- Wacker oxidation methodology for the synthesis of the benzo-fused acetal core of marticin
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Methodology for the synthesis of the benzo-fused acetal core of marticin is described in this paper. Condensation of readily available 1-(2-allyl-3,6- dimethoxyphenyl)ethanone with diethyl oxalate under Claisen condensation conditions furnished (Z)-ethyl
- Pillay, Adushan,Rousseau, Amanda L.,Fernandes, Manuel A.,De Koning, Charles B.
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experimental part
p. 7116 - 7121
(2012/08/28)
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- Convenient synthetic route to antimicrobial benzopyranquinones
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A general synthetic strategy has been developed for the synthesis of racemic 3,4-dihydro-3-methyl-1H-benzopyran-5,8-dione 25, trans-(1R,3R)-5,8-dihydroxy-1,3-dimethyl-4-oxo-1H-benzopyran 39, rel (1R,3R,4R)-3,4-dihydro-1,3-dimethyl-4-hydroxy-1H-benzopyran-5,8-dione 41 and the rel-(4S)-diastereoisomer 42.
- Green, Ivan R.,Hugo, Victor I.,Oosthuisen, Francois J.,Eeden, Nestor van,Giles, Robin G. F.
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- Leukotriene receptor antagonists. 1. Synthesis and structure-activity relationships of alkoxyacetophenone derivatives
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A series of derivatives of 2,4-dihydroxy-3-propylacetophenone were prepared and examined for their ability to block leukotriene D4 (LTD4) induced contraction of guinea pig ileum. Straight-chain carboxylic acids where the carboxyl gro
- Marshall,Goodson,Cullinan,Swanson-Bean,Haisch,Rinkema,Fleisch
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p. 682 - 689
(2007/10/02)
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- Allylation of 2-Alkanoyl 1,4-Quinones with Allylsilanes and Allylstannanes. Efficient Synthesis of Pyranonaphthoquinone Antibiotics
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Total syntheses of pyranonaphthoquinone antibiotics eleutherin, isoeleutherin, nanaomycin A, and deoxyfrenolicin are described.The crucial step in the route is a regioselective allylation of alkanoyl quinones with allylsilanes and allylstannanes.The allyl
- Uno, Hidemitsu
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p. 350 - 358
(2007/10/02)
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- LEWIS ACID MEDIATED ALLYLATION OF 2-ALKANOYL-1,4-QUINONES WITH ALLYLSILANE AND ALLYLSTANNANE
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Allyltrimethylstannane reacts with 2-alkanoyl-1,4-quinones regioselectively to afford conjugate addition products which can be derived to 2-alkanoyl-3-allylhydroquinone diacetate, while allyltriphenylsilane reacts with the quinone to give naphthofuran.
- Naruta, Yoshinori,Uno, Hidemitsu,Maruyama, Kazuhiro
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p. 5221 - 5224
(2007/10/02)
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- Claisen Rearrangement of meta-Substituted Allyl Phenyl Ethers
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Electron-releasing substituents at the 3-position of allyl phenyl ethers favour Claisen rearangement of the allyl group to the 6-position, whereas electron-acceptors favour migration to the 2-position. 2-Acylhydroquinone 4-allyl ethers yield, predominantly, the 3-allyl isomers, probably because internal hydrogen bonding confers naphthalenoid character on the aryl residue.
- Bruce, J. Malcolm,Roshan-Ali, Yusuf
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p. 2677 - 2679
(2007/10/02)
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