- Selective metalation of phenol-type proligands for preparative organometallic chemistry
-
The selective C-metalation of phenol ester derived proligands is a readily applicable addition to state-of-the-art protocols toward cyclometalated structures, in particular of the base metals. The approach is demonstrated by the ortho-nickelation of a 1,10-phenanthroline based strong-field ligand platform that is a sought-after motif in the field of base-metal photochemistry.
- Berkefeld, Andreas,Fr?hlich, Markus,Kordan, Mike,H?rner, Gerald,Schubert, Hartmut
-
p. 3987 - 3990
(2020/04/17)
-
- Development of Chiral C2-Symmetric N-Heterocyclic Carbene Rh(I) Catalysts through Control of Their Steric Properties
-
Chiral square-planar Rh(I) complexes based on new C2-symmetric NHC ligands have been synthesized selectively in a few steps as single diastereoisomers. These chiral precatalysts were applied to the asymmetric transfer hydrogenation of 1-phenylp
- Abadie, Marc-Antoine,Macintyre, Kirsty,Boulho, Cédric,Hoggan, Peter,Capet, Frédéric,Agbossou-Niedercorn, Francine,Michon, Christophe
-
supporting information
p. 536 - 543
(2019/01/14)
-
- Preparation of a novel bromine complex and its application in organic synthesis
-
Although molecular bromine (Br2) is a useful brominating reagent, it is not easy to handle. Herein, we describe the preparation of a novel air-stable bromine complex prepared from 1,3-dimethyl-2-imidazolidinone (DMI) and Br2, which was identified to be (DMI)2HBr3 by spectral and X-ray techniques. This complex was then used to brominate olefins, carbonyl compounds, and aromatics, as well as in the Hofmann rearrangement. Yields of reaction products using this complex were almost the same or superior to those using other bromine alternatives.
- Nishio, Yuya,Yubata, Kotaro,Wakai, Yutaro,Notsu, Kotaro,Yamamoto, Katsumi,Fujiwara, Hideki,Matsubara, Hiroshi
-
p. 1398 - 1405
(2019/02/07)
-
- Atom-economical brominations with tribromide complexes in the presence of oxidants
-
Bromination is an important transformation in organic synthesis, and novel efficient bromination techniques are still required. Herein, we demonstrate atom-economical brominations using (DMI)2HBr3, a novel tribromide complex, with oxidants such as DMSO and Oxone. Using this system, olefinic and aromatic brominations, as well as selective α-monobrominations of ketones proceeded well to afford the desired bromides in good yields. Importantly, in these reactions all of the bromine atoms in this complex are used to brominate.
- Yubata, Kotaro,Matsubara, Hiroshi
-
supporting information
p. 1001 - 1004
(2019/03/13)
-
- NOVEL LIGAND COMPOUND AND TRANSITION METAL COMPOUND COMPRISING THE SAME
-
The present invention relates to a novel ligand compound and a transition metal compound including the same. The transition metal compound with a novel structure according to the present invention can be used as a polymerization reaction catalyst when an olefin polymer is manufactured. The novel ligand compound has a structure in which two biphenyl-2-ols are connected to pyridine by methylene, respectively. An oxygen atom of biphenyl-2-ol is covalently bonded to the transition metal and a nitrogen atom of pyridine is coordinately bonded to the transition metal.COPYRIGHT KIPO 2018
- -
-
Paragraph 0143-0144; 0150-0151
(2018/05/24)
-
- Substituted Pyrrolidines and Methods of Use
-
The invention discloses compounds of Formula (I) wherein R1, R2, R2A, R3, R3A, R4, and R5 are as defined herein. The present invention relates to compounds and their use in the treatment of cystic fibrosis, methods for their production, pharmaceutical compositions comprising the same, and methods of treating cystic fibrosis by administering a compound of the invention.
- -
-
Paragraph 2122
(2018/04/20)
-
- UREA DERIVATIVES USEFUL AS KINASE INHIBITORS
-
There are provided compounds of formula I, wherein R1, R1A, R1C to R1E, Ra, Rb, X1, E and G have meanings given in the description, which compounds have antiinflammatory activity (e.g. through inhibition of one or more of members of: the family of p38 mitogen-activated protein kinase enzymes; Syk kinase; and members of the Src family of tyrosine kinases) and have use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, eye and intestines.
- -
-
Page/Page column 59
(2015/07/07)
-
- Synthesis of dilactone bridged terphenyls with crankshaft architectures
-
Three highly fluorescent dilactone bridged terphenyls with crankshaft architectures have been synthesized. This general class of compounds is relatively unexplored. These compounds have been characterized by fluorescence and UV-vis spectroscopy. For all three compounds, a direct correlation between the rigidity of the terphenyl system and the strength of absorption and emission of light has been observed. Preliminary studies have indicated that compounds with this architecture have the potential to be useful as pH-driven molecular switches and/or sensors with instant fluorescence attenuation at high pH values.
- Dressler, Justin J.,Miller, Sarah A.,Meeuwsen, Brian T.,Riel, Asia Marie S.,Dahl, Bart J.
-
supporting information
p. 283 - 292
(2015/02/02)
-
- Aryl Derivatives And Uses Thereof
-
The present invention relates to antimalarial compounds and their use against protozoa of the genus Plasmodium, including drug-resistant Plasmodia strains. This invention further relates to compositions containing such compounds and a process for making the compounds.
- -
-
Paragraph 0153
(2014/05/20)
-
- HETEROARYL DERIVATIVES AND USES THEREOF
-
The present invention relates to antimalarial compounds and their use against protozoa of the genus Plasmodium, including drug-resistant Plasmodia strains. This invention further relates to compositions containing such compounds and a process for making the compounds.
- -
-
Paragraph 0238; 0239
(2014/05/20)
-
- PHOSPHORESCENT MATERIAL, THEIR PREPARATIONS AND APPLICATIONS
-
The subject invention is directed to tetradentate bis-(NHC carbenes) alkylene ligand Pt(II) complexes, tetradentate bis-(NHC carbenes) alkylene ligands, and its ligand precursors, for preparation of the Pt(II) complexes. The Pt(II) complexes show a deep blue emission with an improved quantum efficiency and can be used for fabrication of OLEDs with an electroluminescence layer that comprise the bis-(NHC carbenes) alkylene ligand Pt(II) complexes.
- -
-
Page/Page column 3
(2012/12/14)
-
- Chemosensing of nitroaromatics with a new segmented conjugated quaterphenylene polymer
-
A new approach for introducing porosity in fluorescent polymer films to increase sensing performance is presented. A novel segmented conjugated polymer composed of p-quaterphenylene segments tethered by their meta positions along the polymer main chain by 2,2-isopropylene spacers was synthesized. The bent nature of its microstructure generates amorphous morphologies that let analytes diffuse rapidly within the films. Fluorescence quenching studies with polymer films and methanol solutions of nitroaromatics showed high sensitivity, fast response and reversibility of the fluorescence quenching. Thus, half of the maximum quench (Q50%) occurred with nitrobenzene at the micromolar range in less than 1 min in a reversible manner.
- Del Rosso, Pablo G.,Almassio, Marcela F.,Garay, Raúl O.
-
scheme or table
p. 4911 - 4915
(2011/10/08)
-
- Highly enantioselective catalytic alkyl propiolate addition to aliphatic aldehydes
-
A novel H8BINOL-based chiral ligand (S)-3 is found to catalyze the alkyl propiolate addition to aliphatic aldehydes in the presence of ZnEt2 and Ti(OiPr)4 at room temperature with excellent enantioselectivity (89-97% ee).
- Turlington, Mark,DeBerardinis, Albert M.,Pu, Lin
-
supporting information; experimental part
p. 2441 - 2444
(2009/11/30)
-
- Study on the electronic effect on coordinating donors in heptacoordinate trichlorogermanes
-
Trichloro[tris(2,5-dimethoxyphenyl)methyl]germane (1a), trichloro[tris(3-fluoro-6-methoxyphenyl)methyl]germane (1b), and trichloro[tris(2-methoxy-5-trifluoromethylphenyl)methyl]germane (1c) were synthesized. X-ray crystallographic analyses of 1a-c revealed their heptacoordinate geometries around the germanium atoms. The interatomic distances between the oxygen atoms and the central germanium atoms in the crystalline state were not significantly affected by change of functional groups on the benzene rings, while the optimized structures by theoretical calculations and Atoms in Molecules (AIM) analysis indicated linear relationship between the donating ability of functional groups and the O?Ge interatomic interactions.
- Iwanaga, Kohei,Kobayashi, Junji,Kawashima, Takayuki
-
p. 10127 - 10132
(2008/02/13)
-
- Synthesis of dinucleating phenanthroline-based ligands
-
The phenolic bridged dinucleating phenanthroline-pyridine, phenanthroline-phosphine, phenanthroline-alcohol, and phenanthroline-imine ligands have been synthesized from 1,10-phenanthroline via key Stille and Suzuki cross couplings.
- Lam, Fung,Feng, MaoQi,Chan, Kin Shing
-
p. 8377 - 8384
(2007/10/03)
-
- Medium-sized cyclophanes. Part 36. Synthesis and conformational studies of dimethoxymetacyclophanes
-
The synthesis and structure of internally substitutedmetacyclophanes are described.The preparation of tert-butylmetacyclophanes 8 was carried out by using the tert-butyl group as a positional protecting group on the aromatic ring.The reaction of
- Yamato, Takehiko,Matsumoto, Jun-ichi,Sato, Mitsuhiro,Noda, Kozo,Tashiro, Masashi
-
p. 1299 - 1308
(2007/10/02)
-
- Synthesis of Acyclic Dinucleating Phenanthroline-Pyridine and Phenanthroline-Phosphine Ligands
-
The novel phenolic bridged dinucleating phenanthroline-pyridine 10 and phenanthroline-phosphine 15 ligands have been synthesized from 1,10-phenanthroline.
- Lam, Fung,Chan, Kin Shing,Liu, Bang-Ji
-
p. 6261 - 6262
(2007/10/02)
-
- Preparation and Conformational Properties of Tetrahydroxymetacyclophanes
-
The preparation of a novel macrocyclic compound, tetrahydroxymetacyclophane 5 by base-catalysed condensation of 1,3-(2,2'-dihydroxy-5,5'-di-tert-butyldiphenyl)propane 4 with formaldehyde in xylene in 90percent yield is described and its conformat
- Yamato, Takehiko,Saruwatari, Yoshiyuki,Nagayama, Souichiro,Maeda, Kenji,Tashiro, Masashi
-
p. 861 - 862
(2007/10/02)
-
- Medium-Sized Cyclophanes, 20. Synthesis and Conformational Studies of syn- and anti-Dihydroxymetacyclophanes
-
syn- and anti-Dimethoxymetacyclophanes 9 are obtained by pyrolysis of the corresponding anti-sulfones 8, which are prepared by the reaction of 1,n-bisalkanes 6 with Na2S in ethanol under the high dilution conditions,
- Yamato, Takehiko,Matsumoto, Jun-ichi,Tokuhisa, Kiwamu,Kajihara, Masami,Suehiro, Kazuaki,Tashiro, Masashi
-
p. 2443 - 2454
(2007/10/02)
-
- The Synthesis of 7-t-butylisobenzofuran-4,5-dione
-
The title compound has been prepared by a route in which the key step is the decarbonylation and subsequent Alder-Rickert cleavage of the adduct between 8-t-butyl-1,4-dihydro-1,4-epoxynaphthalene-5,6-dione and tetraphenylcyclopentadienone.
- Sims, Colette G.,Wege, Dieter
-
p. 1983 - 1990
(2007/10/02)
-