40812-76-8

Usage

Uses

3-Hydroxybenzoyl Chloride is a useful reagent in preparation and the biological activities of substituted 1,3,4-oxadiazole derivatives.

Upstream product

• 99-06-9 3-Carboxyphenol 
• 75-44-5 phosgene 
• 100-83-4 meta-hydroxybenzaldehyde 
• 1700-37-4 3-Benzyloxybenzaldehyde 

Downstream Products

• 19438-10-9 methyl 3-hydroxybenzoate 
• 7781-98-8 ethyl-3-hydroxybenzoate 
• 618-49-5 3-hydroxybenzamide 
• 24262-63-3 salol 
• 6665-68-5 5,3’-dihydroxyfIavone 
• 939386-91-1 C₁₇H₁₆N₂O₂ 
• 24781-23-5 3-acetoxybenzoic acid methyl ester 
• 15789-04-5 N,N-diethyl-3-hydroxybenzamide 
• 1261479-29-1 C₂₀H₁₄N₂O₅S 
• 13161-32-5 4-hydroxy-3H-isobenzofuran-1-one 
• 4792-33-0 4-methoxyphthalide 
• 62924-93-0 N,N-diethyl-3-methoxybenzamide 
• 70946-15-5 N,N-diethyl 2-formyl-3-methoxybenzamide 
• 6616-44-0 2-(3-hydroxyphenyl)benzimidazole 

Relevant academic research and scientific papers

Hydroxybenzoyl Chlorides in the Synthesis of Conjugates with Biologically Active Dipeptides

Abstract: Conjugates of hydroxy- and acetoxybenzoic acids with dipeptides based on 4-aminobutanoic acid and glycine were synthesized through hydroxy(acetoxy)benzoyl chlorides and 4-[hydroxy(acetoxy)benzoyl-amino]butanoyl chlorides as intermediate products. Acyl chlorides were prepared by treatment of the corre-sponding acids with oxalyl chloride in the presence of dimethylformamide at a ratio of 1:1.1:0.07 in boiling benzene. The target N-[hydroxy(acetoxy)benzoyl] derivatives of dipeptides were obtained with high yields, and no further purification of the products was necessary. The synthesized compounds were evaluated as potential neuroprotective agents.

Total Synthesis and Biological Evaluation of Tiancimycins A and B, Yangpumicin A, and Related Anthraquinone-Fused Enediyne Antitumor Antibiotics

The family of anthraquinone-fused enediyne antitumor antibiotics was established by the discovery of dynemicin A and deoxy-dynemicin A. It was then expanded, first by the isolation of uncialamycin, and then by the addition to the family of tiancimycins A-

Discovery of novel phenoxybenzamide analogues as Raf/HDAC dual inhibitors

Histone deacetylase (HDAC)inhibitors as an important epigenetic therapeutic strategy affect signaling networks and act synergistically with kinase inhibitors for the treatment of cancer. Herein we presented a series of novel phenoxybenzamide analogues with inhibition of Raf and HDAC. Among them, compound 10e showed potent antiproliferative activities against Hepg2 and MDA-MB-468 in cellular assays. This work may lay the foundation for developing novel dual Raf/HDAC inhibitors as potential anticancer therapeutics.

Uracil Hydroxybenzamides as Potential Antidiabetic Prodrugs

A series of N1, N3-bis-hydroxybenzoyl, -acetoxybenzoyl, and -methoxybenzoyl uracil derivatives were synthesized. All compounds were screened for the ability to rupture protein cross links and antiglycating, chelating, and antiaggregant properties, which are most significant for pharmacological treatment of thrombosis and angio-, nephro-, encephalo-, and cardiopathies. 1,3-bis-(4-Methoxybenzoyl)pyrimidine-2,4(1H,3H)-dione was a promising antidiabetic agent with all studied activities.

A synthesis method of benzaldehyde (by machine translation)

The invention provides a synthesis method of benzaldehyde, the method comprises: (1) the hydroxy benzoic acid as the raw material, N, N - dimethyl formamide or N, N - dimethyl acetamide as catalyst, in the presence of acyl, to carry out the following formula 1 shown between the acyl chloride reaction in order to produce hydroxy benzoyl chloride; and (2) in the presence of hydrogen, in the presence of a catalyst, in the step (1) the resulting hydroxy benzoyl chloride of the following carried out 2 is shown between the hydrogenation reduction reaction of benzaldehyde. According to the method of the present invention mild condition, few steps, synthetic high yield, production process has no waste water, compared with the traditional method, the advantages of environmental protection, energy-saving high-efficiency, small equipment footprint, the product quality is in quality. [Formula 1] [Formula 2] (by machine translation)

New preparation method of 3-hydroxybenzoyl chloride

The invention relates to a new preparation method of 3-hydroxybenzoyl chloride, belonging to the technical field of medical technology. The invention relates to a more advanced new preparation methodof the 3-hydroxybenzoyl chloride. In order to solve the

3-Aryl-1,2,4-oxadiazole Derivatives Active Against Human Rhinovirus

The human rhinovirus (hRV) is the causative agent of the common cold that often aggravates respiratory complications in patients with asthma or chronic obstructive pulmonary disease. The high rate of mutations and variety of serotypes are limiting the development of anti-hRV drugs, which emphasizes the need for the discovery of novel lead compounds. Previously, we identified antiviral compound 1 that we used here as the starting material for developing a novel compound series with high efficacy against hRV-A and -B. Improved metabolic stability was achieved by substituting an ester moiety with a 1,2,4-oxadiazole group. Specifically, compound 3k exhibited a high efficacy against hRV-B14, hRV-A21, and hRV-A71, with EC50 values of 66.0, 22.0, and 3.7 nM, respectively, and a relevant hepatic stability (59.6 and 40.7% compound remaining after 30 min in rat and human liver microsomes, respectively). An in vivo study demonstrated that 3k possessed a desirable pharmacokinetic profile with low systemic clearance (0.158 L·h-1·kg-1) and modest oral bioavailability (27.8%). Hence, 3k appears to be an interesting candidate for the development of antiviral lead compounds.

M-hydroxy acetophenone preparation method

The invention discloses an m-hydroxy acetophenone preparation method which includes the steps: performing chlorination, dissolving m-hydroxybenzoic acid in methylbenzene, adding 4-dimethylamino pyridine serving as a catalyst, adding acyl thionyl chloride for chlorination to obtain m-hydroxybenzoic acid acyl chloride, and then removing the acyl thionyl chloride by concentration and evaporation to obtain m-hydroxybenzoic acid acyl chloride-methylbenzene solution; dissolving dimethyl malonate sodium salt in methylbenzene to obtain dimethyl malonate sodium salt-methylbenzene solution, dripping them-hydroxybenzoic acid acyl chloride-methylbenzene solution obtained in the step (1) into the dimethyl malonate sodium salt-methylbenzene solution, and then performing reflux reaction for 3-5 hours atthe reaction temperature of 50-80 DEG C to obtain a product A; adding the obtained product A into hydrochloric acid solution, and performing hydrolysis reaction to obtain m-hydroxy acetophenone. Thepreparation method is simple in process, small in wastewater discharge amount, low in cost and high in yield and final product purity.

Evaluation of N-Hydroxy-, N-Metoxy-, and N-Acetoxybenzoyl-Substituted Derivatives of Thymine and Uracil as New Substances for Prevention and Treatment of Long-Term Complications of Diabetes Mellitus

New uracil and thymine derivatives, N1-,N3- and N1,N3-(RO-benzoyl)-(1H,3H)-pyrimidine- 2,4-diones, were synthesized (RO- is hydroxy, acetoxy- or methoxy-group). The compounds were studied in a complex of in vitro tests for the ability to inhibit the development of long-term complications of diabetes. Their ability to cleave cross-links of proteins has been evaluated. The most significant ways of pharmacological correction of thrombosis, angio-, nephro-, encephalo-, and cardiopathy, antiglycation, chelating, and antiplatelet activities, have been established. The most active compound in terms of antiplatelet action, N1- hydroxybenzoyluracil, exceeded acetylsalicylic acid by ~44%. In terms of their ability to chelate copper (II) cations, all compounds (with the exception of 1,3-bis(3-hydroxybenzoyl)-(1H,3H)-pyrimidine-2,4-dione that was not not studied in this test) showed the activity, whose IC50 fell in the range between that for pioglitazone (44.1 μM) and pyridoxamine (136.7 μM) comparison drugs. The best antiglycation effect at the 1 mM concentration was observed for N1,N3-bismethoxy- and N1,N3-bisacetoxybenzoyl derivatives of thymine. The maximum activity to cleave cross-links of proteins (C = 1 mM), comparable to that of alagebrium, was established for 1,3-bis(4-methoxybenzoyl)uracil, for which also high rates of other estimated activities were noted. Thus, the N1-,N3- and N1,N3-(RO-benzoyl) derivatives of uracil and thymine are promising basiсs for creating drugs that suppress the development of long-term complications of diabetes.

Iridium(I)-Catalyzed Intramolecular Hydrocarbonation of Alkenes: Efficient Access to Cyclic Systems Bearing Quaternary Stereocenters

A catalytic, versatile and atom-economical C?H functionalization process that provides a wide variety of cyclic systems featuring methyl-substituted quaternary stereocenters is described. The method relies on the use of a cationic IrI–bisphosph