406-78-0

Basic information

• Product Name: 1,1,2,2-Tetrafluoroethyl 2,2,2-trifluoroethyl ether
• Synonyms: 1,1,2,2-TETRAFLUOROETHYL 2,2,2-TRIFLUOROETHYL ETHER;DAIKIN T-5206;1,1,2,2,5,5,5-Heptafluoro-3-oxapentane;1,1,2,2-Tetrafluoro-1-(2,2,2-trifluoroethoxy)ethane;1,1,2,2-tetrafluoro-2,2,2-trifluoroethylether;HFE-347pc-f;1,1,2,2-Tetrafluoroethyl-2,2,2-trilouroethyl ether;1,1,2,2-Tetrafluoroethyl 2,2,2-trifluoroethyl ether 97%
• CAS NO: 406-78-0
• Molecular Formula: C₄H₃F₇O
• Molecular Weight: 200.05
• Mol File: 406-78-0.mol

Chemical Properties

• Boiling Point: 50 °C
• Flash Point: -6.963 °C
• Appearance: /
• Density: 1.487
• Vapor Pressure: 237mmHg at 25°C
• Refractive Index: 1.276
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C
• CAS DataBase Reference: 1,1,2,2-Tetrafluoroethyl 2,2,2-trifluoroethyl ether(CAS DataBase Reference)
• NIST Chemistry Reference: 1,1,2,2-Tetrafluoroethyl 2,2,2-trifluoroethyl ether(406-78-0)
• EPA Substance Registry System: 1,1,2,2-Tetrafluoroethyl 2,2,2-trifluoroethyl ether(406-78-0)

Safety Data

• Hazard Codes: Xi
• Statements: 10
• Safety Statements: 16
• RIDADR: 3271
• HazardClass: IRRITANT
• PackingGroup: II
• Hazardous Substances Data: 406-78-0(Hazardous Substances Data)

Usage

Chemical Properties

colorless to Almost colorless clear liquid.

Uses

1,1,2,2-Tetrafluoroethyl 2,2,2-Trifluoroethyl Ether can be used as an environmentally friendly solvent, as a cleaning agent, a desiccant, and an auxiliary agent for removing dust or non-condensable gases, etc.

InChI:InChI=1/C4H3F7O/c5-2(6)4(10,11)12-1-3(7,8)9/h2H,1H2

Upstream product

• 116-14-3 polytetrafluoroethylene 
• 75-89-8 2,2,2-trifluoroethanol 

Relevant articles and documents

METHOD FOR PRODUCING FLUORINE-CONTAINING ETHER WITH HIGH PURITY

The present invention provides a method for efficiently producing a highly pure fluoroether containing remarkably low concentration of a fluorine-containing alkyl alcohol. The method is suited for scale-up and specifically includes performing countercurrent separation of a crude solution of fluoroether including a fluorine-containing alkyl alcohol as an impurity using water.

METHOD FOR PRODUCING FLUORINE-CONTAINING ALKYL ETHER

To provide a process for producing a fluorinated alkyl ether, whereby a sufficient reaction rate can be attained even under mild reaction conditions, and a post-process such as distillation after the reaction can be efficiently carried out. A process for producing a fluorinated alkyl ether, which comprises introducing an aprotic polar solvent, a fluorinated ether, a catalyst, a fluorinated alkyl alcohol and a fluorinated olefin into a reactor, and then, reacting the fluorinated alkyl alcohol with the fluorinated olefin, characterized in that the ratio of the two components of the aprotic polar solvent and the fluorinated ether introduced into the reactor is the aprotic polar solvent/the fluorinated ether=5/95 to 80/20 by mass ratio.

METHOD FOR PRODUCING FLUORINE-CONTAINING ALKYL ETHER

A method for producing a fluoroalkyl ether, which comprises reacting a fluoroalkyl alcohol with a fluorinated olefin in the presence of a solvent and a catalyst, wherein the fluoroalkyl alcohol and the fluorinated olefin are continuously supplied into a reactor, a reaction product containing the fluoroalkyl ether is continuously withdrawn from the reactor, and the reaction is carried out while the concentration of the fluoroalkyl alcohol present in the reactor is maintained to be at most 7 mass% based on the total organic component present in the reactor. According to the present invention, a fluoroalkyl ether having a high purity can be produced in an industrial scale and at a high reaction rate.

Polyfluorinated carbocations stabilized by oxygen and sulfur

Polyfluorinated oxonium cations RfCH2OCFX(+) and acyclic perfluorinated sulfonium cations RfSCF2(+) are prepared by the reaction of corresponding ethers or sulfides with antimony pentafluoride in SO2ClF solvent and characterized by 19F and 1H spectroscopy. Based on experimental data the relative stability of polyfluorinated oxonium cations are determined.

Chloropolyfluorodiethyl ethers

Fluorination of 2-chlorodiethyl ether by cobalt trifluoride at 110-150 deg C afforded isomers of 2-chloro-pentafluoro-, -hexafluoro-, and -heptafluoro- diethyl ethers.Chlorine was lost in similar fluorinations of 2-chloro-2,2-difluoroethyl ethyl ether, the only products isolated being a hepta- and a hexa-fluoro diethyl ether.Structures were established spectroscopically. - Keywords: Chloropolyfluorodiethyl ethers; Cobalt trifluoride fluorination

Fluorocarbanion Chemistry. A Versatile Synthesis of Functionalized Fluoro Ketones

Fluorocarbanions generated by the addition of an anion to a fluoro olefin can be trapped by fluoro esters, thereby providing a versatile, one-step synthesis of functionalized fluoro ketones.The most efficient anions include CN-, N3-, C6H5O-, RO-, and RS-.The reaction has been extended in one case to prepare a sulfinate ester.

2.2 Dichloro -1,1,-difluoroethyl-1,2,2,2- tetrofluoroethyl ether as an inhalation anesthetic

This disclosure is directed to novel ethers of the formula: wherein X is fluorine, chlorine or bromine, preferably fluorine, a is 1 or 2, b is 0 or 1, a plus b are 2, preferably both a and b being 1, c is 0 or 1, d is 0 to 2, e is 0 to 2, c plus d plus e are 3, preferably each of c, d, and e is 1, and a plus c are 1 or 2, preferably 2, with the proviso that when e is 1 or 2, X is fluorine or bromine, preferably fluorine. The compounds having less than eight fluorine atoms per molecule are useful as anesthetics, and all of the compounds are useful as solvents and dispersants for fluorinated materials. A highly preferred compound useful as an anesthetic is 1,2,2,2-tetrafluoroethyl 1',1',2'-trifluoro-2'-chloroethyl ether.