- 3,5-dimethyl-1H-pyrazole-1-carboxamidine hydrochloride preparation method
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The invention discloses a 3,5-dimethyl-1H-pyrazole-1-carboxamidine hydrochloride preparation method. According to the invention, the compound 3,5-dimethyl-1H-pyrazole-1-carboxamidine hydrochloride with a complex structure is synthesized with the raw materials of aminoguanidine carbonate, acetylacetone and the like. The product yield is high, and the product has good crystallization effect and high purity, such that high-purity standard sample or sample can be provided for subsequent chemical and biological experiments.
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Paragraph 0013; 0014; 0015
(2016/11/24)
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- 1H-Pyrazole-1-carboxamidines: New inhibitors of nitric oxide synthase
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1H-Pyrazole-1-carboxamidines were prepared as potential inhibitors of the three isozymes of nitric oxide synthase. All of the compounds were found to be competitive inhibitors of all three isoforms. The most selective compound prepared was 1H-pyrazole-N-(3-aminomethylanilino)-1-carboxamidine (14), which is 100-fold selective for nNOS over eNOS with a K(i) value of 2μM. (C) 2000 Elsevier Science Ltd.
- Lee, Younghee,Martasek, Pavel,Roman, Linda J,Silverman, Richard B
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p. 2771 - 2774
(2007/10/03)
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