400081-87-0

Basic information

• Product Name: 2-[2-(4-fluorophenyl)-2-adamantyl]acetic acid
• Synonyms: 2-[2-(4-fluorophenyl)-2-adamantyl]acetic acid
• CAS NO: 400081-87-0
• Molecular Formula: C₁₈H₂₁FO₂
• Molecular Weight: 288.37
• Mol File: 400081-87-0.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-[2-(4-fluorophenyl)-2-adamantyl]acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[2-(4-fluorophenyl)-2-adamantyl]acetic acid(400081-87-0)
• EPA Substance Registry System: 2-[2-(4-fluorophenyl)-2-adamantyl]acetic acid(400081-87-0)

Safety Data

• Hazardous Substances Data: 400081-87-0(Hazardous Substances Data)

Upstream product

• 133709-18-9 2,2-dimethyl-5-(2-(4'-fluorophenyl)tricyclo[3.3.1.13,7]dec-2-yl)-1,3-dioxane-4,6-dione 
• 700-58-3 2-Adamantanone 
• 51757-47-2 2,2-Dimethyl-5-(tricyclo<3.3.1.1^3,7>decanylidene)-1,3-dioxane-4,6-dione 

Downstream Products

• 1009367-47-8 C₃₈H₃₅FNOP 

Relevant articles and documents

Design, synthesis, and SAR studies of novel polycyclic acids as potent and selective inhibitors of human 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1)

Starting from high throughput screening hit 2-adamantyl acetic acid 3, a series of polycyclic acids have been designed and synthesized as novel, potent, and selective inhibitors of human 11β-HSD-1. Structure-activity relationships of two different regions

CYCLIC 11-BETA HYDROXYSTEROID DEHYDROGENASE TYPE I INHIBITORS

Novel compounds are provided which are 11-beta-hydroxysteroid dehydrogenase type I inhibitors. 11-Beta-hydroxysteroid dehydrogenase type I inhibitors are useful in treating, preventing, or slowing the progression of diseases requiring 11-beta-hydroxysteroid dehydrogenase type I inhibitor therapy. These novel compounds have the structure (I) enantiomers, diastereomers, solvates, or salts thereof, wherein A, W, X and Z are defined herein.