- Ph3P/I2-mediated synthesis of N,N′-disubstituted and N,N,N′-trisubstituted amidines
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A convenient one-pot protocol for the synthesis of N,N′-disubstituted and N,N,N′-trisubstituted amidines is reported. In the presence of the Ph3P–I2/Et3N system, a variety of secondary amides were smoothly reacted with primary or secondary amines to afford the corresponding amidines in good to excellent yields under mild conditions.
- Phakhodee, Wong,Wangngae, Sirilak,Wiriya, Nittaya,Pattarawarapan, Mookda
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supporting information
p. 5351 - 5354
(2016/11/11)
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- AMIDINES. PART XII. BASICITY OF N2-SUBSTITUTED N1,N1-PENTAMETHYLENEBENZAMIDINES IN WATER-ETHANOL SOLUTIONS
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A series of 14 N2-substituted N1,N1-pentamethylenebenzamidines has been synthesized, their pKa values in 99.8percent, 95.6percent and 50percent ethanol measured and correlated with the Hammett ? constants.The influence of composition of binary mixture ethanol-water within the studied range on pKa values, as well as on ρ values obtained is discussed.It was found that the difference of ρ values obtained for these solvents are small, but remarkable.
- Oszczapowicz, Janusz,Raczynska, Ewa,Pawlik, Tadeusz
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p. 117 - 124
(2007/10/02)
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