2840-00-8

Basic information

• Product Name: 4-Amino-3,5-dichloro-2,6-difluoropyridine
• Synonyms: 3,5-Dichloro-4-amino-2,6-difluoropyridine;3,5-DICHLORO-2,6-DIFLUORO-4-AMINOPYRIDINE;3,5-dichloro-2,6-difluoro-4-pyridinamine;3,5-DICHLORO-2,6-DIFLUOROPYRIDIN-4-AMINE;4-AMINO-3,5-DICHLORO-2,6-DIFLUOROPYRIDINE;1-AMINO-2,6-DICHLORO-3,5-DIFLUOROBENZENE;2,6-DICHLORO-3,5-DIFLUORO-4-AMINOPYRIDINE;TIMTEC-BB SBB000376
• CAS NO: 2840-00-8
• Molecular Formula: C₅H₂Cl₂F₂N₂
• Molecular Weight: 198.99
• EINECS: 220-630-1
• Product Categories: PYRIDINE
• Mol File: 2840-00-8.mol
• Article Data: 8

Chemical Properties

• Melting Point: 112-114 °C(lit.)
• Boiling Point: 281.7 °C at 760 mmHg
• Flash Point: 124.2 °C
• Appearance: white to light yellow crystal powder
• Density: 1.697 g/cm³
• Vapor Pressure: 0.0035mmHg at 25°C
• Refractive Index: 1.567
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: -3.04±0.10(Predicted)
• CAS DataBase Reference: 4-Amino-3,5-dichloro-2,6-difluoropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Amino-3,5-dichloro-2,6-difluoropyridine(2840-00-8)
• EPA Substance Registry System: 4-Amino-3,5-dichloro-2,6-difluoropyridine(2840-00-8)

Safety Data

• Hazard Codes: Xn,N,Xi
• Statements: 21/22-51/53-36/37/38
• Safety Statements: 36/37-61-36-26
• RIDADR: UN 3077 9/PG 3
• WGK Germany: 2
• HazardClass: IRRITANT
• Hazardous Substances Data: 2840-00-8(Hazardous Substances Data)

Usage

Chemical Properties

white to light yellow crystal powder

Uses

4-Amino-3,5-dichlorodifluoropyridine, is an intermediate in the synthesis of many chemical compounds, such as Fluroxypyr Ethyl Ester, and Fluroxypyr (F598780).

InChI:InChI=1/C5H2Cl2F2N2/c6-1-3(10)2(7)5(9)11-4(1)8/h(H2,10,11)

Upstream product

• 17723-18-1 4-azido-3,5-dichloro-2,6-difluoropyridine 
• 108-67-8 1,3,5-trimethyl-benzene 
• 1737-93-5 3,5-dichloro-2,4,6-trifluoropyridine 
• 2176-62-7 2,3,4,5,6-pentachloropyridine 
• 7664-41-7 ammonia 

Downstream Products

• 63489-58-7 4-amino-2,6-difluoropyridine 
• 405230-78-6 4-amino-3-chloro-2,6-difluoropyridine 
• 1025997-95-8 N²-benzyl-3,5-dichloro-6-fluoro-N²-methyl-pyridine-2,4-diamine 
• 37756-76-6 2-(3,5-dichloro-2,6-difluoro-pyridin-4-ylamino)-5-nitro-benzonitrile 
• 37756-84-6 4-(3,5-dichloro-2,6-difluoro-pyridin-4-ylamino)-3,5-dinitro-benzonitrile 
• 37756-56-2 (3,5-Dichloro-2,6-difluoro-pyridin-4-yl)-(5-fluoro-2,4-dinitro-phenyl)-amine 
• 35622-80-1 4-Amino-3,5-dichlor-2-fluor-6-methoxypyridin 
• 69377-81-7 fluroxypyr 
• 35720-88-8 (3,5-dichloro-2,6-difluoro-pyridin-4-yl)-(3,5-dichloro-2-fluoro-6-phenoxy-pyridin-4-yl)-amine 
• 35622-42-5 (3,5-dichloro-2,6-difluoro-pyridin-4-yl)-(3,5-dichloro-2-fluoro-6-phenylsulfanyl-pyridin-4-yl)-amine 
• 35622-67-4 (2-Benzyloxy-3,5-dichloro-6-fluoro-pyridin-4-yl)-(3,5-dichloro-2,6-difluoro-pyridin-4-yl)-amine 
• 94133-62-7 4-amino-3,5-dichloro-6-fluoro-2-pyridinol 

Relevant articles and documents

Preparation method of 4-aminopyridine compound

The invention discloses a preparation method of a 4-aminopyridine compound. The preparation method comprises the following steps: adding a 4-amino- 3-chloropyridine compound or a 4-amino-3, 5-dichloropyridine compound, potassium phosphate and a catalyst into a solvent, and reacting at 0-10 MPa and 0-100 DEG C for 4-12 hours. According to the preparation method of the 4-aminopyridine compound, therelated raw materials are easy to obtain or self-make, the cost is low, the preparation method is simple, the reaction efficiency is high, the raw material cost is low, and byproducts have economic value; meanwhile, the reaction involved in the invention has good universality and tolerance to functional groups.

Three nitrogen heterocycle containing 1, 2, 3 - thiadiazole - 5 - a amidine compounds and synthesis

The invention discloses an N-trisubstituted-1,2,3-thiadiazole-5-formamidine compound with three aromatic rings of general formula TDCA and a synthesis method of N-trisubstituted-1,2,3-thiadiazole-5-formamidine compound. The target compound of general formula TDCA is obtained by reacting a compound of general formula B and a compound of general formula A, wherein references of X and Y in the general formula A are the same as those in the general formula TDCA.

Selective mono-and diamination of polyfluorinated benzenes and pyridines with liquid ammonia

Amination of pentafluoropyridine, 2,3,5,6-tetrafluoropyridine, 4-chlorotetrafluoropyridine, 3,5-dichlorotrifluoropyridine, octafluorotoluene, α,α,α,2,3,5,6-heptafluorotoluene, decafluoro-m-xylene, decafluorobiphenyl, hexafluorobenzene, and pentafluorobenzene with liquid ammonia was investigated. Bis-aminodefluorination temperatures for the majority of substrates were shown to exceed significantly the corresponding temperatures of monoaminodefluorination. The optimal conditions for selective preparation of mono-and diaminopolyfluoro(het)arenes were elucidated. An efficient method for isolation of particular polyfluorophenylenediamines from product mixtures formed in nonselective reactions of pentafluorobenzene and hexafluorobenzene with aqueous ammonia based on complexation with a crown ether is proposed.