396725-72-7

Basic information

• Product Name: THIOCARBONIC ACID O-TERT-BUTYL ESTER S-(3-FORMYL-PHENYL) ESTER
• Synonyms: THIOCARBONIC ACID O-TERT-BUTYL ESTER S-(3-FORMYL-PHENYL) ESTER
• CAS NO: 396725-72-7
• Molecular Formula: C₁₂H₁₄O₃S
• Molecular Weight: 238.3
• Mol File: 396725-72-7.mol

Chemical Properties

• Boiling Point: 345.6±44.0 °C(Predicted)
• Appearance: /
• Density: 1.17±0.1 g/cm3(Predicted)
• CAS DataBase Reference: THIOCARBONIC ACID O-TERT-BUTYL ESTER S-(3-FORMYL-PHENYL) ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: THIOCARBONIC ACID O-TERT-BUTYL ESTER S-(3-FORMYL-PHENYL) ESTER(396725-72-7)
• EPA Substance Registry System: THIOCARBONIC ACID O-TERT-BUTYL ESTER S-(3-FORMYL-PHENYL) ESTER(396725-72-7)

Safety Data

• Hazardous Substances Data: 396725-72-7(Hazardous Substances Data)

Upstream product

• 323191-90-8 3-S-(t-butoxycarbonyl)mercaptobenzoic acid 
• 4869-59-4 3-mercapto benzoic acid 
• 24424-99-5 di-tert-butyl dicarbonate 
• 396725-71-6 3-S-(t-butoxycarbonyl)mercaptobenzyl alcohol 

Downstream Products

• 396725-73-8 2-phenyl-4-[3-S-(t-butoxycarbonyl)mercaptobenzyl]amino-3'-carboxybiphenyl 
• 396725-74-9 2-phenyl-4-(3-t-butoxycarbonylmercapto)benzylamino-3'-methoxycarbonylbiphenyl 

Relevant articles and documents

Design and synthesis of potent nonpeptidic farnesyltransferase inhibitors based on a terphenyl scaffold

By modification of key carboxylate, hydrophobic, and zinc-binding groups projected from a sterically restricted terphenyl scaffold, a series of simple and nonpeptide mimetics of the CysVal-Ile-Met tetrapeptide substrate of protein farnesyltransferase (FTase) have been designed and synthesized. A crystal structure of 4-nitro-2-phenyl-3′-methoxycarbonylbiphenyl shows that the triphenyl fragment provides a large hydrophobic surface that potentially mimics the hydrophobic side chains of the three terminal residues in the tetrapeptide. 2-Phenyl-3-(N-(1-(4-cyanobenzyl)-1H-imidazol-5-yl)methyl)amino- 3′carboxylbiphenyl, in which the free thiol group was replaced with a 1-(4-cyanobenzyl)imidazole group, shows submicromolar inhibition activity against FTase in vitro and inhibits H-Ras processing in whole cells.