40187-51-7Relevant articles and documents
Technology for synthesizing 5-acetylsalicylamide
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Paragraph 0009-0034; 0036, (2019/08/20)
The invention discloses a technology for synthesizing 5-acetylsalicylamide. Methyl salicylate, methyl alcohol, acetylchloride, a self-made modified nano-scale solid acid catalyst and the like are subjected to recrystallization, magnetic stirring, acid treatment and other operation means to prepare the 5-acetylsalicylamide.
New heterocyclic chalcones. Part 6. Synthesis and cytotoxic activities of 5- or 6-(3-aryl- 2-propenoyl)-2(3H)-benzoxazolones
Ivanova, Yordanka B.,Momekov, Georgi T.,Petrov, Ognyan I.
, p. 23 - 28 (2013/05/22)
A number of chalcones bearing an oxazole cycle were synthesized by Claisen-Schmidt condensation of 5-acetyl-2(3 H )-benzoxazolone or 6-acetyl-2(3 H )-benzoxazolone and the appropriate aldehydes. The chalcones were evaluated for cytotoxic activity against several tumor cell lines - BV-173 (human B cell precursor leukemia), MCF-7 and MDA-MB-231 (human breast adenocarcinoma) using the MTT-dye reduction assay. The tested compounds exhibit concentration- dependent cytotoxic effects at micromolar concentrations. Exposure of the BV-173 tumor cell line to compound 3f results in strong monoand oligonucleosomal fragmentation of genomic DNA, as evidenced by a 'cell death detection' ELISA kit, which unambiguously indicates that the induction of apoptosis is implicated in the cytotoxic mode of action of the tested compound.
COMPOUNDS, COMPOSITIONS AND METHODS FOR INHIBITING THE BINDING OF PROTEINS CONTAINING AN SH2 DOMAIN TO COGNATE PHOSPHORYLATED PROTEINS
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, (2008/06/13)
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