39887-75-7Relevant academic research and scientific papers
Convenient synthesis of 2-alkylamino-6-carboxy-5,7-diarylcyclopenteno[1,2- b]pyridines via direct acylamination with imidoyl chlorides
Takahashi, Hirobumi,Fukami, Takehiro,Kojima, Hisaki,Yamakawa, Takeru,Takahashi, Hiroyuki,Sakamoto, Toshihiro,Nishimura, Teruyuki,Nakamura, Masayuki,Yosizumi, Takashi,Niiyama, Kenji,Ohtake, Norikazu,Hayama, Takashi
, p. 3473 - 3481 (2005)
A robust synthetic method for 2-alkylamino-6-carboxy-5,7- diarylcyclopenteno[1,2-b]pyridines via acylamination at the alpha position of the functionalized pyridine system has been developed. The key step in this method was achieved by treatment of the corresponding pyridine N-oxides with 2.5 equiv of imidoyl chlorides in the presence of triethylamine, thus producing the desired 2-acylaminopyridines in good yields (74-96%).
Novel Pyrimidine Rearrangement Reaction. A New Synthesis of 4-Formylimidazoles
Goenczi, C.,Swistun, Z.,Plas, H. C. van der
, p. 608 - 610 (2007/10/02)
5-Aminopyrimidine gives, on mild heating with N-alkyl(aryl)imidoyl chlorides in the presence of phosphorus oxychloride, 4-formyl-1,2-dialkyl(aryl)imidazoles together with the N-(pyrimidin-5-yl)-N-alkyl(aryl)amidines.It was found that these amidines are th
