412919-79-0Relevant articles and documents
The in vivo antinociceptive and μ-opioid receptor activating effects of the combination of N-phenyl-2′,4′-dimethyl-4,5′-bi-1,3-thiazol-2-amines and naloxone
Lin, Shu-Yu,Kuo, Yu-Hsien,Tien, Ya-Wen,Ke, Yi-Yu,Chang, Wan-Ting,Chang, Hsiao-Fu,Ou, Li-Chin,Law, Ping-Yee,Xi, Jing-Hua,Tao, Pao-Luh,Loh, Horace H.,Chao, Yu-Sheng,Shih, Chuan,Chen, Chiung-Tong,Yeh, Shiu-Hwa,Ueng, Shau-Hua
, p. 312 - 323 (2019/02/20)
Morphine is widely used for the treatment of severe pain. This analgesic effect is mediated principally by the activation of μ-opioid receptors (MOR). However, prolonged activation of MOR also results in tolerance, dependence, addiction, constipation, nau
OPIOID RECEPTOR MODULATORS AND USE THEREOF
-
Paragraph 0049; 0059; 0060; 0067; 0071; 0072, (2017/03/21)
Disclosed is an in vitro screening method for identifying an antagonist-to-agonist allosteric modifier of a mu-opioid receptor and an in vivo method for confirming that a test compound is such a modifier of a mu-opioid receptor. Also disclosed is a method