Convenient synthesis of 2-alkylamino-6-carboxy-5,7-diarylcyclopenteno[1,2- b]pyridines via direct acylamination with imidoyl chlorides
A robust synthetic method for 2-alkylamino-6-carboxy-5,7- diarylcyclopenteno[1,2-b]pyridines via acylamination at the alpha position of the functionalized pyridine system has been developed. The key step in this method was achieved by treatment of the corresponding pyridine N-oxides with 2.5 equiv of imidoyl chlorides in the presence of triethylamine, thus producing the desired 2-acylaminopyridines in good yields (74-96%).
Novel Pyrimidine Rearrangement Reaction. A New Synthesis of 4-Formylimidazoles
5-Aminopyrimidine gives, on mild heating with N-alkyl(aryl)imidoyl chlorides in the presence of phosphorus oxychloride, 4-formyl-1,2-dialkyl(aryl)imidazoles together with the N-(pyrimidin-5-yl)-N-alkyl(aryl)amidines.It was found that these amidines are th
Goenczi, C.,Swistun, Z.,Plas, H. C. van der
p. 608 - 610
(2007/10/02)
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