404-90-0

Basic information

• Product Name: 3-FLUORO-4-METHOXYPHENYLACETONITRILE
• Synonyms: 3-FLUORO-4-METHOXYBENZYL CYANIDE;3-FLUORO-4-METHOXYPHENYLACETONITRILE;3-Fluoro-4-methoxyphenylacetonitrile98%;2-(3-fluoro-4-methoxyphenyl)acetonitrile;2-(3-fluoro-4-methoxy-phenyl)acetonitrile;2-(3-fluoro-4-methoxy-phenyl)ethanenitrile;4-(Cyanomethyl)-2-fluoroanisole;Benzeneacetonitrile, 3-fluoro-4-Methoxy-
• CAS NO: 404-90-0
• Molecular Formula: C₉H₈FNO
• Molecular Weight: 165.16
• Product Categories: Fluorine series
• Mol File: 404-90-0.mol

Chemical Properties

• Melting Point: 46-48°C
• Boiling Point: 270.6 °C at 760 mmHg
• Flash Point: 117.5 °C
• Appearance: /
• Density: 1.148 g/cm³
• Vapor Pressure: 0.00676mmHg at 25°C
• Refractive Index: 1.501
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 3-FLUORO-4-METHOXYPHENYLACETONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-FLUORO-4-METHOXYPHENYLACETONITRILE(404-90-0)
• EPA Substance Registry System: 3-FLUORO-4-METHOXYPHENYLACETONITRILE(404-90-0)

Safety Data

• Hazard Codes: Xi
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39
• RIDADR: 3439
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 404-90-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3-Fluoro-4-methoxyphenylacetonitrile is used as a key intermediate in the synthesis of various pharmaceuticals. Its unique structure allows for the development of new drugs with improved therapeutic properties and reduced side effects.
Used in Agrochemical Industry:
In the agrochemical industry, 3-Fluoro-4-methoxyphenylacetonitrile serves as an essential building block for the production of agrochemicals, such as pesticides and herbicides. Its incorporation into these compounds can enhance their effectiveness in controlling pests and weeds, thereby increasing crop yields.
Used in Fine Chemicals Manufacturing:
3-Fluoro-4-methoxyphenylacetonitrile is utilized in the manufacture of fine chemicals, which are high-purity chemicals used in various applications, including the production of specialty materials, fragrances, and flavors. Its presence in these compounds contributes to their unique properties and performance.
Used in Research and Development:
3-Fluoro-4-methoxyphenylacetonitrile is an important compound in research and development, where it is employed to explore new chemical reactions, synthesis pathways, and potential applications. Its unique structure and reactivity make it a valuable tool for advancing scientific knowledge and discovering innovative solutions in the chemical industry.

InChI:InChI=1/C9H8FNO/c1-12-9-3-2-7(4-5-11)6-8(9)10/h2-3,6H,4H2,1H3

Upstream product

• 351-52-0 3-fluoro-4-methoxybenzyl chloride 
• 143-33-9 sodium cyanide 
• 102-86-3 tri-n-hexylamine 
• 331-61-3 3-fluoro-4-methoxybenzyl bromide 
• 351-54-2 3-fluoro-p-anisaldehyde 
• 38622-91-2 [(p-methylphenyl)sulfonylmethyl]isonitrile 
• 321-28-8 1-fluoro-2-methoxybenzene 

Downstream Products

• 3826-44-6 2-(3-fluoro-4-methoxy-phenyl)-3c-[2]furyl-acrylonitrile 
• 458-40-2 2-(3-fluoro-4-methoxyphenyl)ethan-1-amine 
• 458-09-3 (3-fluoro-4-hydroxyphenyl)acetic acid 
• 452-14-2 2-(4-fluoro-3-methoxyphenyl)acetic acid 
• 580-79-0 2-(3-fluoro-4-methoxy-phenyl)-3c-(4-fluoro-phenyl)-acrylonitrile 
• 612-85-1 3c-(2-chloro-phenyl)-2-(3-fluoro-4-methoxy-phenyl)-acrylonitrile 
• 580-78-9 2-(3-fluoro-4-methoxy-phenyl)-3c-phenyl-acrylonitrile 
• 346-90-7 3c-(3,4-dimethoxy-phenyl)-2-(3-fluoro-4-methoxy-phenyl)-acrylonitrile 
• 448-98-6 3c-(3,4-dichloro-phenyl)-2-(3-fluoro-4-methoxy-phenyl)-acrylonitrile 
• 580-80-3 2-(3-fluoro-4-methoxy-phenyl)-3c-(4-isopropyl-phenyl)-acrylonitrile 
• 127437-35-8 Cyano-(3-fluoro-4-methoxy-phenyl)-acetic acid ethyl ester 
• 1027841-19-5 (3,4-Diamino-phenyl)-(3-fluoro-4-methoxy-phenyl)-methanone 
• 1026593-27-0 (3-Amino-4-nitro-phenyl)-(3-fluoro-4-methoxy-phenyl)-methanone 
• 1025896-88-1 Propane-2-sulfonic acid [2-amino-5-(3-fluoro-4-methoxy-benzoyl)-phenyl]-amide 

Relevant articles and documents

Fluorine substituted methoxyphenylalkyl amides as potent melatonin receptor agonists?

A series of fluorine substituted methoxyphenylalkyl amides were prepared with different orientations of the fluorine and methoxy groups with respect to the alkylamide side chain and with alkyl sides of differing lengths (n = 1-3). β-Dimethyl and α-methyl

Compositions for Treatment of Cystic Fibrosis and Other Chronic Diseases

The present invention relates to pharmaceutical compositions comprising an inhibitor of epithelial sodium channel activity in combination with at least one ABC Transporter modulator compound of Formula A, Formula B, Formula C, or Formula D. The invention also relates to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis using the pharmaceutical combination compositions.

COMPOSITIONS FOR TREATMENT OF CYSTIC FIBROSIS AND OTHER CHRONIC DISEASES

The present invention relates to pharmaceutical compositions comprising an inhibitor of epithelial sodium channel activity in combination with at least one ABC Transporter modulator compound of Formula A, Formula B, Formula C, or Formula D. The invention also relates to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis using the pharmaceutical combination compositions.

Modulators of ATP-binding cassette transporters

Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.

Pyrazinone thrombin inhibitors

Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions having the following structure: for example:

USE OF QSAR IN DESIGN OF ANTIINFLAMMATORY FLUORINATED ARYLALKANOIC ACIDS

A series of 3-fluoro-4-alkoxyphenylalkanoic acids III was synthetized and their antiinflammatory activity and fibrinolytic capacity was evaluated.The suitable fluorinated derivative with better pharmacological profile than 3-chloro-4-benzyloxyphenylacetic acid (benzofenac) was selected.Experimental, biological activities of acids III were compared with those calculated by introducing the physico-chemical parameters into the formerly derived regression equations.Good coincidence was found out, as well as similarity of the regression equations derived for the originalseries of acids extended by the acids III.Lipophilicity of the acids under study was evaluated by partition thin-layer chromatography; the values of log P of benzyloxy derivatives IIIc-IIIf were lower than tabulated values - probably due to the intramolecular hydrophobic interactions of aromatic nuclei.

M-phenoxybenzyl and α-cyano-M-phenoxybenzyl esters of 2-haloalkyl (oxy-, thio-, sulfinyl-, or sulfonyl)phenylalkanoic acids

The invention is m-phenoxybenzyl esters of 2-haloalkyl(oxy-, thio-, sulfinyl-, or sulfonyl)phenylalkanoic acids which are useful insecticidal and acaricidal agents.

2-Haloalkyl(oxy-, thio-, sulfinyl-, or sulfonyl)-phenylalkanoic acids

The invention is 2-haloalkyl(oxy-, thio-, sulfinyl-, or sulfonyl)phenylalkanoic acids which are useful intermediates in the preparation of insecticides of m-phenoxybenzyl and α-cyano-m-phenoxybenzyl esters.