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4-CHLOROMETHYL-7-METHOXY-CHROMEN-2-ONE is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 41295-55-0 Structure
  • Basic information

    1. Product Name: 4-CHLOROMETHYL-7-METHOXY-CHROMEN-2-ONE
    2. Synonyms: 2H-1-Benzopyran-2-one,4-(chloroMethyl)-7-Methoxy-;4-(Chloromethyl)-7-methoxy-2H-chromen-2-one
    3. CAS NO:41295-55-0
    4. Molecular Formula: C11H9ClO3
    5. Molecular Weight: 224.65
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 41295-55-0.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 373°Cat760mmHg
    3. Flash Point: 165.2°C
    4. Appearance: /
    5. Density: 1.309g/cm3
    6. Vapor Pressure: 9.25E-06mmHg at 25°C
    7. Refractive Index: 1.566
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. CAS DataBase Reference: 4-CHLOROMETHYL-7-METHOXY-CHROMEN-2-ONE(CAS DataBase Reference)
    11. NIST Chemistry Reference: 4-CHLOROMETHYL-7-METHOXY-CHROMEN-2-ONE(41295-55-0)
    12. EPA Substance Registry System: 4-CHLOROMETHYL-7-METHOXY-CHROMEN-2-ONE(41295-55-0)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: 20/22
    3. Safety Statements: 36/37
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 41295-55-0(Hazardous Substances Data)

41295-55-0 Usage

Chemical Properties

Off-white solid

Check Digit Verification of cas no

The CAS Registry Mumber 41295-55-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,1,2,9 and 5 respectively; the second part has 2 digits, 5 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 41295-55:
(7*4)+(6*1)+(5*2)+(4*9)+(3*5)+(2*5)+(1*5)=110
110 % 10 = 0
So 41295-55-0 is a valid CAS Registry Number.
InChI:InChI=1/C11H9ClO3/c1-14-8-2-3-9-7(6-12)4-11(13)15-10(9)5-8/h2-5H,6H2,1H3

41295-55-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-(chloromethyl)-7-methoxychromen-2-one

1.2 Other means of identification

Product number -
Other names 4-chloromethyl-7-methoxy-2-oxo-2H-benzopyran

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:41295-55-0 SDS

41295-55-0Relevant articles and documents

Phototriggered release of tetrapeptide AAPV from coumarinyl and pyrenyl cages

Santos, Filipa C.,Soares, Ana M. S.,Gon?alves, M. Sameiro T.,Costa, Susana P. G.

, p. 1077 - 1088 (2017)

Ala–Ala–Pro–Val (AAPV) is a bioactive tetrapeptide that inhibits human neutrophil elastase, an enzyme involved in skin chronic inflammatory diseases like psoriasis. Caged derivatives of this peptide were prepared by proper N- and C-terminal derivatisation through a carbamate or ester linkage, respectively, with two photoactive moieties, namely 7-methoxycoumarin-2-ylmethyl and pyren-2-ylmethyl groups. These groups were chosen to assess the influence of the photosensitive group and the type of linkage in the controlled photo release of the active molecule. The caged peptides were irradiated at selected wavelengths of irradiation (254, 300, and 350?nm), and the photolytic process was monitored by HPLC–UV. The results established the applicability of the tested photoactive groups for the release of AAPV, especially for the derivative bearing the carbamate-linked pyrenylmethyl group, which displayed the shortest irradiation times for the release at the various wavelengths of irradiation (ca. 4?min at 254?nm, 8?min at 300?nm and 46?min at 350?nm).

Coumarin-caged rosamine probes based on a unique intramolecular carbon-carbon Spirocyclization

Lin, Weiying,Long, Lingliang,Tan, Wen,Chen, Bingbing,Yuan, Lin

, p. 3914 - 3917 (2010)

(Figure Presented) Caged fluorophore: We report the first caging strategy for rosamine fluorophores based on a unique intramolecular carbon-carbon spirocyclization. The new class of carbon-carbon spirocyclic caged probes exhibit several sig-nificant advantages over the traditional nitrobenzyl-caged xanthene probes and can be employed for spatially controlled fluorescence imaging of living cells (see graphic).

Design and synthesis of pyrimidine-5-carbonitrile hybrids as COX-2 inhibitors: Anti-inflammatory activity, ulcerogenic liability, histopathological and docking studies

Alfayomy, Abdallah M.,Abdel-Aziz, Salah A.,Marzouk, Adel A.,Shaykoon, Montaser Sh. A.,Narumi, Atsushi,Konno, Hiroyuki,Abou-Seri, Sahar M.,Ragab, Fatma A.F.

, (2021/01/04)

Two new series of 1,3,4-oxadiazole and coumarin derivatives based on pyrimidine-5-carbonitrile scaffold have been synthesized and evaluated for their COX-1/COX-2 inhibitory activity. Compounds 10c, 10e, 10h-j, 14e-f, 14i and 16 were found to be the most potent and selective inhibitors of COX-2 (IC50 0.041–0.081 μM, SI 139.74–321.95). Eight compounds were further investigated for their in vivo anti-inflammatory activity. The most active derivatives 10c, 10j and 14e displayed superior in vivo anti-inflammatory activity (% edema inhibition 39.3–48.3, 1 h; 58.4–60.5, 2 h; 70.8–83.2, 3 h; 78.9–89.5, 4 h) to the reference drug celecoxib (% edema inhibition 38.0, 1 h; 48.8, 2 h; 58.4, 3 h; 65.4, 4 h). These derivatives were also tested for their ulcerogenic liability, compound 10j showed better safety profile with reference to celecoxib while 10c and 14e exhibited mild lesions. Molecular docking studies of 10c, 10j, and 14e in the COX-2 active site revealed similar orientation and binding interactions as selective COX-2 inhibitors with a higher liability to access the selectivity side pocket.

Synthesis of C4-substituted coumarins via Pechmann condensation catalyzed by sulfamic acid. Insights into the reaction mechanism by HRMS analysis

Moraes, Maiara C.,Lenard?o, Eder J.,Barcellos, Thiago

, p. 151 - 163 (2022/01/28)

A series of functionalized C4-substituted coumarins were synthesized by exploring the reaction of activated and non-activated phenols and β-ketoesters under solvent-free conditions in the presence of sulfamic acid as a Br?nsted acid catalyst. Fifteen exam

Design, synthesis and biological evaluation of potential anti-AD hybrids with monoamine oxidase B inhibitory and iron-chelating effects

Guo, Jianan,Mi, Zhisheng,Jiang, Xiaoying,Zhang, Changjun,Guo, Zili,Li, Linzi,Gu, Jinping,Zhou, Tao,Bai, Renren,Xie, Yuanyuan

, (2020/12/29)

A series of active hybrids combining 3-hydroxypyridin-4(1H)-one and coumarin pharmacophores were designed and synthesized as potential agents for the treatment of Alzheimer's disease (AD). All the compounds exhibited excellent iron-chelating activities (p

TRICYCLIC FURAN-SUBSTITUTED PIPERIDINEDIONE COMPOUND

-

Paragraph 0155-0156, (2021/07/17)

Disclosed are a series of tricyclic furan-substituted piperidinedione compounds and an application thereof in preparing a drug for treating a disease related to CRBN protein. In particular, disclosed is a derivative compound represented by formula (I) or a pharmaceutically acceptable salt thereof.

Amino Acids Bearing Aromatic or Heteroaromatic Substituents as a New Class of Ligands for the Lysosomal Sialic Acid Transporter Sialin

Dubois, Lilian,Pietrancosta, Nicolas,Cabaye, Alexandre,Fanget, Isabelle,Debacker, Cécile,Gilormini, Pierre-André,Dansette, Patrick M.,Dairou, Julien,Biot, Christophe,Froissart, Roseline,Goupil-Lamy, Anne,Bertrand, Hugues-Olivier,Acher, Francine C.,Mccort-Tranchepain, Isabelle,Gasnier, Bruno,Anne, Christine

supporting information, p. 8231 - 8249 (2020/09/21)

Sialin, encoded by the SLC17A5 gene, is a lysosomal sialic acid transporter defective in Salla disease, a rare inherited leukodystrophy. It also enables metabolic incorporation of exogenous sialic acids, leading to autoantibodies against N-glycolylneuraminic acid in humans. Here, we identified a novel class of human sialin ligands by virtual screening and structure-activity relationship studies. The ligand scaffold is characterized by an amino acid backbone with a free carboxylate, an N-linked aromatic or heteroaromatic substituent, and a hydrophobic side chain. The most potent compound, 45 (LSP12-3129), inhibited N-acetylneuraminic acid 1 (Neu5Ac) transport in a non-competitive manner with IC50 ≈ 2.5 μM, a value 400-fold lower than the KM for Neu5Ac. In vitro and molecular docking studies attributed the non-competitive character to selective inhibitor binding to the Neu5Ac site in a cytosol-facing conformation. Moreover, compound 45 rescued the trafficking defect of the pathogenic mutant (R39C) causing Salla disease. This new class of cell-permeant inhibitors provides tools to investigate the physiological roles of sialin and help develop pharmacological chaperones for Salla disease.

PHOTOLABILE BARBITURATE COMPOUNDS

-

Page/Page column 29, (2019/08/26)

The present disclosure provides a redox initiator system for initiating polymerization comprising an oxidizing agent, a photolabile reducing agent derived from a barbiturate, and a transition metal complex that participates in a redox cycle. On exposure to actinic radiation, such as UV, the photolabile compound photolyzes, releasing the reducing agent and initiating the redox-initiated polymerization.

Photolabile beta-dicarbonyl compounds

-

Paragraph 0121, (2020/02/18)

The present disclosure provides a redox initiator system for initiating polymerization comprising an oxidizing agent, a photolabile reducing agent, and a transition metal complex that participates in a redox cycle. On exposure to actinic radiation, such as UV, the photolabile compound photolyzes, releasing the reducing agent and initiating the redox-initiated polymerization.

Synthesis of Coumarin-4-Ylmethyl Phosphonic Acids

Kondratyuk,Dluzhevskii,Bondarenko,Brovarets,Frasinyuk

, p. 632 - 637 (2019/08/02)

New coumarin-4-ylmethylphosphonates and coumarin-4-ylmethylphosphonic acids were synthesized and tested for antiviral activity.

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