405230-78-6

Basic information

• Product Name: 3-chloro-2,6-difluoropyridin-4-aMine
• Synonyms: 3-chloro-2,6-difluoropyridin-4-aMine;4-AMino-3-chloro-2,6-difluoropyridine, 98%
• CAS NO: 405230-78-6
• Molecular Formula: C₅H₃ClF₂N₂
• Molecular Weight: 164.5405264
• Mol File: 405230-78-6.mol

Chemical Properties

• Melting Point: 80-84℃
• Appearance: /
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: 3-chloro-2,6-difluoropyridin-4-aMine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-chloro-2,6-difluoropyridin-4-aMine(405230-78-6)
• EPA Substance Registry System: 3-chloro-2,6-difluoropyridin-4-aMine(405230-78-6)

Safety Data

• HazardClass: 9
• Hazardous Substances Data: 405230-78-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3-Chloro-2,6-difluoropyridin-4-amine is used as an intermediate in the synthesis of pharmaceuticals for its potential role in the development of new drugs.
Used in Agrochemical Industry:
3-chloro-2,6-difluoropyridin-4-aMine is utilized as a building block in the production of agrochemicals, contributing to the development of pesticides and other agricultural chemicals.
Used in Dye and Pigment Manufacturing:
3-Chloro-2,6-difluoropyridin-4-amine is employed in the manufacturing of dyes and pigments due to its fluorescent properties, enhancing color characteristics in various applications.
Used in Medicinal Chemistry and Drug Discovery:
Owing to its unique structural properties, 3-chloro-2,6-difluoropyridin-4-amine has potential applications in medicinal chemistry and drug discovery, aiding in the research and development of novel therapeutic agents.
Overall, 3-chloro-2,6-difluoropyridin-4-amine plays a significant role in various industrial and research applications, particularly in the synthesis and development of pharmaceuticals, agrochemicals, dyes, pigments, and in drug discovery processes.

Upstream product

• 2840-00-8 4-amino-3,5-dichloro-2,6-difluoropyridine 
• 1737-93-5 3,5-dichloro-2,4,6-trifluoropyridine 
• 2176-62-7 2,3,4,5,6-pentachloropyridine 

Downstream Products

• 405231-15-4 7-chloro-4,6-difluoro-3-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)imidazo[4,5-c]pyridine 
• 405231-14-3 7-chloro-4,6-difluoro-1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)imidazo[4,5-c]pyridine 

Relevant articles and documents

Preparation method of 4-aminopyridine compound

The invention discloses a preparation method of a 4-aminopyridine compound. The preparation method comprises the following steps: adding a 4-amino- 3-chloropyridine compound or a 4-amino-3, 5-dichloropyridine compound, potassium phosphate and a catalyst into a solvent, and reacting at 0-10 MPa and 0-100 DEG C for 4-12 hours. According to the preparation method of the 4-aminopyridine compound, therelated raw materials are easy to obtain or self-make, the cost is low, the preparation method is simple, the reaction efficiency is high, the raw material cost is low, and byproducts have economic value; meanwhile, the reaction involved in the invention has good universality and tolerance to functional groups.

Selective hydrodechlorination of fluorinated arylamines

Chlorine-containing polyfluorinated anilines and meta-phenylenediamines undergo selective hydrodechlorination easily upon reduction by zinc in aqueous ammonia. A new approach is thus provided to synthetically valuable, partially fluorinated arylamines based on utilizing polyfluorochloroarenes, which are available as intermediates of perfluoroarene production from perchloroarenes. When chlorine atoms are present in positions both ortho and para to the amino group, para chlorine is initially eliminated. Based on this reaction, a one-pot synthesis of partially fluorinated 4-aminopyridines from 3,5-dichlorotrifluoro- and 3-chlorotetrafluoropyridine has been realized.

Novel nucleosides and related processes, pharmaceutical compositions and methods

The invention provides novel nucleosides and related processes, pharmaceutical compositions, and methods. The novel nucleosides are useful in a wide variety of antiviral, antineoplastic, and antibacterial applications. Preferred embodiments of the instant invention include novel 2 halogen-substituted, 3 halogen-substituted, and 2′,3′dihalogen-substituted analogues of 3-deazaadenosine, and novel 3 halogen-substituted analogues of 3-deazaguanosine. Compounds of the instant invention, including 4-Amino-6-fluoro-1-(β-D-ribofuranosyl)imidazo[4,5-c]pyridine and 6-Amino-7-bromo-1,5-dihydro-1-β-D-ribofuranosylimidazo[4,5-c]pyridin-4-one, have exhibited potent antiviral and anticancer activity in vitro. The compounds are also useful in the concomitant treatment of bacterial infections associated with viral infections such as AIDS.

Synthesis of halogen-substituted 3-deazaadenosine and 3-deazaguanosine analogues as potential antitumor/antiviral agents

Various 2-halogen-substituted analogues (38, 39, 43 and 44), 3-halogensubstituted analogues (51 and 52), and 2′,3′ -dihalogen- substituted analogues (57-60) of 3-deazaadenosine and 3-halogen-substituted analogues (61 and 62) of 3-deazaguanosine have been synthesized as potential anticancer and/or antiviral agents. Among these compounds, 3-deaza-3-bromoguanosine (62) showed significant cytotoxicity against L1210, P388, CCRF-CEM and B16F10 cell lines in vitro, producing IC50 values of 3, 7, 9 and 7μM, respectively. Several 3-deazaadenosine analogues (38, 51, 57 and 59) showed moderate to weak activity against hepatitis B virus.