39562-58-8

Basic information

• Product Name: 4,4-dimethoxybutan-2-ol
• Synonyms: 4,4-dimethoxybutan-2-ol;4,4-Dimethoxy-2-butanol;3-Hydroxybutyraldehyde DiMethyl Acetal;Aldol dimethyl acetal
• CAS NO: 39562-58-8
• Molecular Formula: C₆H₁₄O₃
• Molecular Weight: 134.17356
• EINECS: 254-512-6
• Product Categories: Aliphatics, Intermediates, Miscellaneous Reagents
• Mol File: 39562-58-8.mol

Chemical Properties

• Boiling Point: 192.9°Cat760mmHg
• Flash Point: 70.5°C
• Appearance: /
• Density: 0.968g/cm³
• Vapor Pressure: 0.126mmHg at 25°C
• Refractive Index: 1.416
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 4,4-dimethoxybutan-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 4,4-dimethoxybutan-2-ol(39562-58-8)
• EPA Substance Registry System: 4,4-dimethoxybutan-2-ol(39562-58-8)

Safety Data

• Hazardous Substances Data: 39562-58-8(Hazardous Substances Data)

Usage

Uses

Used in Chemical Synthesis:
4,4-Dimethoxybutan-2-ol is used as an intermediate in the chemical synthesis of aldols and aldol polymerization. Its ability to form aldols, which are important in the construction of complex organic molecules, makes it a valuable compound in the field of organic chemistry. The aldol reaction is a fundamental carbon-carbon bond-forming process that allows for the creation of a wide range of chemical structures.
Used in Paper Industry:
In the paper industry, 4,4-Dimethoxybutan-2-ol is used in the synthesis of model polymers for paper wet strengthening. 4,4-Dimethoxybutan-2-ol contributes to the development of polymers that can enhance the strength and durability of paper when it is exposed to moisture. This application is particularly important for improving the performance of paper products in various environments and conditions.
Used in Pharmaceutical Industry:
Although not explicitly mentioned in the provided materials, 4,4-Dimethoxybutan-2-ol, due to its structural features, could potentially be used in the pharmaceutical industry as a building block for the synthesis of complex drug molecules. Its ability to form diverse chemical structures makes it a promising candidate for the development of new drugs with specific therapeutic properties.

InChI:InChI=1/C6H14O3/c1-5(7)4-6(8-2)9-3/h5-7H,4H2,1-3H3

Upstream product

• 67-56-1 methanol 
• 107-89-1 acetaldol 
• 5436-21-5 acetylacetaldehyde dimethyl acetal 
• 7653-39-6 paraldol 
• 34405-39-5 methyl orthoformate 
• 75-07-0 acetaldehyde 

Downstream Products

• 107-89-1 acetaldol 
• 95603-58-0 3-(Phenylmethoxy)-butanal dimethyl acetal 

Relevant articles and documents

PANTETHEINE DERIVATIVES AND USES THEREOF

The present disclosure relates to compounds of Formula (I), (II), or (II'): (I), (II), (II'), and pharmaceutically acceptable salts or solvates thereof. The present disclosure also relates to pharmaceutical compositions comprising the compounds and therapeutic and diagnostic uses of the compounds and pharmaceutical compositions.

Novel benzoxazolone compound

PROBLEM TO BE SOLVED: To provide a therapeutic agent for diseases such as neuropathic pain, nociceptive pain, inflammatory pain, small diameter fiber neuropathy, erythromelalgia, paroxysmal extreme pain disorder, dysuria or multiple sclerosis. SOLUTION: There is provided a benzoxazolone compound represented by the formula (1) or a pharmaceutically acceptable salt. (1), where R1 and R2 are each independently H or C1-6 alkyl, where the alkyl may be substituted by hydroxy, C1-4 alkylsulfonyl, aminocarbonyl or 4 to 7-membered heterocycloalkyl, or the like, L is C1-6 alkylene, R3 is C1-6 alkyl, C3-7 cycloalkyl, where the cycloalkyl may be substituted by halogen or hydroxy or the like, C6-10 aryl, where the aryl may be substituted by halogen, C1-4 alkyl or C1-4 haloalkyl or the like, R4 is H, halogen or C1-4 alkyl. SELECTED DRAWING: None COPYRIGHT: (C)2017,JPOandINPIT

α-Amino Acid-Isosteric α-Amino Tetrazoles

The synthesis of all 20 common natural proteinogenic and 4 otherα-amino acid-isosteric α-amino tetrazoles has been accomplished, whereby the carboxyl group is replaced by the isosteric 5-tetrazolyl group. The short process involves the use of the key Ugi tetrazole reaction followed by deprotection chemistries. The tetrazole group is bioisosteric to the carboxylic acid and is widely used in medicinal chemistry and drug design. Surprisingly, several of the common α-amino acid-isosteric α-amino tetrazoles are unknown up to now. Therefore a rapid synthetic access to this compound class and non-natural derivatives is of high interest to advance the field.

Reconstructed hydrotalcite as a highly active heterogeneous base catalyst for carbon-carbon bond formations in the presence of water

The aldol reaction of carbonyl compounds is efficiently catalyzed by reconstructed hydrotalcites, obtained by treating the Mg-Al mixed oxide with water, as solid base catalysts in the presence of water. The catalysis of the reconstructed hydrotalcites is attributable to the surface base sites, created during the organization of the layered structure, with uniformly distributed strength. Furthermore, the reconstructed hydrotalcites provide a unique acid-base bifunctional surface capable of promoting the Knoevenagel and Michael reactions of nitriles with carbonyl compounds.

Aldolase catalyzed stereoselective synthesis of arabinohexulose, xyloheptulose, threohexulose and xylohexulose

The present invention relates to aldolase catalyzed stereo-selective synthesis of sugars and compositions of matter comprising arabinohexulose, xyloheptulose, threohexulose, and xylohexulose.

Fructose 1,6-Diphosphate Aldolase Catalyzed Stereoselective Synthesis of C-Alkyl and N-Containing Sugars: Thermodynamically Controlled C-C Bond Formations.

Fructose 1,6-diphosphate aldolase catalyzed aldol condensations have been used in syntheses of several new N-containing and C-alkyl sugars on 4-20 mmol scales.The enzyme is highly specific for dihydroxyacetone phosphate as donor but accepts a number of achiral and chiral aldehydes (both D and L isomers) as acceptors.Due to the reversible nature of the aldol reaction, a thermodynamically controlled approach was employed for the syntheses in which racemic aldehydes were used as substrates and thermodynamically more stable products were preferentially produced.

Acyclic Stereoselection. 22. Diastereofacial Selectivity in the Lewis Acid Mediated Reactions of Allylsilanes with Chiral Aldehydes and Enones

The Lewis acid mediated reactions of chiral aldehydes 1-4 and enones 5-8 with allylsilanes 9 and 10 have been investigated.With aldehyde 1 and enones 5-7, modest diastereofacial preferences are seen, in the sense predicted by application of Felkin's model for asymmetric induction.Aldehydes 2-4 and enone 8 appear to react by way of chelated intermediates.With these four compounds, the diastereofacial preferences are rather large and are in the sense that is consistend with attack of the allylsilane on the least hindered face of the chelated intermediate.In the reaction of the trans and cis enones 6 and 8 with allyltrimethylsilane, a dramatic reversal of diastereofacial preference is observed; enone 6 gives a 84:14 ratio of products, while enone 8 provides a 10:90 mixture of the same products.