- Synthesis of novel precursors of Pfitzinger reaction: A facile one-pot strategy to the synthesis of quinoline carboxylic acid derivatives of pyrazolo-carbazoles and azacarbazoles
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Interaction of 5-indazolyldiazonium chloride 2 with 2-hydroxymethylidene cyclohexanone 5 and N-benzyl-3-hydroxymethylidene-4-piperidone 6 under the conditions of Japp-Klingemann reaction, followed by Fischer-indolization of the resulting hydrazones, formed the 5,7,8,9-tetrahydropyrazolo[4,3-b]carbazol-6(1H) -one 9 and 9-benzyl-5,7,8,9-tetrahydropyrido[2′,3′:4,5]pyrrolo[2,3- f]indazol-6(1H)-one 10, respectively. Pfitzinger reaction of 9 and 10 with isatin in alkali afforded the corresponding quinoline carboxylic acid derivatives 12 and 13, respectively. [Figure not available: see fulltext.]
- Tyagi, Ruchi,Singh, Bhawani,Kishore
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scheme or table
p. 431 - 435
(2012/08/07)
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- Synthesis of bicyclic salicylates by [3+3] cyclization of 1,3-bis(silyl enol ethers) with cyclic 3-(silyloxy)alk-2-en-1-ones
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Bicyclic salicylates were prepared by [3+3] cyclization of 1,3-bis(silyl enol ethers) with cyclic 3-(silyloxy)alk-2-en-1-ones.
- H?tteckea, Nicole,Reinkea, Helmut,Fischerb, Christine,Langera, Peter
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experimental part
p. 699 - 706
(2009/12/26)
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- COMPOSITIONS AND METHODS FOR VIRAL INHIBITION
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The present invention discloses methods and compositions for viral inhibition, particularly inhibition of HCV and SARS. The invention also provides compositions including carbazole derivatives useful for viral inhibition.
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Page/Page column 30
(2010/02/11)
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- Formylation of o-silylated enolates by Vilsmeier's reagent
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Reaction of trimethylsilylenol ethers and Vilsmeier's reagent leads to the corresponding regiocontrolled β-dicarbonyl compounds with high to good yields.
- Jameleddine, Khiari,Bechir, Ben Hassine,Mustapha, Mhirsi
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p. 2759 - 2762
(2007/10/03)
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- THERMALLY INITIATED REACTIONS OF (Z)-EPOXYHEXENYNES A FACILE PREPARATION OF 3,4-ANNULATED FURANS
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An efficient and general access to 3,4-annulated 2-vinylfurans (type II) is provided by the thermally induced ring transformation of epoxyhexenynes (I).Depending on the substitution pattern the reactions proceed either by heating in solution (5a-h) or under short-time thermolysis conditions (6i, j).The results are consistent with a multistep mechanism involving 1-oxacyclohepta-3,4,6-trienes as central intermediates.
- Eberbach, Wolfgang,Roser, Joachim
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p. 2221 - 2234
(2007/10/02)
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- Alicyclic substituted oxazolidine-2,4-diones having hypoglycemic activity
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Hypoglycemic oxazolidine-2,4-diones, substituted at the 5-position with a (C5 -C9) unsaturated monocyclic, saturated bicyclic or unsaturated bicyclic hydrocarbon radical; methods for their preparation; and method for their use in the
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- 2-Hydroxymethylenecyclohexanones
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Processes and compositions for improving, modifying or enhancing the organoleptic properties of a tobacco product which comprises adding thereto an effective amount of a 2-hydroxymethylenecyclohexanone.
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- A Novel Cycloaromatization Reaction. Regiocontrolled Synthesis of Substituted Methyl Salicylates
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A new method of constructing six-membered rings, involving the condensation of two three-carbon units, one with two nucleophilic sites and the other containing two electrophilic sites, is reported.The regiochemistry of the reaction is controlled by the differential reactivities of these sites. 1,3-Bis(trimethylsiloxy)-1-methoxybuta-1,3-diene (1) constitutes the three-carbon fragment with two nucleophilic sites.Condensation of 1 with various equivalents of β-dicarbonyl compounds and titanium tetrachloride gave substituted methyl salicylates.The regiochemistry is controlled by the order of reactivity of the electrophilic sites, which is conjugate position of enone > ketone > monothioacetal, acetal.
- Chan, Tak-Hang,Brownbridge, Peter
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p. 3534 - 3538
(2007/10/02)
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- 5,6-Benzo analogues of prostaglandin E
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Disclosed are prostaglandin analogues having the structural formula, STR1 in which: T is selected from the group consisting of carboxyl, alkoxycarbonyl or cyano; M is selected from the group consisting of carbonyl, R-hydroxymethylene or S-hydroxymethylene; L is selected from the group consisting of methylene or methine, provided L is methine only if J is methine; J is selected from the group consisting of methylene, ethylene, R-hydroxymethylene, S-hydroxymethylene or methine, provided J is methine only if L is methine; W is selected from the group consisting of --CH2 --CH-- or trans --CH=C--; T1 and T2 are attached to adjacent carbon atoms; T1 is selected from the group consisting of hydrogen or phenyl, provided T1 is phenyl only if T2 is lower alkyl; T2 is selected from the group consisting of n-pentyl or lower alkyl, provided T2 is lower alkyl only if T1 is phenyl; Or T1 and T2 are joined together to form an alkylene group of 4 or 6 carbon atoms. Also disclosed are methods for preparing such prostaglandin analogues.
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- 5,6-Benzo analogues or prostaglandin E
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Disclosed are prostaglandin analogues having the structural formula, STR1 in which: T is selected from the group consisting of carboxyl, alkoxycarbonyl or cyano; M is selected from the group consisting of carbonyl, R-hydroxymethylene or S-hydroxymethylene; L is selected from the group consisting of methylene or methine, provided L is methine only if J is methine; J is selected from the group consisting of methylene, ethylene, R-hydroxymethylene, S-hydroxymethylene or methine, provided J is methine only if L is methine; W is selected from the group consisting of --CH2 --CH-- or trans --CH=C--; T1 and T2 are attached to adjacent carbon atoms; T1 is selected from the group consisting of hydrogen or phenyl, provided T1 is phenyl only if T2 is lower alkyl; T2 is selected from the group consisting of n-pentyl or lower alkyl, provided T2 is lower alkyl only if T1 is phenyl; Or T1 and T2 are joined together to form an alkylene group of 4 or 6 carbon atoms. Also disclosed are methods for preparing such prostaglandin analogues.
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