133709-18-9Relevant academic research and scientific papers
Design, synthesis, and SAR studies of novel polycyclic acids as potent and selective inhibitors of human 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1)
Ye, Xiang-Yang,Chen, Stephanie Y.,Nayeem, Akbar,Golla, Rajasree,Seethala, Ramakrishna,Wang, Mengmeng,Harper, Timothy,Sleczka, Bogdan G.,Li, Yi-Xin,He, Bin,Kirby, Mark,Gordon, David A.,Robl, Jeffrey A.
supporting information; experimental part, p. 6699 - 6704 (2011/12/21)
Starting from high throughput screening hit 2-adamantyl acetic acid 3, a series of polycyclic acids have been designed and synthesized as novel, potent, and selective inhibitors of human 11β-HSD-1. Structure-activity relationships of two different regions
CYCLIC 11-BETA HYDROXYSTEROID DEHYDROGENASE TYPE I INHIBITORS
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Page/Page column 70, (2008/06/13)
Novel compounds are provided which are 11-beta-hydroxysteroid dehydrogenase type I inhibitors. 11-Beta-hydroxysteroid dehydrogenase type I inhibitors are useful in treating, preventing, or slowing the progression of diseases requiring 11-beta-hydroxysteroid dehydrogenase type I inhibitor therapy. These novel compounds have the structure (I) enantiomers, diastereomers, solvates, or salts thereof, wherein A, W, X and Z are defined herein.
