404-15-9

Basic information

• Product Name: 1-ACETOXY-4-FLUOROBENZENE
• Synonyms: ACETIC ACID 4-FLUOROPHENYL ESTER;P-FLUOROPHENYL ACETATE;fluoro-aceticaciphenylester;phenylfluoroacetate
• CAS NO: 404-15-9
• Molecular Formula: C₈H₇FO₂
• Molecular Weight: 154.14
• EINECS: 206-972-4
• Product Categories: Aromatic Halides (substituted)
• Mol File: 404-15-9.mol

Chemical Properties

• Boiling Point: 197 °C(lit.)
• Flash Point: 190 °F
• Appearance: /
• Density: 1.178 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.432mmHg at 25°C
• Refractive Index: n20/D 1.48(lit.)
• CAS DataBase Reference: 1-ACETOXY-4-FLUOROBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-ACETOXY-4-FLUOROBENZENE(404-15-9)
• EPA Substance Registry System: 1-ACETOXY-4-FLUOROBENZENE(404-15-9)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• WGK Germany: 3
• Hazardous Substances Data: 404-15-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1-Acetoxy-4-fluorobenzene is used as a chemical intermediate for the synthesis of pharmaceuticals, contributing to the development of new drugs and medications.
Used in Agrochemical Industry:
1-ACETOXY-4-FLUOROBENZENE is also utilized as an intermediate in the production of agrochemicals, aiding in the creation of pesticides and other agricultural chemicals to protect crops and enhance yields.
Used in Organic Compounds Synthesis:
1-Acetoxy-4-fluorobenzene serves as a key intermediate in the synthesis of a range of organic compounds, facilitating the development of various chemical products for different industries.
It is crucial to handle 1-Acetoxy-4-fluorobenzene with care due to its potential harmful effects if inhaled, ingested, or comes into contact with the skin.

InChI:InChI=1/C8H7FO2/c1-6(10)11-8-4-2-7(9)3-5-8/h2-5H,1H3

Upstream product

• 359-06-8 monofluoroacetyl chloride 
• 108-95-2 phenol 
• 450-95-3 2-fluoroacetophenone 

Relevant articles and documents

A new finding in selective Baeyer-Villiger oxidation of α-fluorinated ketones; a new and practical route for the synthesis of α-fluorinated esters

α-Fluorinated esters were effectively prepared by the Baeyer-Villiger oxidation of α-fluorinated ketones with m-chloroperbenzoic acid (m-CPBA) under mild conditions. The yield of the esters was influenced by the choice of solvent, base, and substituent on the aryl group of the ketones. 4-Methoxyphenyl substituted fluoroketones were oxidized almost quantitatively with m-CPBA within 10 min to 12 h at room temperature using 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) as a cosolvent with CH2Cl2 (1:1, v/v) and aqueous buffer (KH2PO4-NaOH, pH 7.6) as an additive base. The oxidation reaction rates of α-fluorinated ketones were higher than those of the corresponding non-fluorinated ketones. The fluorine atom at α-position of fluoromethyl aryl ketones enhanced the reactivity in the Baeyer-Villiger oxidation.