cas 400720-77-6, (6-amino-pyridin-3-ylmethyl)-carbamic acid tert-butyl ester | Articles data ｜lookchem

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400720-77-6

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METTL3 INHIBITORY COMPOUNDS
The present invention relates to compounds of formula (I) that function as inhibitors of METTL3 (N6-adenosine-methyltransferase 70 kDa subunit) enzyme activity: X-Y-Z5 (I) wherein X, Y and Z are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, and autoimmune diseases, as well as other diseases or conditions in which METTL3 activity 10 is implicated.
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Paragraph 00983; 00987-00989

(2020/10/20)

NOVEL HETEROCYCLIC COMPOUNDS AS INHIBITORS OF VANIN-1 ENZYME
Compounds, pharmaceutically acceptable salts thereof, are disclosed wherein the compounds have the structure of Formula (I) as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.
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Page/Page column 108; 109

(2016/12/22)

AMINOPYRIDINE DERIVATIVES
The present invention provides compounds of formula (I): compositions comprising such compounds; the use of such compounds in therapy (such as asthma or COPD); and methods of treating patients with such compounds; wherein R1 - R11 ar
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Page/Page column 74

(2009/12/05)

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Chemical Properties

Boiling Point: 401.6±35.0 °C(Predicted)
Density: 1.138±0.06 g/cm3(Predicted)
Storage Temp.:2-8°C(protect from light)
PKA: 11.58±0.46(Predicted)
PSA: 81.46000
LogP: 1.82300

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