1-Amino-3-2-thiazoloxy!-2-propanol and substituted 1-amino derivatives thereof; 3-2-thiazoloxy!-1,2-epoxypropane 5-thiazol-2-oxymethylene!-oxazolidine and/or N-substituted and/or 2-substituted oxazolidine, derivatives thereof and methods of preparing such compounds. The above 1-amino-3-2-thiazoloxy!-2-propanol and derivatives exhibit . beta.-adrenergic stimulating cardiovascular activity and are useful for the treatment of abnormal heart conditions in mammals. The above 3-2-thiazoloxy!-1,2-epoxypropane and derivatives are useful as intermediates for the aforementioned cardiovascular agents. The 5-thiazol-2-oxymethylene!-oxazolidine and derivatives are intermediates for aforementioned cardiovascular agents. The 1-amino-3-2-thiazoloxy!-2-propanol and derivatives can be prepared by base or acid hydrolysis of the corresponding 5-thiazol-2-oxymethylene!-oxazolidine or derivatives; or by treatment of the corresponding 3-2-thiazoloxy!-2,3-epoxypropane or derivative with the desired amine or amino-derivative.
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(2008/06/13)
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