401-56-9

Basic information

• Product Name: ETHYL CHLOROFLUOROACETATE
• Synonyms: chlorofluoro-aceticaciethylester;ETHYL CHLOROFLUOROACETATE;CHLOROFLUOROACETIC ACID ETHYL ESTER;Ethylchlorofluoroacetate,98%;Ethyl chlorofluoroacetate 97%;Ethylchlorofluoroacetate97%;2-Chloro-2-fluoroacetic acid ethyl ester;Fluorochloroacetic acid ethyl ester
• CAS NO: 401-56-9
• Molecular Formula: C₄H₆ClFO₂
• Molecular Weight: 140.54
• EINECS: 206-930-5
• Product Categories: Carbonyl Compounds;Chemical Synthesis;Organic Building Blocks;Organic Fluorinated Building Blocks;Other Fluorinated Organic Building Blocks;Fluorinated Building Blocks;Fluorinating Reagents & Building Blocks for Fluorinated Biochemical Compounds;Synthetic Organic Chemistry;C2 to C5;Carbonyl Compounds;Esters;Alkyl Fluorinated Building Blocks;Building Blocks;C2 to C5
• Mol File: 401-56-9.mol

Chemical Properties

• Boiling Point: 133 °C(lit.)
• Flash Point: 125 °F
• Appearance: clear colorless liquid
• Density: 1.212 g/mL at 25 °C(lit.)
• Vapor Pressure: 10.4mmHg at 25°C
• Refractive Index: n20/D 1.396(lit.)
• BRN: 1748679
• CAS DataBase Reference: ETHYL CHLOROFLUOROACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL CHLOROFLUOROACETATE(401-56-9)
• EPA Substance Registry System: ETHYL CHLOROFLUOROACETATE(401-56-9)

Safety Data

• Hazard Codes: C,F,Xi
• Statements: 10-34
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 2920 8/PG 2
• WGK Germany: 3
• TSCA: Yes
• HazardClass: 3
• PackingGroup: III
• Hazardous Substances Data: 401-56-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
ETHYL CHLOROFLUOROCETATE is used as a chemical intermediate for the synthesis of chlorofluoroacetamide, which has potential applications in the development of pharmaceuticals.
Used in Chemical Synthesis:
ETHYL CHLOROFLUOROCETATE is used as a chemical intermediate for the synthesis of ethyl α-fluoro silyl enol ether, which can be utilized in various chemical reactions and processes.
Used in Specialty Chemicals:
ETHYL CHLOROFLUOROCETATE is used as a chemical intermediate for the production of chlorofluoroacetyl chloride, which is an important compound in the manufacture of specialty chemicals and materials.

InChI:InChI=1/C4H6ClFO2/c1-2-8-4(7)3(5)6/h3H,2H2,1H3/t3-/m0/s1

Upstream product

• 562-85-6 chloro-fluoro-orthoacetic acid triethyl ester 
• 64-17-5 ethanol 
• 359-34-2 chlorofluoroacetyl fluoride 
• 359-32-0 chlorofluoroacetyl chloride 
• 310-71-4 ethoxyflurane 
• 459-72-3 ethyl 2-fluoroacetate 
• 623-73-4 diazoacetic acid ethyl ester 

Downstream Products

• 730-71-2 2-chloro-1,1-bis-(4-chloro-phenyl)-2-fluoro-ethanol 
• 2356-16-3 ethyl(diethylphosphono)(fluoro)acetate 
• 129600-91-5 ethyl 2-(p-chlorophenylthio)-2-fluoroacetate 
• 39547-75-6 [4-(Ethoxycarbonyl-fluoro-methanesulfonyl)-benzenesulfonyl]-fluoro-acetic acid ethyl ester 
• 20808-13-3 ethyl 2-fluoro-2-(phenylsulfonyl)acetate 
• 39547-73-4 (4-Chloro-benzenesulfonyl)-fluoro-acetic acid ethyl ester 
• 39547-74-5 Fluoro-(4-nitro-benzenesulfonyl)-acetic acid ethyl ester 
• 216776-67-9 (5-Cyano-6-methyl-2-phenyl-pyrimidin-4-ylsulfanyl)-fluoro-acetic acid ethyl ester 
• 142753-36-4 α-fluoro-α-(phenylselanyl)acetic acid ethyl ester 
• 925693-54-5 2-chloro-2-fluoro-1-(4-methoxyphenyl) ethanone 
• 56773-32-1 4-(1'-fluoro-1'-carbethoxy-methyl mercapto)-phenol 
• 70395-35-6 sodium chlorofluoroacetate 
• 447-15-4 α-chloro-α-fluoroacetophenone 
• 321-76-6 2-chloro-2-fluoro-1-phenylethanol 

Relevant articles and documents

TRANSFORMATION D'OXYDES D'ALKYLES ET DE POLYFLUOROALKYLES PAR LES ACIDES DE LEWIS. INFLUENCE DES RADICAUX ALKYLES.

The generation of perfluoroalkanoyl fluorides from perfluoroalkyl ethers by Lewis acids RHOCF2RF -> FRH + RFCOF depends mainly upon the nature of the alkyl RH radical.It is necessary to use RH groups with donor character and also electrophilic groups present on the radicals can facilitate the breaking of the RH-O bond.As examples, ethers with Me3SiCH2CH2 or CH2=CH-CH2 groups allowed reactions to occur readily at room temperature or below using common Lewis acids such as ZnCl2, BF3-Et2O, AlCl3.

REACTION OF ALKYL 2-CHLORO-1,1,2-TRIFLUOROETHYL ETHERS WITH LEWIS ACIDS

Ethyl 2-chloro-1,1,2-trifluoroethyl ether heated with boron trifluoride etherate gave ethyl fluoride and chlorofluoroacetyl fluoride.When heated with aluminium chloride, it afforded a mixture of ethyl fluoride, ethyl chloride, chlorofluoroacetyl fluoride, and chlorofluoroacetyl chloride.Treatment of the acyl halides with ethanol yielded ethyl chlorofluoroacetate.Butyl and octyl 2-chloro-1,1,2-trifluoroethyl ethers gave directly butyl and octyl chlorofluoroacetates, respectively, under similar conditions.