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Product FOB Price Min.Order Supply Ability Supplier
High purity 2,2,2-Trifluoroethanol 75-89-8 /manufacturer/low price/high quality/in stock
Cas No: 75-89-8
USD $ 12.0-13.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Hangzhou Dayangchem Co., Ltd. Contact Supplier
High purity 2,2,2-Trifluoroethanol 75-89-8
Cas No: 75-89-8
No Data No Data No Data Hangzhou Yierdechem Co. Ltd Contact Supplier
2,2,2-Trifluoroethanol
Cas No: 75-89-8
No Data 1 Kilogram 1 Metric Ton/Week Henan Allgreen Chemical Co.,Ltd Contact Supplier
High quality Trifluoroethanol supplier in China
Cas No: 75-89-8
No Data No Data No Data Simagchem Corporation Contact Supplier
2,2,2-Trifluoroethanol
Cas No: 75-89-8
No Data No Data No Data Chemwill Asia Co., Ltd. Contact Supplier
2,2,2-Trifluoroethanol
Cas No: 75-89-8
No Data 1 Kilogram 500 Kilogram/Day XinChem Corporation Contact Supplier
2,2,2-Trifluoroethanol CAS: 75-89-8
Cas No: 75-89-8
USD $ 1.0-2.0 / Metric Ton 5 Metric Ton 2500 Metric Ton/Year Henan Sinotech Import&Export Corporation Contact Supplier
lower price Organic synthesis 2,2,2-Trifluoroethanol CAS NO.75-89-8
Cas No: 75-89-8
USD $ 28.0-30.0 / Gram 1 Gram 1000 Metric Ton/Day Crovell Biotech (Hebei) Co., Ltd. Contact Supplier
2.2.2-Trifluoroethanol
Cas No: 75-89-8
USD $ 20.0-30.0 / Gram 10 Gram 200 Metric Ton/Year Jinan Finer Chemical Co., Ltd Contact Supplier
TIANFU-CHEM 2,2,2-Trifluoroethanol
Cas No: 75-89-8
No Data 1 Kilogram 10 Metric Ton/Month Henan Tianfu Chemical Co., Ltd. Contact Supplier

75-89-8 Usage

Chemical properties

Boiling point is 73.6℃, melting point is-43.5℃, refractive index is 1.2940, density (25 ℃) is 1.383g/cm3, enthalpy of evaporation is 37.8kJ/mol.

Hazards & Safety Information

Category: Flammable liquid
Toxicity grading: highly toxic
Acute oral toxicity-rat LD50: 240 mg/kg; Oral-Mouse LD50: 366 mg/kg
Irritation data: Skin-Rabbit 0.75 mg/24 hours and severe; Eyes-rabbit 20 mg/24 hr mild
Flammability hazard characteristics: When meets fire, heat, oxidants, it is flammable; it can burn and generate toxic fluoride fumes.
Storage characteristics: Treasury ventilation low-temperature drying; it should be stored separately with oxidants.
Extinguishing agent: Dry powder, dry sand, carbon dioxide, foam, 1211 fire extinguishing agent.

Preparation method

Since 1933 Swarts used trifluoroacetic anhydride as raw material, catalytic reduction method was used to get trichloroethanol, we have developed a series of synthetic methods. According to the type, the reaction can be divided into three kinds: oxidation, reduction and hydrolysis. According to raw material, it can be divided trifluoroacetic acid method, trifluoroacetyl chloride method, trifluoroacetic anhydride method, trifluoroacetate law, trifluoroacetic acetaldehyde, polyvinylidene fluoride method, trifluoroethane (HFC-143a) method and trifluoro chloroethane (HCFC-133a) method.

Uses

(1) It can be used as import agent of trifluoroethyl and trifluoroacetic ethoxycarbonyl agent, synthetic narcotics fluoride ether (Fluroxene), isoflurane (Isoflurane) and to chlorine halothane (Desflurane), central nervous system stimulants fluticasone Seoul (Flowotyl), proton pump inhibitor lansoprazole (Lansoprazol, pp inhibitors), anti-arrhythmic drugs flecainide with amine (Flecamide), analgesics, benzodiazepines (Quazepam), difficulty urinating therapeutic drug KMD-3213, herbicide trifluoromethyl thiomethyl (Triflusulfuronmethyl).
(2) It can be used for chemical reagents.
(3) It can be used as solvent, it can be used as import agent of trifluoroethyl and trifluoroacetic ethoxycarbonyl agent, it can be also used as pharmaceutical, pesticide intermediates.
(4) It can be used as solvent, it is also used as medicine, pesticide intermediates.

Purification Methods

Dry it with CaSO4 and a little NaHCO3 (to remove traces of acid) and distil it. Highly TOXIC vapour. [Beilstein 1 IV 1370.]

Chemical Properties

Colorless liquid

Uses

In synthesis of medical anaesthetics, pharmaceuticals, and agrochemicals; in polymerizations. Protein denaturant; stabilizes peptide structures. Cleaning solvent; eluent in HPLC separations; working fluid in Rankine heat cycle systems. Environmentally friendly alternative to CFCs.

Description

2,2,2-trifluoroethanol or trifluoroethanol is called TFEA or TEF, it is important intermediate of the fluorine-containing aliphatic, it is colorless, it is miscible liquids with water, it has similar odor with ethanol. Due to the strong electron-withdrawing effect of trifluoromethyl, acid of trifluoromethyl is stronger than ethanol, it can generate hydrogen-bonded stable complex (such as: tetrahydrofuran, pyridine) with heterocyclic compound. Due to this unique physical and chemical properties and special molecular structure, it has different performance with other alcohols, it can participate in a variety of organic reactions, it can be oxidized to acetaldehyde trifluoromethyl or trifluoroacetic acid, it can also provide trifluoromethyl, it can participate in the Still-Gennari improvements of Horner-Wadsworth-Emmons reaction. It has wide range of uses in medicine, pesticides, dyes, energy, and other aspects of organic synthesis.
The main use of trifluoroethanol is as anesthetic, at the earliest, fluorine acetylene ether which synthesized by trifluoroethanol and acetylene takes place of bigger side effects of bromine-fluoro alkanes as anesthetic, and then trichloroethanol is used as raw material to develop non-flammable, low toxicity isoflurane alkanes and high performance of the new anesthetic of chlorofluoroalkane. Trifluoroethanol can be introduced into drug structure as trifluoromethyl of functional group, it can generate significant physiological activity, increase fat-soluble of molecules, improve efficacy or reduce side effects of the organism, its synthetic drugs have central nervous system stimulants fluticasone Seoul, substituted pyridines stomach cytoplasmic proton pump inhibitor Lansoprazole and Pariprazole, antiarrhythmic drugs flecainide with amines and analgesic drugs benzodiazepines and dysuria treatment KMD-3212 and so on.
InChI:InChI=1/C2H3F3O/c3-2(4,5)1-6/h6H,1H2

75-89-8 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
Fluka (05841)  2,2,2-Trifluoroethanol  eluent additive for LC-MS 75-89-8 05841-50ML 1,565.46CNY Detail
Fluka (05841)  2,2,2-Trifluoroethanol  eluent additive for LC-MS 75-89-8 05841-10X1ML 983.97CNY Detail
Sigma-Aldrich (91683)  2,2,2-Trifluoroethanol  analytical standard, for NMR spectroscopy 75-89-8 91683-100ML 4,120.74CNY Detail
Sigma-Aldrich (91683)  2,2,2-Trifluoroethanol  analytical standard, for NMR spectroscopy 75-89-8 91683-25ML 1,124.37CNY Detail
Alfa Aesar (L16898)  2,2,2-Trifluoroethanol, NMR grade, 99.5%    75-89-8 100g 738.0CNY Detail
Alfa Aesar (L16898)  2,2,2-Trifluoroethanol, NMR grade, 99.5%    75-89-8 25g 284.0CNY Detail
Alfa Aesar (L16898)  2,2,2-Trifluoroethanol, NMR grade, 99.5%    75-89-8 5g 159.0CNY Detail
Alfa Aesar (A10788)  2,2,2-Trifluoroethanol, 99+%    75-89-8 1000g 2805.0CNY Detail
Alfa Aesar (A10788)  2,2,2-Trifluoroethanol, 99+%    75-89-8 500g 1558.0CNY Detail
Alfa Aesar (A10788)  2,2,2-Trifluoroethanol, 99+%    75-89-8 100g 389.0CNY Detail
Alfa Aesar (A10788)  2,2,2-Trifluoroethanol, 99+%    75-89-8 50g 203.0CNY Detail
TCI America (T0435)  2,2,2-Trifluoroethanol  >99.0%(GC) 75-89-8 500g 1,260.00CNY Detail

75-89-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 2,2,2-trifluoroethanol

1.2 Other means of identification

Product number -
Other names Trifluoroethyl alcohol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Intermediates,Paint additives and coating additives not described by other categories
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:75-89-8 SDS

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