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6,7-difluoronaphthalene-1-carboxylic acid is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 405196-36-3 Structure
  • Basic information

    1. Product Name: 6,7-difluoronaphthalene-1-carboxylic acid
    2. Synonyms: 6,7-difluoronaphthalene-1-carboxylic acid
    3. CAS NO:405196-36-3
    4. Molecular Formula: C11H6F2O2
    5. Molecular Weight: 208.1609464
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 405196-36-3.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 6,7-difluoronaphthalene-1-carboxylic acid(CAS DataBase Reference)
    10. NIST Chemistry Reference: 6,7-difluoronaphthalene-1-carboxylic acid(405196-36-3)
    11. EPA Substance Registry System: 6,7-difluoronaphthalene-1-carboxylic acid(405196-36-3)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 405196-36-3(Hazardous Substances Data)

405196-36-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 405196-36-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,0,5,1,9 and 6 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 405196-36:
(8*4)+(7*0)+(6*5)+(5*1)+(4*9)+(3*6)+(2*3)+(1*6)=133
133 % 10 = 3
So 405196-36-3 is a valid CAS Registry Number.

405196-36-3Downstream Products

405196-36-3Relevant articles and documents

Synthesis of functionalized difluoronaphthalenes by regioselective C—H functionalization of 2,3-difluoronaphthalene

Volchkov,Lipkind,Nefedov

, p. 270 - 279 (2020)

2,3-Difluoronaphthalene (1) was selectively converted into 1-methyl-, 1,4-dimethyl-, 1-acetyl-, 1-acetyl-4-methyl-, 1-formyl-, and 1-carboxyl-substituted 2,3-difluoronaphthalenes using lithiation with BuLi as a key step. Nitration and bromination of compound 1 predominantly gave 6,7-difluoro-1-nitronaphthalene and 1-bromo-6,7-difluoronaphthalene, respectively. Regioselectivity of acylation of compound 1 and 2,3-difluoro-1,4-dimethylnaphthalene with AcCl in the presence of AlCl3 dramatically depended on the order of mixing and addition of the reagents. Under the optimized conditions, the yields of 1-(6,7-difluoronaphthalen-1-yl) ethanones and 1-(6,7-difluoronaphthalen-2-yl)ethanones reached 68–93%.

A simple route to 6- and 7-fluoro-substituted naphthalene-1-carboxylic acids

Krülle, Thomas M.,Barba, Oscar,Davis, Susan H.,Dawson, Graham,Procter, Martin J.,Staroske, Thomas,Thomas, Gerard H.

, p. 1537 - 1540 (2008/02/02)

A simple one-pot method for the synthesis of 6-fluoro- and 6,7-difluoro-1-naphthoic acid is described. 6-Fluoro-1-naphthoic acid can be converted into 7-fluoro-1-naphthoic acid in three straightforward steps.

DIHYDROIMIDAZOTHIAZOLE DERIVATIVES

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Page/Page column 64, (2008/06/13)

Compounds of formula (I): or pharmaceutically acceptable salts thereof, exhibit 5-HT1A agonism in addition to noradrenaline reuptake inhibition and optionally also 5-HT reuptake inhibition are useful for the treatment of obesity.

Synthesis of mono- and difluoronaphthoic acids

Tagat, Jayaram R.,McCombie, Stuart W.,Nazareno, Dennis V.,Boyle, Craig D.,Kozlowski, Joseph A.,Chackalamannil, Samuel,Josien, Hubert,Wang, Yuguang,Zhou, Guowei

, p. 1171 - 1177 (2007/10/03)

Aryl carboxamides are useful structural units found in several biologically active compounds. Unlike their benzoic acid counterparts, fluorinated versions of naphthoic acids are relatively unknown. In connection with a recent project, we needed viable syntheses of several mono- and difluorinated naphthoic acids. Herein we describe the synthesis of 5-, 6-, 7-, and 8-fluoro-1-naphthalenecarboxylic acids and 5,7-, 5,8-, 6,7-, and 4,5-difluoro-1-naphthalenecarboxylic acids. The 5-fluoro derivative 1 was obtained from the corresponding 5-bromo compound via electrophilic fluorination of the lithio-intermediate. The rest of the monofluoro (2, 3, and 4) and the difluoro acids (5, 6, and 7) were prepared by a new, general route which entailed the elaboration of commercial fluorinated phenylacetic acids to 2-(fluoroaryl)glutaric acids with differential ester groups; selective hydrolysis to a mono acid, intramolecular Friedel-Crafts cyclization, and aromatization furnished the target structures. An alternative process to assemble a naphthalene skeleton is also presented for the difluoro acids 5 and 6. Finally, 4,5-difluoro-1-naphthalenecarboxylic acid (8) was prepared expeditiously from 1,8-diaminonaphthalene by adapting classical reactions.

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