4064-87-3

Usage

Uses

Used in Organic Synthesis:
2,2-DIMETHYL-5-NITRO-1,3-DIOXANE is utilized as a reagent in organic synthesis for its capacity to participate in various chemical reactions, contributing to the formation of a range of organic compounds.
Used in Pharmaceutical Production:
In the pharmaceutical industry, 2,2-DIMETHYL-5-NITRO-1,3-DIOXANE serves as a raw material, playing a crucial role in the synthesis of different medicinal agents, underlining its importance in drug development.
Used in Agrochemical Production:
Similarly, in agrochemical manufacturing, 2,2-DIMETHYL-5-NITRO-1,3-DIOXANE is employed as a starting material, highlighting its versatility in the creation of compounds used in agricultural applications to protect crops and enhance yields.
Safety Considerations:
Given its explosive nature, 2,2-DIMETHYL-5-NITRO-1,3-DIOXANE is used with caution, requiring adherence to strict safety guidelines during its handling, storage, and use to prevent accidents and ensure the well-being of individuals in proximity.

Upstream product

• 1794-90-7 2-nitropropane-1,3-diol 
• 67-64-1 acetone 
• 60766-57-6 2,2-dimethyl-5-bromo-5-nitro-1,3-dioxane 
• 4728-14-7 2,2-dimethyl-5-hydroxymethyl-5-nitro-1,3-dioxane 
• 100-52-7 benzaldehyde 

Downstream Products

• 104143-48-8 2,2-dimethyl 5-nitro 5-p-nitrobenzyl 1,3-dioxane 
• 104440-15-5 2,2-dimethyl-5-nitro-5-phenylazo-[1,3]dioxane 
• 106377-87-1 2,2-dimethyl-5-nitro-5-p-tolylazo-[1,3]dioxane 
• 104622-21-1 5-(4-chloro-phenylazo)-2,2-dimethyl-5-nitro-[1,3]dioxane 
• 104912-19-8 2,2-dimethyl-5-nitro-5-(4-nitro-phenylazo)-[1,3]dioxane 
• 107821-92-1 2,2-dimethyl-5-nitro-5-[4-(4-nitro-phenylsulfanyl)-phenylazo]-[1,3]dioxane 
• 5086-75-9 2,2-dimethyl-5,5-dinitro-1,3-dioxane 
• 40137-24-4 5-amino-2,2-di-methyl-1,3-dioxane 
• 1023648-25-0 5-(2-{4-[3-(benzyloxy)phenylthio]-2-chlorophenyl}ethyl)-2,2-dimethyl-5-nitro[1,3]dioxane 
• 139157-69-0 1-methyl 2-(2,2-dimethyl 1,3-dioxane 5-ylidenemethyl) 5-nitroimidazole 
• 104143-49-9 2,2-dimethyl 5-p-nitrobenzylidene 1,3-dioxane 
• 1026324-26-4 3-(2,2-Dimethyl-[1,3]dioxan-5-ylcarbamoyl)-indazole-1-carboxylic acid benzyl ester 

Relevant academic research and scientific papers

Synthesis of a new water soluble 2,2-bifunctionalized spin label and its application to troponin C

A new water soluble 2,2-bifunctionalized spin label (2,2E-BSL) having pyrrolidine nitroxide moiety was synthesized starting from a nitro compound with two hydroxymethyl group converted to the linkers of the 2,2E-BSL, and was applied to label troponin C (TnC). Labeled TnC through two linkages were successfully isolated, and 2,2E-BSL was proved to be immobilized on TnC by EPR measurement. Copyright

An Alkene-Forming Cascade Reaction en Route to 2,2'-Bi(glycerol)

Synthesis of 2,3-bis(hydroxymethyl)butane-1,2,3,4-tetraol is of great interest because of its utility as a potential precursor to new dendrimers, in the preparation of unnatural lipids, and in the synthesis of open-framework coordination polymers. Synthesis of this new six-hydroxyl compound is achieved in four steps from commercially available starting materials. In this process, a new olefin-forming cascade reaction was discovered.

A PROCESS FOR MAKING 2-NITRO-1-ETHANOL DERIVATIVES

A process for making a 2-nitro-1-ethanol derivative of formula III: wherein R3 is as described herein is provided. Novel 2-nitro-1-ethanol derivatives provided.

Indium-mediated reaction of 1-bromo-1-nitroalkanes with aldehydes: Access to 2-nitroalkan-1-ols

A novel method for the preparation of 2-nitroalkan-1-ols by an indium-promoted reaction of bromonitromethane with a variety of aldehydes is reported. The reaction was also performed with 2-bromo-2-nitropropanes to afford 2,2-dialkyl-2-nitroalkan-1-ols. The use of chiral sugar-derived aldehydes furnished the corresponding 2-nitroalkan-1-ols with excellent stereoselectivity. The utility of the novel sugar-derived 2,2-dialkyl-2-nitroalkan-1-ols for the preparation of branched iminosugar derivatives was demonstrated by the preparation of a hydroxymethyl branched polyhydroxylated azepane.

An efficient total synthesis of a sphingosine-1-phosphate receptor agonist KRP-203

An efficient total synthesis of the S1P1 agonist, KRP-203, is described. The key step involves the conjugate addition of diethyl acetamidomalonate to a styrene compound to give the core structure of KRP-203. Multigram quantities of the targeted KRP-203, sufficient for several biological studies, were obtained in six steps with an overall yield of 58%.

Intermolecular nitroso Diels-Alder cycloaddition of α-acetoxynitroso derivatives in aqueous medium

The Diels-Alder cycloadditions of the α-acetoxynitroso dienophile 1 in water are reported. The rapid and high yielding synthesis of structurally diverse 3,6-dihydro-1,2-oxazines complements the straightforward elaboration of aminoalcohols obtained from th

New submonomers for poly N-substituted glycines (peptoids)

Five protected submonomers for peptoid synthesis were prepared, including N(in)-BOC-tryptamine, O-t-butyl tyramine, PMC-guanidino- propylamine, 6-amino-6-deoxy-D-galactopyranose diacetonide, and 5-amino-2,2- dimethyl-1,3-dioxane. The first three mimic nat

Preparation and antiparasitic activity of new imidazoles bearing dioxane or hexahydropyrimidine moiety

5-Nitro-1,3-dioxane and 5-nitrohexahydropyrimidine salts are found to be suitable nucleophiles for S(RN)1 reactions. From C-alkylation products, base-promoted nitrous acid elimination and acid-catalyzed cleavage of the resulting acetals afford new compounds. Only the imidazole derivatives exhibit significant amoebicide and trichomonacide activities. Structure-activity relationships are discussed.

Novel process for the preparation of serinol

A process of forming 2-amino-1,3-propanediol by reducing the compound, 5-nitro-1,3-dioxane and subsequently hydrolyzing the reduced compound.

Novel process for the preparation of bronopol

A process of forming 2-bromo-2-nitro-1,3-propanediol by contacting a 5-nitro-1,3-dioxane with bromine under alkaline conditions and hydrolyzing the brominated product.