrochloride. In particular, by adopting a reverse dropwise adding manner, the intermediate product vinylidene chloride is added dropwise to the ammonia methanol to generate stable cefathiamidine, and the reverse dripping mode not only effectively inhibits the decomposition of the aramidine, but also the yield of cefathiamidine hydrochloride can reach 95% or above. The method is safe to operate. The method is high in yield and low in energy consumption, and is very suitable for large-scale application.
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Paragraph 0039; 0062; 0066-0068; 0072-0074; 0078-0080; ...
(2021/09/01)
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- Synthesis, structures of some unsymmetrical 3,6-disubstituted-1,2,4,5- tetrazines
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(Chemical Equation Presented) A series of new unsymmetrical 3-phenyl-6-benzyl-1,2,4,5-tetrazine derivatives 10a-i were synthesized and characterized by IR, NMR, MS, and element analysis. The structures of 4a, 10c, 10d and 10h were analyzed by X-ray crystallography, which had intermolecular C-H...N, C-H...Cl, C-H...Π and Π...Π H interactions.
- Hu, Wei-Xiao,Xu, Feng
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scheme or table
p. 1745 - 1750
(2009/05/31)
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- Pyrazole derivatives
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This invention relates to pyrazole derivatives of formula (I) or pharmaceutically acceptable salts, solvates or derivatives thereof, and to processes for the preparation thereof, intermediates used in their preparation of, compositions containing them and the uses of such derivatives. The compounds of the present invention bind to the enzyme reverse transcriptase and are modulators, especially inhibitors thereof. As such, the compounds of the present invention are useful in the treatment of a variety of disorders including those in which the inhibition of reverse transcriptase is implicated. Disorders of interest include those caused by Human Immunodificiency Virus (HIV) and genetically related retroviruses, such as Acquired Immune Deficiency Syndrome (AIDS).
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