321-28-8Relevant articles and documents
Reaction of Acetyl Hypofluorite with Aromatic Mercury Compounds: a New Selective Fluorination Method
Visser, Gerard W. M.,Halteren, Bert W. v.,Herscheid, Jacobus D. M.,Brinkman, Gerard A.,Hoekstra, Arend
, p. 655 - 656 (1984)
Aromatic fluorine compounds are prepared in acetic acid from the corresponding mercury compounds and acetyl hypofluorite.
N,N′-Difluoro-1,4-diazoniabicyclo[2.2.2]octane Salts, Highly Reactive and Easy-to-Handle Electrophilic Fluorinating Agents
Umemoto, Teruo,Nagayoshi, Masayuki
, p. 2287 - 2295 (1996)
A series of N,N′-difluoro-1,4-diazoniabicyclo[2.2.2]octane salts were synthesized in a pure form by the fluorination of 1,4-diazabicyclo[2.2.2]octane with F2 diluted with N2 in the presence of a Bronsted acid in fluoro alcohol or acetonitrile or by fluorination followed by a treatment with a different Bronsted or Lewis acid. Their complete structural assignment was made based on spectral and elemental analyses of the isolated crystals. A great through-bond interaction between the two N-F's of the salt was observed on 19FNMR. An assessment was made of the usefulness of N,N′-difluoro-1,4-diazoniabicyclo[2.2.2]octane bis(triflate), bis(HSO2), bis(BF4), and bis(SbF6) salts for electrophilic fluorination; the bis-(BF4) salt was demonstrated to be widely applicable as a highly reactive and easy-to-handle fluorinating agent. Thus, the bis(BF4) salt readily fluorinated activated aromatics, active methylene compounds or their salts, substituted styrenes, and vinyl acetates under mild conditions. It was shown that one N-F of the salt was effective for fluorination and that the other N-F played a role to activate fluorination through the bonds. Thus, the reaction mechanism was discussed, and fluorination followed by an immediate intramolecular one-electron transfer was suggested.
Anand et al.
, p. 807 (1975)
DIRECT FLUORINATION OF PHENOL AND CRESOLS
Misaki, Susumu
, p. 159 - 172 (1981)
A study has been made of the reaction of phenol with elemental fluorine using a variety of solvents and reaction temperatures.Yields of o- and p-fluorophenol were obtained as high as 85percent.The isomer ratio changed drastically between phenol conversions of 10percent and 56percent.The o-isomer changed to unidentified polymeric substances at higher conversion, but it might also be assumed that interconversion of some isomers is occuring.The three cresols have also been succesfully fluorinated with elemental fluorine. p-Cresol gave some expected 2-fluoroderivative but also formed a fluorocyclohexadienyl ketone.
Photochemical (Hetero-)Arylation of Aryl Sulfonium Salts
Zhao, Yue,Yu, Congjun,Liang, Wenjing,Patureau, Frederic W.
supporting information, p. 6232 - 6236 (2021/08/23)
The construction of (hetero)biaryls, which are ubiquitous scaffolds among medical substances, functional materials, and agrochemicals, constitutes a key application of cross-coupling methods. However, these usually require multiple synthetic steps. Herein, we report a simple photoinduced and catalyst-free C-H/C-H (hetero)arylation cross-coupling through aryl thianthrenium salts, which are formed site-selectively by direct C-H functionalization. The key to this approach is the UV-light, which can disrupt the C-S bond to form thianthrene radical cations and aryl radicals.
List fluoro Radicamine compounds and their use and preparation method
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Paragraph 0082-0084, (2017/12/02)
The invention discloses a mono-fluorinated Radicamine compound which has a structure as shown in a formula (1), and further provides a preparation method for the mono-fluorinated Radicamine compound with the structure as shown in the formula (1) and an application of the mono-fluorinated Radicamine compound or the mono-fluorinated Radicamine compound prepared with the method to preparation of drugs for preventing and/or treating diabetes, drugs for preventing and/or treating Gaucher's diseases, drugs for preventing and/or treating tumors or antiviral drugs. The mono-fluorinated Radicamine compound provided by the invention is good in glycosidase inhibition activity.
