40398-30-9

Upstream product

• 110-91-8 morpholine 
• 1147550-11-5 ammonium thiocyanate 
• 98-88-4 benzoyl chloride 
• 936-52-7 1-(N-morpholino)cyclopent-1-ene 
• 532-55-8 Benzoyl isothiocyanate 
• 540-72-7 sodium thiocyanide 
• 333-20-0 potassium thioacyanate 
• 65-85-0 benzoic acid 
• 82655-60-5 N-(Morpholino-thiocarbonyl)benzimidchlorid 
• 670-80-4 4-cyclohexen-1-ylmorpholine 

Downstream Products

• 139564-83-3 (2E)-3-(2-Morpholino-4-phenyl-5-thiazolyl)acrylonitril 
• 108131-29-9 C₂₂H₁₈N₄O₄S 
• 108131-30-2 C₂₃H₂₀N₄O₄S 
• 108107-37-5 C₂₂H₁₇ClN₄O₄S 
• 108107-38-6 C₂₃H₂₀N₄O₅S 
• 82655-60-5 [(morpholinyl)(thiocarbonyl)]benzimidoyl chloride 
• 3414-94-6 5-phenyl-1,2,4-triazole-3-thiol 
• 114171-36-7 (4-Chloro-phenyl)-(2-morpholin-4-yl-4-phenyl-thiazol-5-yl)-methanone 
• 39696-48-5 1-Methyl-3-phenyl-1,2,4-triazoline-5-thione 
• 209049-88-7 5-chloroacetyl-2-morpholino-4-phenylthiazole 
• 862582-71-6 bis[N-(1-morpholinylthiocarbonyl)benzamidato]mercury(II) 
• 1173241-55-8 Re(phenylimino)Br₂(triphenylphosphine)(Morphbtu) 
• 1130656-01-7 (Z)-methyl 3-[benzoyl(morpholin-4-ylcarbothioyl)amino]-2-propenoate 
• 107111-48-8 4-(3-phenyl-1,2,4-oxadiazol-5-yl)morpholine 

Relevant academic research and scientific papers

Heterocyclic lead(II) thioureato complexes as single-source precursors for the aerosol assisted chemical vapour deposition of PbS thin films

The lead N’-benzoylthioureato complexes of N-morpholine (1) and N-pyrrolidine (2) were synthesized and characterized by elemental analysis, Fourier Transform Infra-Red (FT-IR) spectroscopy, proton nuclear magnetic resonance (1H nmr) and thermogravimetric analyses (TGA). The X-ray single crystal structure of complex (1) was determined. The compounds were both used as single source precursors to deposit PbS films on glass substrates at 350, 400 and 450 °C using aerosol assisted chemical vapour deposition (AACVD) The surface morphology of PbS films were determined by scanning electron microscopy (SEM), the crystalline phases established by powder X-ray diffraction (p-XRD) analyses and composition by energy dispersive X-ray spectroscopy (EDX). The particle sizes were found to range between 82 and 85 nm from complex (1) and 70–105 nm for (2) The PbS films were studied by Near Infra-red (NIR) UV–Vis spectroscopy, band gap ranging from 1.46 to 1.55 eV were observed.

Synthesis, characterization and biological applications of bismuth(III) complexes with aroylthiourea ligands

This work describes the synthesis, structural characterization and biological applications of three new bismuth(III) complexes with aroylthiourea-based ligands: [Bi(La)3(HLa)] (1), [Bi2(Lb)4(μ-Lb)2]?2(C3H6O) (2), and [Bi6(μ-Lc)6(μ3-NO3)2(μ6-NO3)](NO3)3?4H2O (3), where HLa = N-benzoyl(N′,N′-diethylthiourea), HLb = N-benzoyl(morpholinylthiourea), and H2Lc = N2,N6-bis(diethylcarbamothioyl)pyridine-2,6-dicarboxamide. The ligands HLa and HLb were considered as monopodal, while H2Lc as bipodal. All compounds were characterized by melting point determination, Fourier-transform infrared spectroscopy (FTIR), proton proton and carbon-13 nuclear magnetic resonance spectroscopy (NMR), mass spectrometry (MS), elemental analysis (EA) and single-crystal X-ray diffraction (SC-XRD). Structural analysis showed that compound 1 was a mononuclear heptacoordinate complex, while compound 2 presented a dinuclear structure and compound 3 was built up by a hexanuclear framework. The proligands, the new complexes, and Bi(NO3)3?5H2O had their antibacterial activities evaluated against E. coli (ATCC 25922), S. aureus (ATCC 25923), and P. aeruginosa (ATCC 27853). The in vitro disk-diffusion (DD) method showed the ability of compound 2 to inhibit two types of bacteria (P. aeruginosa and S. aureus). In the results of minimum inhibitory concentration (MIC), all complexes showed significant activity against the tested microorganisms except for compound 1. The inorganic salt used for comparison showed antibacterial activity only against P. aeruginosa and the ligands showed no apparent activity. Compound 2 presented the best antibacterial activity among the tested substances, and its performance was remarkable even when compared to other similar compounds found in the literature, attesting the importance of targeting bismuth(III) aroylthioureas for further research on new drugs development.

Synthesis and exploration of 2-morpholino-4-phenylthiazol-5-yl acrylamide derivatives for their effects against carbonic anhydrase I, II, IX and XII isoforms as a non-sulfonamide class of inhibitors

Novel series of 2-morpholino-4-phenylthiazol-5-yl acrylamide derivatives (8a–s) have been synthesized and explored as a non-sulfonamide class of carbonic anhydrase (CA, EC 4.2.1.1) inhibitors. The newly synthesized molecules were evaluated for their CA in

Design, synthesis and identification of novel substituted 2-amino thiazole analogues as potential anti-inflammatory agents targeting 5-lipoxygenase

Human 5-Lipoxygenase (5-LOX) is a key enzyme targeted for asthma and inflammation. Zileuton, the only drug against 5-LOX, was withdrawn from the market due to several problems. In the present study, the performance of rationally designed conjugates of thi

Imidazo[1,2-a]pyridines linked with thiazoles/thiophene motif through keto spacer as potential cytotoxic agents and NF-κB inhibitors

A series of new imidazo[1,2-a]pyridine linked with thiazole/thiophene motif through a keto spacer were synthesized and tested for their cytotoxic potential against three human cancer cell lines including A549, HeLa and U87-MG using MTT assay. Compounds A2

Pyrrole-thiazole based push-pull chromophores: An experimental and theoretical approach to structural, spectroscopic and NLO properties of the novel styryl dyes

Novel push-pull fluorophores constituted by two donors (substituted pyrrole and morpholine) linked to acceptor through thiazole electron spacer have been synthesized. The fluorophores are investigated for linear and non-linear optical properties by UV-VIS absorption and fluorescence spectroscopies, and by means of TD-DFT (B3LYP/6-31G(d)) method, with the aim of elucidating the ability of the morpholine/pyrrole-donor-thiazole-spacer based D-π-A fluorophores as organic NLO materials. The bond length alternation and generalized Mulliken-Hush (GMH) analysis is performed to understand the involvement of the donor in effective transfer of the charge to acceptor. Values of first-order hyperpolarizabilities (βCT or β0), obtained by the solvatochromic method (Lippert Mataga model), and the transition dipole moments (μeg) used to characterize and evaluate the non-linear optical performances of the D-π-A fluorophores in various microenvironments. The D-π-A fluorophores possess good values of βCT or β0 in different organic solvents and hold high thermal stabilities therefore can be used as potential organic NLO materials.

Resonance induced proton transfer leading to NIR emission in coumarin thiazole hybrid dyes: Synthesis and DFT insights

Two novel coumarin thiazole hybrid dyes (E)-2-(3-(2-(4-(4-hydroxy-2-oxo-2H-chromen-3-yl)-2-morpholinothiazol-5-yl)vinyl)-5,5-dimethylcyclohex-2-en-1-ylidene)malononitrile (CSI) and (E)-2-(3-(2-(4-(4-methoxy-2-oxo-2H-chromen-3-yl)-2-morpholinothiazol-5-yl)vinyl)-5,5-dimethylcyclohex-2-en-1-ylidene)malononitrile (MeOCSI) were synthesized. CSI exhibits near infrared emission with very large Stokes shift. The dye CSI shows resonance induced excited state intramolecular proton transfer (RI-ESIPT). DFT and TD-DFT calculations clearly support and define the finding.

ACCELERATORS FOR CURABLE COMPOSITIONS

Benzoylthiourea or benzoylthiourethane derivatives as cure accelerators for curable compositions are provided.

ACCELERATORS FOR TWO PART CURABLE COMPOSITIONS

Benzoylthiourea or benzoylthiourethane derivatives as cure accelerators for two part curable compositions are provided.

Synthesis and characterization of novel yellow azo dyes from 2-morpholin-4-yl-1,3-thiazol-4(5H)-one and study of their azo-hydrazone tautomerism

Novel yellow azo dyes were synthesized by diazotization of aromatic amines followed by coupling with 2-morpholin-4-yl-1,3-thiazol-4(5H)-one and fully characterized. The geometries of the synthesized dyes for azo and hydrazone tautomeric forms were optimized using B3LYP, CAM-B3LYP and M06 functional and 6-31G(d) and 6-311++G (d,p) basis sets, also their electronic excitation properties were evaluated using density functional theory. The optimized geometries reveal that the hydrazone for is more stable than the azo form. Photophysical properties of the synthesized dyes were evaluated by UV-Visible spectroscopy and compared with computed vertical excitation obtained from TDDFT. The results clearly illustrate existence of dye 8a, 8b and 8c in hydrazone tautomeric form, while 8d exist in both azo as well as hydrazone form. Thermal stabilities were estimated by using thermo gravimetric analysis, and results revels that the synthesized dyes have good thermal stability.