- Synthesis of a new water soluble 2,2-bifunctionalized spin label and its application to troponin C
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A new water soluble 2,2-bifunctionalized spin label (2,2E-BSL) having pyrrolidine nitroxide moiety was synthesized starting from a nitro compound with two hydroxymethyl group converted to the linkers of the 2,2E-BSL, and was applied to label troponin C (TnC). Labeled TnC through two linkages were successfully isolated, and 2,2E-BSL was proved to be immobilized on TnC by EPR measurement. Copyright
- Hirayama, Tasuku,Taki, Masayasu,Nakamura, Motoyoshi,Arata, Toshiaki,Yamamoto, Yukio
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- An Alkene-Forming Cascade Reaction en Route to 2,2'-Bi(glycerol)
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Synthesis of 2,3-bis(hydroxymethyl)butane-1,2,3,4-tetraol is of great interest because of its utility as a potential precursor to new dendrimers, in the preparation of unnatural lipids, and in the synthesis of open-framework coordination polymers. Synthesis of this new six-hydroxyl compound is achieved in four steps from commercially available starting materials. In this process, a new olefin-forming cascade reaction was discovered.
- Li, Xiaoxun,Livant, Peter D.,Chen, Jianjun
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p. 1769 - 1772
(2018/08/17)
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- A PROCESS FOR MAKING 2-NITRO-1-ETHANOL DERIVATIVES
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A process for making a 2-nitro-1-ethanol derivative of formula III: wherein R3 is as described herein is provided. Novel 2-nitro-1-ethanol derivatives provided.
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Page/Page column 8
(2012/10/18)
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- Indium-mediated reaction of 1-bromo-1-nitroalkanes with aldehydes: Access to 2-nitroalkan-1-ols
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A novel method for the preparation of 2-nitroalkan-1-ols by an indium-promoted reaction of bromonitromethane with a variety of aldehydes is reported. The reaction was also performed with 2-bromo-2-nitropropanes to afford 2,2-dialkyl-2-nitroalkan-1-ols. The use of chiral sugar-derived aldehydes furnished the corresponding 2-nitroalkan-1-ols with excellent stereoselectivity. The utility of the novel sugar-derived 2,2-dialkyl-2-nitroalkan-1-ols for the preparation of branched iminosugar derivatives was demonstrated by the preparation of a hydroxymethyl branched polyhydroxylated azepane.
- Soengas, Raquel G.,Estevez, Amalia M.
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experimental part
p. 5190 - 5196
(2010/11/02)
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- An efficient total synthesis of a sphingosine-1-phosphate receptor agonist KRP-203
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An efficient total synthesis of the S1P1 agonist, KRP-203, is described. The key step involves the conjugate addition of diethyl acetamidomalonate to a styrene compound to give the core structure of KRP-203. Multigram quantities of the targeted KRP-203, sufficient for several biological studies, were obtained in six steps with an overall yield of 58%.
- Chino, Masao,Kiuchi, Masatoshi,Adachi, Kunitomo
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p. 3859 - 3866
(2008/09/21)
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- Intermolecular nitroso Diels-Alder cycloaddition of α-acetoxynitroso derivatives in aqueous medium
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The Diels-Alder cycloadditions of the α-acetoxynitroso dienophile 1 in water are reported. The rapid and high yielding synthesis of structurally diverse 3,6-dihydro-1,2-oxazines complements the straightforward elaboration of aminoalcohols obtained from th
- Calvet, Geraldine,Guillot, Regis,Blanchard, Nicolas,Kouklovsky, Cyrille
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p. 4395 - 4401
(2007/10/03)
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- New submonomers for poly N-substituted glycines (peptoids)
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Five protected submonomers for peptoid synthesis were prepared, including N(in)-BOC-tryptamine, O-t-butyl tyramine, PMC-guanidino- propylamine, 6-amino-6-deoxy-D-galactopyranose diacetonide, and 5-amino-2,2- dimethyl-1,3-dioxane. The first three mimic nat
- Uno, Tetsuo,Beausoleil, Eric,Goldsmith, Richard A.,Levine, Barry H.,Zuckermann, Ronald N.
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p. 1475 - 1478
(2007/10/03)
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- Preparation and antiparasitic activity of new imidazoles bearing dioxane or hexahydropyrimidine moiety
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5-Nitro-1,3-dioxane and 5-nitrohexahydropyrimidine salts are found to be suitable nucleophiles for S(RN)1 reactions. From C-alkylation products, base-promoted nitrous acid elimination and acid-catalyzed cleavage of the resulting acetals afford new compounds. Only the imidazole derivatives exhibit significant amoebicide and trichomonacide activities. Structure-activity relationships are discussed.
- Vanelle,Maldonado,Crozet,Senouki,Delmas,Gasquet,Timon-David
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p. 709 - 714
(2007/10/02)
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- Novel process for the preparation of serinol
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A process of forming 2-amino-1,3-propanediol by reducing the compound, 5-nitro-1,3-dioxane and subsequently hydrolyzing the reduced compound.
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- Novel process for the preparation of bronopol
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A process of forming 2-bromo-2-nitro-1,3-propanediol by contacting a 5-nitro-1,3-dioxane with bromine under alkaline conditions and hydrolyzing the brominated product.
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- SUR LA REACTIVITE DE gem-BROMONITROALCANES EN PRESENCE DE THIOLATES.
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Reactions between various gem-bromonitro alcanes BrA1'-4 in the presence of t-C4H9S(1-) are shown to proceed at low temperature via either both radical coupling and SRN1 or radical coupling only and to lead efficiently to (A1'-4)2.
- Amrollah-Madjdabadi, Ali,Beugelmans, Rene,Lechevallier, Andre
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p. 4525 - 4528
(2007/10/02)
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- Direct and Efficient Preparation of gem-Chloronitro Compounds or Nitro Compounds from gem-Bromonitro Compounds
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Sodiumethanethiolate in methanol is an efficient reducing agent for gem-bromonitro compounds; treatment of the resultant nitronates with a protic acid or with N-chlorosuccinimide gives high yields of the corresponding nitro or gem-chloronitro compounds, respectively.
- Amrollah-Madjdabadi, A.,Beugelmans, R.,Lechevallier, A.
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p. 826 - 828
(2007/10/02)
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