- Heterocyclic lead(II) thioureato complexes as single-source precursors for the aerosol assisted chemical vapour deposition of PbS thin films
-
The lead N’-benzoylthioureato complexes of N-morpholine (1) and N-pyrrolidine (2) were synthesized and characterized by elemental analysis, Fourier Transform Infra-Red (FT-IR) spectroscopy, proton nuclear magnetic resonance (1H nmr) and thermogravimetric analyses (TGA). The X-ray single crystal structure of complex (1) was determined. The compounds were both used as single source precursors to deposit PbS films on glass substrates at 350, 400 and 450 °C using aerosol assisted chemical vapour deposition (AACVD) The surface morphology of PbS films were determined by scanning electron microscopy (SEM), the crystalline phases established by powder X-ray diffraction (p-XRD) analyses and composition by energy dispersive X-ray spectroscopy (EDX). The particle sizes were found to range between 82 and 85 nm from complex (1) and 70–105 nm for (2) The PbS films were studied by Near Infra-red (NIR) UV–Vis spectroscopy, band gap ranging from 1.46 to 1.55 eV were observed.
- Ketchemen, Kevin I.Y.,Mlowe, Sixberth,Nyamen, Linda D.,Aboud, Ahmed A.,Akerman, Matthew P.,Ndifon, Peter T.,O'Brien, Paul,Revaprasadu, Neerish
-
-
Read Online
- Synthesis, characterization and biological applications of bismuth(III) complexes with aroylthiourea ligands
-
This work describes the synthesis, structural characterization and biological applications of three new bismuth(III) complexes with aroylthiourea-based ligands: [Bi(La)3(HLa)] (1), [Bi2(Lb)4(μ-Lb)2]?2(C3H6O) (2), and [Bi6(μ-Lc)6(μ3-NO3)2(μ6-NO3)](NO3)3?4H2O (3), where HLa = N-benzoyl(N′,N′-diethylthiourea), HLb = N-benzoyl(morpholinylthiourea), and H2Lc = N2,N6-bis(diethylcarbamothioyl)pyridine-2,6-dicarboxamide. The ligands HLa and HLb were considered as monopodal, while H2Lc as bipodal. All compounds were characterized by melting point determination, Fourier-transform infrared spectroscopy (FTIR), proton proton and carbon-13 nuclear magnetic resonance spectroscopy (NMR), mass spectrometry (MS), elemental analysis (EA) and single-crystal X-ray diffraction (SC-XRD). Structural analysis showed that compound 1 was a mononuclear heptacoordinate complex, while compound 2 presented a dinuclear structure and compound 3 was built up by a hexanuclear framework. The proligands, the new complexes, and Bi(NO3)3?5H2O had their antibacterial activities evaluated against E. coli (ATCC 25922), S. aureus (ATCC 25923), and P. aeruginosa (ATCC 27853). The in vitro disk-diffusion (DD) method showed the ability of compound 2 to inhibit two types of bacteria (P. aeruginosa and S. aureus). In the results of minimum inhibitory concentration (MIC), all complexes showed significant activity against the tested microorganisms except for compound 1. The inorganic salt used for comparison showed antibacterial activity only against P. aeruginosa and the ligands showed no apparent activity. Compound 2 presented the best antibacterial activity among the tested substances, and its performance was remarkable even when compared to other similar compounds found in the literature, attesting the importance of targeting bismuth(III) aroylthioureas for further research on new drugs development.
- Burrow, Robert Alan,Chuy, Gabriela Pereira,Lang, Ernesto Schulz,Vizzotto, Bruno Stefanello,de Oliveira, Marcielli Indiara,dos Santos, Sailer Santos
-
-
- Synthesis and exploration of 2-morpholino-4-phenylthiazol-5-yl acrylamide derivatives for their effects against carbonic anhydrase I, II, IX and XII isoforms as a non-sulfonamide class of inhibitors
-
Novel series of 2-morpholino-4-phenylthiazol-5-yl acrylamide derivatives (8a–s) have been synthesized and explored as a non-sulfonamide class of carbonic anhydrase (CA, EC 4.2.1.1) inhibitors. The newly synthesized molecules were evaluated for their CA in
- Swain, Baijayantimala,Singh Digwal, Chander,Angeli, Andrea,Alvala, Mallika,Singh, Priti,Supuran, Claudiu T.,Arifuddin, Mohammed
-
-
- Design, synthesis and identification of novel substituted 2-amino thiazole analogues as potential anti-inflammatory agents targeting 5-lipoxygenase
-
Human 5-Lipoxygenase (5-LOX) is a key enzyme targeted for asthma and inflammation. Zileuton, the only drug against 5-LOX, was withdrawn from the market due to several problems. In the present study, the performance of rationally designed conjugates of thi
- Sinha, Shweta,Doble, Mukesh,Manju
-
-
- Pyrrole-thiazole based push-pull chromophores: An experimental and theoretical approach to structural, spectroscopic and NLO properties of the novel styryl dyes
-
Novel push-pull fluorophores constituted by two donors (substituted pyrrole and morpholine) linked to acceptor through thiazole electron spacer have been synthesized. The fluorophores are investigated for linear and non-linear optical properties by UV-VIS absorption and fluorescence spectroscopies, and by means of TD-DFT (B3LYP/6-31G(d)) method, with the aim of elucidating the ability of the morpholine/pyrrole-donor-thiazole-spacer based D-π-A fluorophores as organic NLO materials. The bond length alternation and generalized Mulliken-Hush (GMH) analysis is performed to understand the involvement of the donor in effective transfer of the charge to acceptor. Values of first-order hyperpolarizabilities (βCT or β0), obtained by the solvatochromic method (Lippert Mataga model), and the transition dipole moments (μeg) used to characterize and evaluate the non-linear optical performances of the D-π-A fluorophores in various microenvironments. The D-π-A fluorophores possess good values of βCT or β0 in different organic solvents and hold high thermal stabilities therefore can be used as potential organic NLO materials.
- Thorat, Kishor G.,Sekar, Nagaiyan
-
-
- Imidazo[1,2-a]pyridines linked with thiazoles/thiophene motif through keto spacer as potential cytotoxic agents and NF-κB inhibitors
-
A series of new imidazo[1,2-a]pyridine linked with thiazole/thiophene motif through a keto spacer were synthesized and tested for their cytotoxic potential against three human cancer cell lines including A549, HeLa and U87-MG using MTT assay. Compounds A2
- Vasu, Kamala K.,Digwal, Chander Singh,Pandya, Amit N.,Pandya, Dhaivat H.,Sharma, Jayesh A.,Patel, Sneha,Agarwal, Milee
-
p. 5463 - 5466
(2017/11/17)
-
- Resonance induced proton transfer leading to NIR emission in coumarin thiazole hybrid dyes: Synthesis and DFT insights
-
Two novel coumarin thiazole hybrid dyes (E)-2-(3-(2-(4-(4-hydroxy-2-oxo-2H-chromen-3-yl)-2-morpholinothiazol-5-yl)vinyl)-5,5-dimethylcyclohex-2-en-1-ylidene)malononitrile (CSI) and (E)-2-(3-(2-(4-(4-methoxy-2-oxo-2H-chromen-3-yl)-2-morpholinothiazol-5-yl)vinyl)-5,5-dimethylcyclohex-2-en-1-ylidene)malononitrile (MeOCSI) were synthesized. CSI exhibits near infrared emission with very large Stokes shift. The dye CSI shows resonance induced excited state intramolecular proton transfer (RI-ESIPT). DFT and TD-DFT calculations clearly support and define the finding.
- Shreykar, Milind R.,Sekar, Nagaiyan
-
supporting information
p. 4174 - 4177
(2016/08/24)
-
- ACCELERATORS FOR CURABLE COMPOSITIONS
-
Benzoylthiourea or benzoylthiourethane derivatives as cure accelerators for curable compositions are provided.
- -
-
-
- ACCELERATORS FOR TWO PART CURABLE COMPOSITIONS
-
Benzoylthiourea or benzoylthiourethane derivatives as cure accelerators for two part curable compositions are provided.
- -
-
-
- Crystal structures and antifungal activities of fluorine-containing thioureido complexes with nickel(II)
-
Ni(II) complexes with N-2-fluorobenzoylpiperidine-1-carbothioimidate (L2-), N-4-fluorobenzoylpiperidine-1-carbothioimidate (L3-), N-2- fluorobenzoylmorpholine- 1-carbothioimidate (L5-) and N-4- fluorobenzoylmorpholine-1-carbothioimidate (L6-) have been synthesized and characterized by elemental analysis, FTIR and 1H-NMR. The crystal structures of three ligands (HL2, HL3 and HL6) and the corresponding Ni(II) complexes ([Ni(L2)2], [Ni(L3)2] and [Ni(L6)2]) have been determined by X-ray diffraction. The antifungal activities of the Ni(II) complexes together and the corresponding ligands against the fungi Botrytis cinerea, Trichoderma spp., Myrothecium and Verticillium spp. have been investigated. The experimental results showed that the ligands and their complexes have antifungal abilities. When the fluorine was substituted on the para-benzoyl moiety, the antifungal activity of the ligands was obviously increased. Moreover, the ligands were stronger than their complexes in inhibiting fungal activities. The antifungal ability of HL6 is especially strong, and similar to that of the commercial fungicide fluconazole.
- Li, Chun,Yang, Wen,Liu, Huanhuan,Li, Mengying,Zhou, Weiqun,Xie, Juan
-
p. 15737 - 15749
(2014/01/17)
-
- Synthesis and characterization of novel yellow azo dyes from 2-morpholin-4-yl-1,3-thiazol-4(5H)-one and study of their azo-hydrazone tautomerism
-
Novel yellow azo dyes were synthesized by diazotization of aromatic amines followed by coupling with 2-morpholin-4-yl-1,3-thiazol-4(5H)-one and fully characterized. The geometries of the synthesized dyes for azo and hydrazone tautomeric forms were optimized using B3LYP, CAM-B3LYP and M06 functional and 6-31G(d) and 6-311++G (d,p) basis sets, also their electronic excitation properties were evaluated using density functional theory. The optimized geometries reveal that the hydrazone for is more stable than the azo form. Photophysical properties of the synthesized dyes were evaluated by UV-Visible spectroscopy and compared with computed vertical excitation obtained from TDDFT. The results clearly illustrate existence of dye 8a, 8b and 8c in hydrazone tautomeric form, while 8d exist in both azo as well as hydrazone form. Thermal stabilities were estimated by using thermo gravimetric analysis, and results revels that the synthesized dyes have good thermal stability.
- Umape, Prashant G.,Patil, Vikas S.,Padalkar, Vikas S.,Phatangare, Kiran R.,Gupta, Vinod D.,Thate, Abhinav B.,Sekar, Nagaiyan
-
p. 291 - 298
(2013/10/21)
-
- Efficient one-pot synthesis of alkyl 2-(dialkylamino)-4-phenylthiazole-5- carboxylates and single-crystal x-ray structure of methyl 2-(diisopropylamino)- 4-phenylthiazole-5-carboxylate
-
The reaction between secondary amines, benzoyl isothiocyanate, and dialkyl acetylenedicarboxylates (=dialkyl but-2-ynedioates) in the presence of silica gel (SiO2) led to alkyl 2-(dialkylamino)-4-phenylthiazole-5- carboxylates in fairly high yi
- Souldozi, Ali,Ramazani, Ali,Dadrass, Ali Reza,Slepokura, Katarzyna,Lis, Tadeusz
-
experimental part
p. 339 - 348
(2012/04/10)
-
- Facile synthesis of 3-aryl/alkylamino 5-aryl/alkyl 1,2,4-oxadiazoles from acylthiourea
-
Facile and selective synthesis of 3-aryl/alkylamino 5-aryl/alkyl 1,2,4-oxadiazoles starting from N-acylthioureas has been demonstrated. The regio-selectivity is achieved by simply selecting an appropriate base used for the generation of hydroxyl amine fro
- Chennakrishnareddy, Gundala,Debasis, Hazra,Jayan, Rapai,Manjunatha, Sulur G.
-
p. 6170 - 6173
(2011/11/30)
-
- A rapid, four-component synthesis of functionalized thiazoles
-
An efficient synthesis of 2-(dialkylamino)-4-phenyl)-1,3-thiazol-5-yl) (phenyl)methanone using acid chlorides, secondary amines, 2-bromoacethophenone and ammonium thiocyanate is described.
- Sabbaghan, Maryam,Alidoust, Mostafa,Hossaini, Zinatossadat
-
p. 824 - 828
(2012/04/23)
-
- One-pot synthesis of functionalized thioureas by reaction of benzoyl isothiocyanates, secondary amines, and alkyl propiolates
-
An efficient one-pot synthesis of functionalized thioureas is described via three-component reaction of benzoyl isothiocyanates, secondary amines, and alkyl propiolates in the presence of triphenylphosphine (20∈mol%).
- Yavari, Issa,Sayyed-Alangi, S. Zahra,Sabbaghan, Maryam,Hajinasiri, Rahimeh,Iravani, Nasir
-
experimental part
p. 1025 - 1028
(2009/11/30)
-
- Antimicrobial activity and structural study of disubstituted Thiourea Derivatives
-
The antimicrobial activity of six N-phenyl- and fourteen N-benzoylthiourea derivatives were evaluated from their Minimal Inhibitory Concentration (MIC) values using the microdilution procedure against ten microorganisms. Most of the compounds exhibited selective activity against fungi and Gram-positive bacteria, which were very effectively inhibited by some of the tested thioureas. Additionally, SAR considerations and four novel X-ray diffraction structures of N-benzoylthioureas are included. Springer-Verlag 2007.
- Cunha, Silvio,MacEdo Jr., Fernando C.,Costa, Giselle A. N.,Rodrigues Jr., Manoel T.,Verde, Rosival B. V.,De Souza Neta, Lourdes C.,Vencato, Ivo,Lariucci, Carlito,Sa, Fernando P.
-
p. 511 - 516
(2008/02/03)
-
- Synthesis of mono- and N,N-disubstituted thioureas and N-acylthioureas
-
1-Benzotriazole-1-carbothioamide (2), prepared from 1-cyanobenzotriazole (1) and hydrogen sulfide, reacts with amines to give thioureas 3a-e. Reactions of (benzotriazol-1-yl)carboximidamides 4a-d,f-j and acyl- 5a-f,i-k or arylaminocarbonyl- 5g,h (benzotri
- Katritzky, Alan R.,Kirichenko, Nataliya,Rogovoy, Boris V.,Kister, Jeremy,Tao, Hui
-
p. 1799 - 1805
(2007/10/03)
-
- An efficient synthesis of 1,2,4-oxathiazoles from N-acylthiourea derivatives
-
l,2,4-Oxathiazoles have been synthesized from their precursors, the N-acylthioureas by oxidative cyclization reaction. Ring structure and the charge distribution above the ring have also been studied.
- Chan, Chung Woo,Ng, Chun Ming Dominic,Ho, Joyce,Tin, Kam Chung
-
p. 216 - 219
(2007/10/03)
-
- SYNTHESIS AND STUDY OF NEW N-BENZOYLTHIOUREA DERIVATIVES
-
A series of new derivatives of N-benzoylthiourea were synthesized and characterized, and the kinetics of their reactions with cumene hydroperoxide was studied.
- Mukmeneva, N. A.,Khabikher, V. Kh.,Cherkasova, O. A.,Cherezova, E. N.,Tuzova, N. G.
-
p. 925 - 927
(2007/10/02)
-
- Reactions of N-(N',N'-Dialkyl(aryl)amino-thiocarbonyl)benzimidoylchlorides with Potassium Thiocyanate
-
The treatment of the title compound N-(amino-thiocarbonyl)-benzimidoylchloride 1 with potassium thiocyanate leads in dependence on the solvents (methanol, acetic acid, acetone) either to the 1,3,5-thiadiazine-2-thione 2a-d or to the ring opened isothiocya
- Weber, G.,Hartung, J.,Beyer, L.
-
p. 241 - 247
(2007/10/02)
-
- N'-Substituted N-Acyl- and N-Imidoyl-thioureas: Preparation and Conversion of N',N'-Disubstituted Compounds into 2-(N,N-Disubstituted Amino)thiazol-5-yl Ketones
-
Known methods were developed to give convenient general procedures for preparing N-acyl-N'-mono- and -N',N'-disubstituted thioureas from acid chlorides, and related N-imidoyl thioureas from imidoyl chlorides.In the products from three acid chlorides and ammonium thiocyanate the acyl isothiocyanates did not appear to be accompained by the isomeric thiocyanates.Treatment of N-(anilino)benzylidene-N',N'-disubstituted thioures with chloroacetone in the presence of triethylamine leads to 5-acetyl-4-phenyl-2-(N,N-disubstituted amino)thiazoles.In contrast, the corresponding N-benzoyl thioureas form only small amounts of these compounds; the main products are the 5-benzoyl-4-methyl isomers, and this unexpected outcome requires a revision of the literature.It is thought that formation of the 5-benzoyl-4-methylthiazoles involves N-C(4) fission of a cyclic intermediate to give an open-chain intermediate in which nucleophilic attack can occur at either the acetyl or the benzoyl group.One of the latter intermediates was generated directly from 2-acetyl-2-bromoacetophenone and N-methyl-N-phenylthiourea, and found to give the 5-benzoyl-4-methyl- and 5-acetyl-4-phenyl-thiazoles as the major and minor products, respectively.
- Brindley, Jocelyn C.,Caldwell, Jennifer M.,Meakins, G. Denis,Plackett, Simon J.,Price, Susan J.
-
p. 1153 - 1158
(2007/10/02)
-
- REACTIONS OF CARBONYL ISOTHIOCYANATES WITH CYCLIC ENAMINES
-
Reaction of carbonyl isothiocyanates with cyclic enamines were investigated and the IR, UV and electron impact mass spectra of the synthesized products are discussed.
- Uher, Michal,Foltin, Jozef,Floch, Lubomir
-
p. 2696 - 2702
(2007/10/02)
-