405923-50-4

Basic information

• Product Name: 7-CHLORO-4-HYDROXY-8-METHYLQUINOLINE-3-CARBOXYLIC ACID
• Synonyms: 7-CHLORO-4-HYDROXY-8-METHYLQUINOLINE-3-CARBOXYLIC ACID;7-Chloro-4-hydroxy-8-methylquinoline-3-carboxylic
• CAS NO: 405923-50-4
• Molecular Formula: C11H8ClNO3
• Molecular Weight: 237.64
• Mol File: 405923-50-4.mol

Chemical Properties

• Boiling Point: 409°C at 760 mmHg
• Flash Point: 201.1°C
• Appearance: /
• Density: 1.48g/cm³
• Vapor Pressure: 2.01E-07mmHg at 25°C
• Refractive Index: 1.632
• PKA: 0.70±0.30(Predicted)
• CAS DataBase Reference: 7-CHLORO-4-HYDROXY-8-METHYLQUINOLINE-3-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 7-CHLORO-4-HYDROXY-8-METHYLQUINOLINE-3-CARBOXYLIC ACID(405923-50-4)
• EPA Substance Registry System: 7-CHLORO-4-HYDROXY-8-METHYLQUINOLINE-3-CARBOXYLIC ACID(405923-50-4)

Safety Data

• Hazardous Substances Data: 405923-50-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
7-CHLORO-4-HYDROXY-8-METHYLQUINOLINE-3-CARBOXYLIC ACID is used as a potential pharmaceutical ingredient for its antibacterial and antifungal properties. Its presence in drug synthesis can contribute to the development of new antibiotics and antifungal agents to combat resistant strains and improve treatment options.
Used in Drug Development:
7-CHLORO-4-HYDROXY-8-METHYLQUINOLINE-3-CARBOXYLIC ACID is used as a building block in drug development due to its hydroxyl and carboxylic acid functional groups. These groups enable further chemical modifications, allowing researchers to create new compounds with enhanced properties and therapeutic effects.
Used in Synthesis of Biologically Active Compounds:
7-CHLORO-4-HYDROXY-8-METHYLQUINOLINE-3-CARBOXYLIC ACID is used as a key intermediate in the synthesis of various biologically active compounds. Its unique structure and functional groups make it a valuable component in the creation of novel molecules with potential applications in medicine and biology.

InChI:InChI=1/C11H8ClNO3/c1-5-8(12)3-2-6-9(5)13-4-7(10(6)14)11(15)16/h2-4H,1H3,(H,13,14)(H,15,16)

Upstream product

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• 5350-94-7 7-chloro-8-methyl-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester 

Relevant articles and documents

Investigations on the 4-quinolone-3-carboxylic acid motif. 2. Synthesis and structure-activity relationship of potent and selective cannabinoid-2 receptor agonists endowed with analgesic activity in vivo

Quinolone-3-carboxamides 11 bearing at position 5, 6, 7, or 8 diverse substituents such as halides, alkyl, aryl, alkoxy, and aryloxy groups differing in their steric/electronic properties, were prepared. The new compounds were tested in vitro for CB1 and

Evaluation of 3-carboxy-4(1H)-quinolones as inhibitors of human protein kinase CK2

Due to the emerging role of protein kinase CK2 as a molecule that participates not only in the development of some cancers but also in viral infections and inflammatory failures, small organic inhibitors of CK2, besides application in scientific research, may have therapeutic significance. In this paper, we present a new class of CK2 inhibitors-3-carboxy-4(1H)-quinolones. This class of inhibitors has been selected via receptor-based virtual screening of the Otava compound library. It was revealed that the most active compounds, 5,6,8-trichloro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (7) (IC 50 = 0.3 μM) and 4-oxo-1,4-dihydrobenzo[h]quinoline-3-carboxylic acid (9) (IC50 = 1 μM), are ATP competitive (Ki values are 0.06 and 0.28 μM, respectively). Evaluation of the inhibitors on seven protein kinases shows considerable selectivity toward CK2. According to theoretical calculations and experimental data, a structural model describing the key features of 3-carboxy-4(1H)-quinolones responsible for tight binding to CK2 active site has been developed.