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3-(2-BROMO-4-FLUORO-PHENYL)-PROPAN-1-OL is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 404575-32-2 Structure
  • Basic information

    1. Product Name: 3-(2-BROMO-4-FLUORO-PHENYL)-PROPAN-1-OL
    2. Synonyms: 3-(2-BROMO-4-FLUORO-PHENYL)-PROPAN-1-OL
    3. CAS NO:404575-32-2
    4. Molecular Formula: C9H10BrFO
    5. Molecular Weight: 233.0775032
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 404575-32-2.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 295.772°C at 760 mmHg
    3. Flash Point: 132.678°C
    4. Appearance: /
    5. Density: 1.488g/cm3
    6. Vapor Pressure: 0.001mmHg at 25°C
    7. Refractive Index: 1.547
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. CAS DataBase Reference: 3-(2-BROMO-4-FLUORO-PHENYL)-PROPAN-1-OL(CAS DataBase Reference)
    11. NIST Chemistry Reference: 3-(2-BROMO-4-FLUORO-PHENYL)-PROPAN-1-OL(404575-32-2)
    12. EPA Substance Registry System: 3-(2-BROMO-4-FLUORO-PHENYL)-PROPAN-1-OL(404575-32-2)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 404575-32-2(Hazardous Substances Data)

404575-32-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 404575-32-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,0,4,5,7 and 5 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 404575-32:
(8*4)+(7*0)+(6*4)+(5*5)+(4*7)+(3*5)+(2*3)+(1*2)=132
132 % 10 = 2
So 404575-32-2 is a valid CAS Registry Number.
InChI:InChI=1/C9H10BrFO/c10-9-6-8(11)4-3-7(9)2-1-5-12/h3-4,6,12H,1-2,5H2

404575-32-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-(2-bromo-4-fluorophenyl)propan-1-ol

1.2 Other means of identification

Product number -
Other names Benzenepropanol,2-bromo-4-fluoro

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:404575-32-2 SDS

404575-32-2Relevant articles and documents

Highly Diastereoselective Synthesis of Medium-Sized Carbocycle-Fused Piperidines via Sequential Hydride Shift Triggered Double C(sp3)-H Bond Functionalization

Kataoka, Miyabi,Otawa, Yuna,Ido, Natsuki,Mori, Keiji

supporting information, p. 9334 - 9338 (2019/11/19)

Herein we report a diastereoselective synthesis of medium-sized carbocycle-fused piperidines via [1,n (n = 6, 7)]-[1,5]-sequential hydride shift triggered double C(sp3)-H bond functionalization. When cinnamylidene malonates having N,N-dibenzyl propylamine moiety were treated with 5 mol % of Yb(OTf)3, a [1,6]-[1,5]-sequential hydride shift/cyclization process proceeded to afford seven-membered carbocycle-fused piperidines with excellent diastereoselectivities. This sequential system was applicable to the synthesis of eight-membered carbocycle-fused piperidines by an unprecedented [1,7]-[1,5]-sequential hydride shift/cyclization process.

Construction of seven-and eight-membered carbocycles by Lewis acid catalyzed C(sp3)-H bond functionalization

Otawa, Yuna,Mori, Keiji

supporting information, p. 13856 - 13859 (2019/11/21)

We achieved a concise construction of seven-and eight-membered carbocycles via Lewis acid catalyzed C(sp3)-H bond functionalization. In these reactions, a quite rare [1,6 (or 7)]-hydride shift/cyclization process proceeded smoothly to afford seven-and eight-membered carbocycles with good chemical yields starting from substrates with high conformational freedom.

PROSTAGLANDIN E RECEPTOR ANTAGONISTS

-

Page/Page column 4, (2010/10/19)

The present invention provides prostaglandin receptor antagonist compounds represented by the general formula I, wherein A, R, R1 and R2 are as defined in the specification.

Prostaglandin EP4 antagonist

-

, (2008/06/13)

Disclosed herein are methods and compositions related to compound 1 or a pharmaceutically acceptable salt, or a prodrug thereof (all of which are referred to hereafter, collectively or individually, as “compound 1”), which is an antagonist of a prostaglandin EP4 receptor, or is a prostaglandin EP4 antagonist. Also disclosed is a method comprising administering a prostaglandin EP4 antagonist to a mammal suffering from, or at risk of developing, a disease or condition selected from the group consisting of cancer, immunological disorders, neurodegenerative disorders, ocular diseases, hepatic diseases, renal diseases, septicemia, fibromyalgia, dermatological disorders, and antipyrexia.

Prostaglandin D2 antagonist

-

, (2008/06/13)

Disclosed herein is compound 1 or a pharmaceutically acceptable salt, or a prodrug thereof. Compound 1 is useful for treating or preventing a variety of diseases or conditions. Results presented herein also demonstrate that Compound 1 is a prostaglandin D2 antagonist, and as such is useful in the treatment or prevention of prostaglandin D2 mediated conditions or diseases. A method comprising administering a prostaglandin D2 antagonist to a mammal suffering from a disease or condition selected from the group consisting of the gastrointestinal tract disorders or diseases, hyperalgesia, allodynia, abdominal cramping, glaucoma, ocular hypertension, and ocular hypotension is also disclosed herein. Pharmaceutical compositions and products comprising compound 1 are also disclosed.

Interheteroaryl 7-oxabicyclic [2.2.1]heptane oxazoles as prostaglandin F2α antagonists

-

, (2008/06/13)

The present invention provides novel compounds represented by the general formula I. wherein m, n, X, Y, Z, R, R1and R2are as defined in the specification or a pharmaceutically acceptable salt thereof. The novel compounds are PGF2αantagonists, useful in pharmaceutical compositions for treating PGF2α-mediated disease responses such as inflammatory reactions relating to rheumatoid arthritis and psoriasis, reproductive disorders, bronchoconstrictive disorders (asthma), excessive bone breakdown (osteoporosis), peptic ulcers, heart disease, platelet aggregation and thrombosis.

Interphenylene 7-oxabicyclic [2.2.1] heptane oxazoles as prostaglandin F2a antagonists

-

, (2008/06/13)

The present invention provides novel compounds represented by the general formula I. wherein m is an integer of from 1 to 3; n is 0 or an integer of from 1 to 4; R is selected from the group consisting of CO2H, CO2R6, CH2OH, CH2O R6 ?and CONR3R4; R1and R2are independently selected from the group consisting of H, R6, C1-C6alkenyl, C1-C6alkynyl, C3-C7cycloalkyl, C4-C12alkylcycloalkyl, C6-C10aryl, C7-C12alkyl aryl radicals and heteroatom-substituted derivatives thereof, wherein one or more of the hydrogen or carbon atoms in said radicals is replaced with a halogen, nitrogen or sulfur-containing radical; R3and R4are selected from the group consisting of H and R6; and X is selected from the group consisting of R6, hydroxy, N(R6)2, CON(R6)2, SR6, sulfoxy, sulfone, halogen, COOR6, NO2, CN and OR6, wherein R6is C1-C6alkyl, and pharmaceutically acceptable salts thereof. The novel compounds are PGF2αantagonists, useful in pharmaceutical compositions for treating PGF2α-mediated disease responses such as inflammatory reactions relating to rheumatoid arthritis and psoriasis, reproductive disorders, bronchoconstrictive disorders (asthma), excessive bone breakdown (osteoporosis), peptic ulcers, heart disease, platelet aggregation and thrombosis.

Interheteroaryl 7-oxabicyclic [2.2.1]heptane oxazoles as prostaglandin F2alpha antagonists

-

, (2008/06/13)

The present invention provides novel compounds represented by the general wherein m, n, X, Y, Z, R, R1 and R2 are as defined in the specification or a pharmaceutically acceptable salt thereof. The novel compounds are PGF2α antagonists, useful in pharmaceutical compositions for treating PGF2α-mediated disease responses such as inflammatory reactions relating to rheumatoid arthritis and psoriasis, reproductive disorders, bronchoconstrictive disorders (asthma), excessive bone breakdown (osteoporosis), peptic ulcers, heart disease, platelet aggregation and thrombosis.

Interheteroaryl 7-oxabicyclic [2.2.1]heptane oxazoles as prostaglandin F2α antagonists

-

, (2008/06/13)

The present invention provides novel compounds represented by the general formula I. wherein m is an integer of from 1 to 3; n is 0 or an integer of from 1 to 4; R is selected from the group consisting of CO2H, CO2R6, CH2OH, CH2O R6P(O)(OH)2, ?and CONR3R4; R1and R2are independently selected from the group consisting of H, R6, C1-C6alkenyl, C1-C6alkynyl, C3-C7cycloalkyl, C4-C12alkylcycloalkyl, C6-C10aryl, C7-C12alkyl aryl radicals and heteroatom-substituted derivatives thereof, wherein one or more of the hydrogen or carbon atoms in said radicals is replaced with a halogen, nitrogen or sulfur-containing radical; R3and R4are selected from the group consisting of H and R6; and X is selected from the group consisting of H, R6, hydroxy, N(R6)2, CON(R6)2, SR6, sulfoxy, sulfone, halogen, COOR6, NO2, CN and OR6, wherein R6is C1-C6alkyl; Y is O or S; Z is N or CH and pharmaceutically acceptable salts thereof. The novel compounds are PGF2αantagonists, useful in pharmaceutical compositions for treating PGF2α-mediated disease responses such as inflammatory reactions relating to rheumatoid arthritis and psoriasis, reproductive disorders, bronchoconstrictive disorders (asthma), excessive bone breakdown (osteoporosis), peptic ulcers, heart disease, platelet aggregation and thrombosis.

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