- Technology for synthesizing 5-acetylsalicylamide
-
The invention discloses a technology for synthesizing 5-acetylsalicylamide. Methyl salicylate, methyl alcohol, acetylchloride, a self-made modified nano-scale solid acid catalyst and the like are subjected to recrystallization, magnetic stirring, acid treatment and other operation means to prepare the 5-acetylsalicylamide.
- -
-
Paragraph 0009-0034; 0036
(2019/08/20)
-
- 5 - acetyl salicylic amide synthesis method
-
The invention discloses a synthetic method for 5-acetylsalicylamide. The method comprises the following steps: putting anhydrous aluminum chloride and sodium chloride into a container, and performing heating and stirring until both anhydrous aluminum chloride and sodium chloride are fused to obtain low-melting-point NaCl-AlCl3 mixed fused salt; adding salicylamide into the low-melting-point NaCl-AlCl3 mixed fused salt, and stirring until salicylamide is fused; dropwise adding an acylation reagent, and after finishing the dropwise-adding process, producing a heat preservation reaction; immediately and slowly adding acid liquor into an obtained reaction product, and after finishing the process of adding the acid liquor, continuously stirring at the room temperature until no new solids are generated; filtering obtained turbid liquid to obtain a filter cake, and performing washing and drying on the filter cake to obtain a crude product of 5-acetylsalicylamide; purifying the crude product to obtain 5-acetylsalicylamide. The synthetic method for 5-acetylsalicylamide has the advantages of high yield, simple post-treatment, elimination of organic solvents and the like.
- -
-
Paragraph 0039; 0040; 0041; 0042; 0043-0057; 0068-0075
(2017/07/04)
-
- New heterocyclic chalcones. Part 6. Synthesis and cytotoxic activities of 5- or 6-(3-aryl- 2-propenoyl)-2(3H)-benzoxazolones
-
A number of chalcones bearing an oxazole cycle were synthesized by Claisen-Schmidt condensation of 5-acetyl-2(3 H )-benzoxazolone or 6-acetyl-2(3 H )-benzoxazolone and the appropriate aldehydes. The chalcones were evaluated for cytotoxic activity against several tumor cell lines - BV-173 (human B cell precursor leukemia), MCF-7 and MDA-MB-231 (human breast adenocarcinoma) using the MTT-dye reduction assay. The tested compounds exhibit concentration- dependent cytotoxic effects at micromolar concentrations. Exposure of the BV-173 tumor cell line to compound 3f results in strong monoand oligonucleosomal fragmentation of genomic DNA, as evidenced by a 'cell death detection' ELISA kit, which unambiguously indicates that the induction of apoptosis is implicated in the cytotoxic mode of action of the tested compound.
- Ivanova, Yordanka B.,Momekov, Georgi T.,Petrov, Ognyan I.
-
-
- 2-aminopyridine derivatives and combinatorial libraries thereof
-
The present invention relates to novel 2-aminopyridine derivative compounds of the following formula: wherein R1to R5have the meanings provided herein. The invention further relates to combinatorial libraries containing two or more such compounds, as well as methods of preparing 2-aminopyridine derivative compounds.
- -
-
-
