- Total Synthesis of Phenanthropiperidine Alkaloids by Sequential Alkylation of N,N-Dibenzylaminoacetonitrile
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Two representative members of the phenanthropiperidine alkaloid family, tylophorine (1) and cryptopleurine (2), were synthesized by a bidirectional alkylation strategy employing dibenzylaminoacetonitrile as a substrate. This approach relies on the unprecedented condensation of metallated α-aminonitriles with bromomethylphenanthrenes to provide fully substituted α-aminonitriles, which are subjected to a NaBH4-mediated reductive decyanation process to form homobenzylic amines. From these intermediates, a terminal leaving group was introduced by simple chemical manipulation, and its displacement by a free primary amine under two favorable cyclization processes led to the formation of the future E-ring of both alkaloids in high yields. Finally, a late Pictet-Spengler cyclization ensured the formation of a D-ring for the alkaloids 1 and 2.
- Bouvry, Christelle,Cupif, Jean-Fran?ois,Franzetti, Milène,Hurvois, Jean-Pierre
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p. 6037 - 6051
(2021/12/10)
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- Donepezil–melatonin hybrids as butyrylcholinesterase inhibitors: Improving binding affinity through varying mode of linking fragments
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Hybrid inhibitors of acetyl- and butyrylcholinesterase are compounds that combine structural motifs of two different classical inhibitors, leading to a dual binding ligand. A rapidly growing collection of those compounds involves a wide diversity of structural motifs, but the way of linking two active fragments and its impact on the affinity toward cholinesterases usually remains beyond the extent of investigation. We present hereby a detailed analysis of this aspect using melatonin–donepezil hybrids. A new series of compounds, in which two fragments are connected using a carbamate linker, exhibits excellent activity and selectivity toward butyrylcholinesterase.
- ?ozińska, Iwona,?wierczyńska, Aleksandra,Mol?da, Zuzanna,Hartman, Alwin M.,Hirsch, Anna K. H.,Czarnocki, Zbigniew
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- Selexipag intermediates and method for preparing selexipag
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The invention belongs to the field of chemical preparation, and relates to selexipag intermediates and a method for preparing selexipag. The selexipag intermediates are a compound SLP-4, a compound SLP-7, a compound SLP-8 and a compound SLP-10. The selexipag intermediates and the method have the advantages that the method for preparing the selexipag includes reasonable routes and is low in cost and operative difficulty and little in environmental pollution, raw materials are easily available, accordingly, requirements of large-scale industrial production can be met by the method, and the like.
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Paragraph 0063; 0084; 0085; 0086; 0087; 0088
(2017/08/27)
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- POLYMERIZABLE COMPOUND AND OPTICAL ANISOTROPIC BODY
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PROBLEM TO BE SOLVED: To provide a polymerizable compound having high storage stability without causing precipitation of crystals or the like when added to a polymerizable composition and large refractive index anisotropy and to provide a polymerizable composition which hardly causes haze when polymerized by attaching a resin mold to a polymerizable composition containing the polymerizable compound. SOLUTION: There are provided: a compound represented by the formula (I), for example, a compound represented by the formula (I-106); a composition containing the compound; a polymer obtained by polymerizing the compound; and an optical anisotropic body using the polymer. COPYRIGHT: (C)2016,JPOandINPIT
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Paragraph 0156-0158
(2018/09/30)
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- Studies towards the synthesis of crotogoudin
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An effective synthesis of the tricyclic core structure of the new diterpene crotogoudin was achieved. The synthesis features an intermolecular domino Michael reaction to construct a bicyclo[2.2.2]octane motif and an aldol condensation to close ring B. Stork reductive alkylation with allyl bromide proceeded from the β side, resulting in the wrong stereochemistry at C-10. Georg Thieme Verlag Stuttgart - New York.
- Ushakov, Dmitry B.,Maier, Martin E.
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supporting information
p. 705 - 708
(2013/05/09)
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- Mild and efficient chemoselective tetrahydropyranylation of alcohols using bronsted acidic ionic liquid as catalyst under solvent-free conditions
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A straightforward and efficient method for preparation of morpholinium bisulfate ([mroH]HSO4) as a novel acidic ionic liquid is reported. The application of this efficient and inexpensive acidic ionic liquid catalyst for tetrahydropyranylation of alcohols under mild and solvent-free conditions at room was investigated.
- Hajipour, Abdol R.,Nasresfahani, Zahra
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experimental part
p. 1995 - 2006
(2012/06/04)
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- Tetrahydropyranylation of alcohols under solvent-free conditions
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A green, efficient, and large-scale method for tetrahydropyranylation of alcohols in the presence of a catalytic amount of pyridinium chloride at room temperature under solvent-free conditions is reported. Copyright Taylor & Francis Group, LLC.
- Hajipour, Abdol R.,Kargosha, Majid,Ruoho, Arnold E.
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experimental part
p. 1084 - 1091
(2009/09/08)
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- Synthesis of new analogs of benzotriazole, benzimidazole and phthalimide-potential inhibitors of human protein kinase CK2
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New derivatives of 4,5,6,7-tetrabromo-1H-1,2,3-benzotriazole (TBBt), 4,5,6,7-tetrabromo-1H-benzimidazole (TBBi), and N-substituted tetrabromophthalimides were synthesized and their effect on the activity of human protein kinase CK2 was examined. The most active were derivatives with N-hydroxypropyl substituents (IC50 in 0.32-0.54 μM range) whereas derivatives of phthalimide were almost ineffective.
- Najda-Bernatowicz, Andzelika,Lebska, Maja,Orzeszko, Andrzej,Kopanska, Katarzyna,Krzywinska, Ewa,Muszynska, Grazyna,Bretner, Maria
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experimental part
p. 1573 - 1578
(2009/08/08)
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- Design, synthesis, and evaluation of new chemosensitizers in multi-drug-resistant Plasmodium falciparum
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A series of new chemosensitizers (modulators) against chloroquine-resistant Plasmodium falciparum were designed and synthesized in an attempt to fabricate modulators with enhancing drug-resistant reversing efficacy and minimal side effects. Four aromatic amine ring systems phenothiazine, iminodibenzyl, iminostilbene, and diphenylamine-were examined. Various tertiary amino groups including either noncyclic or cyclic aliphatic amines were introduced to explore the steric tolerance at the end of the side chain. The new compounds showed better drug-resistant reversing activity in chloroquine-resistant than in mefloquine-resistant cell lines and were generally more effective against chloroquine-resistant P. falciparum isolates from Southeast Asian (W2 and TM91C235) than those from South America (PC49 and RCS). Structure-activity relationship studies revealed that elongation of the alkyl side chain of the molecule retained the chemosensitizing activity, and analogues with four-carbon side chains showed superior activity. Furthermore, new modulators with phenothiazine ring exhibited the best chemosensitizing activity among the four different ring systems examined. Terminal amino function has limited steric tolerance as evidenced by the dramatic lose of the modulating activity, when the size of substituent at the amino group increases. The best new modulator synthesized in this study possesses all three optimized structural features, which consist of a phenothiazine ring and a pyrrolidinyl group joined by a four-carbon alkyl bridge. The fractional inhibitory concentration (FIC) index of the best compound is 0.21, which is superior to that of verapamil (0.51), one of the best-known multi-drug-resistant reversing agents. Some of the analogues displayed moderate intrinsic in vitro antimalarial activity against a W-2 clone of P. falciparum.
- Guan, Jian,Kyle, Dennis E.,Gerena, Lucia,Zhang, Quan,Milhous, Wilbur K.,Lin, Ai J.
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p. 2741 - 2748
(2007/10/03)
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- Progress toward the development of a safe and effective agent for treating reentrant cardiac arrhythmias: Synthesis and evaluation of ibutilide analogues with enhanced metabolic stability and diminished proarrhythmic potential
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A series of ibutilide analogues with fluorine substituents on the heptyl side chain was prepared and evaluated for class III antiarrhythmic activity, metabolic stability, and proarrhythmic potential. It was found that fluorine substituents stabilized the side chain to metabolic oxidation. Many of the compounds also retained the ability to increase the refractoriness of cardiac tissue at both slow and fast pacing rates. The potential for producing polymorphic ventricular tachycardia in the rabbit model was dependent on the chirality of the benzylic carbon. The S-enantiomers generally had less proarrhythmic activity than the corresponding racemates. One compound from this series (45E, trecetilide fumarate) had excellent antiarrhythmic activity and metabolic stability and was devoid of proarrhythmic activity in the rabbit model. It was chosen for further development.
- Hester,Gibson,Buchanan,Cimini,Clark,Emmert,Glavanovich,Imbordino,LeMay,McMillan,Perricone,Squires,Walters
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p. 1099 - 1115
(2007/10/03)
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- (Chloro-phenylthio-methylene)dimethylammonium chloride (CPMA) an efficient reagent for selective chlorination and bromination of primary alcohols
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(Chloro-phenylthio-methylene)dimethylammonium chloride reacts smoothly with a variety of alcohols, to afford the corresponding alkyl chloride in good yields. In the presence of tetrabuthylammonium bromide the corresponding bromide is obtained. Selective halogenation of primary hydroxyl groups in the presence of an unprotected secondary one is described. The mild reaction conditions involved are compatible with the major alcohol protecting groups as well as with acid sensitive functions like epoxides. (C) 2000 Elsevier Science Ltd.
- Gomez,Gellibert,Wagner,Mioskowski
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p. 6049 - 6052
(2007/10/03)
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- Synthesis of acyclic adenine 8,N-anhydronucleosides
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9-(4-Hydroxybutyl)adenine (10) was obtained by reaction of adenine with 4-[(2-tetrahydropyran-2-yl)oxy]butyl chloride (7) in the presence of DBU. 8-Bromo-9-(4-hydroxybutyl)adenine (13) was prepared by bromination of 10 or by alkylation of 8-bromoadenine (11) with 4-bromoethyl acetate followed by methanolysis. Tosylation of compound 13 afforded the 4-tosyloxy derivative 15 which gave on heating with methylamine or cyclopropylamine 6-methyl-(17a) or 6-cyclopropyl-7,8,9,10-tetrahydro-6H-[1,3]diazepino[1,2-e]purin-4-amine (17b), while the reaction with hydrazine afforded 7,8,9,10-tetrahydro-6H-[1,3]diazepino-[1,2-e]purine-4,6-diamine (17d). Treatment of compound 13 with thionyl chloride gave 9-(4-chlorobutyl)-8-chloroadenine (18) as the main product which was transformed to 17b, 6-propyl-7,8,9,10-tetrahydro-6H-[1,3]diazepino[1,2-e]purin-4-amine (17c) or 7,8,9,10-tetrahydro-6H-[1,3]diazepino[1,2-e]purin-4-amine (17e) by reaction with cyclopropylamine, propylamine or ammonia, respectively. Compound 17e was quite stable both in acid and alkaline solutions, at room temperature or at 90 °C. Compound 13 was converted to 9-(4-hydroxybutyl)-8-methylaminoadenine (19) by reaction with methylamine. Compound 19 failed to undergo intramolecular cyclization to diazepine 17a on treatment with diphenyl carbonate, bis(4-nitrophenyl) carbonate or 1,1′-carbonyldiimidazole.
- Meszarosova, Katerina,Holy, Antonin,Masojidkova, Milena
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p. 1109 - 1125
(2007/10/03)
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- Acyclic phenylalkanediols as substrates for the study of enzyme recognition: Synthesis of substrates and enzymatic resolution via hydrolysis and transesterification
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Different racemic or prochiral phenyl alkane (1,n)-diols were synthesized, and their resolution was carried out by two different strategies: enzymatic transesterification with vinyl acetate, or enzymatic hydrolysis of their corresponding diacetates, in both cases catalysed by porcine pancreatic lipase (PPL). The absolute configuration of the optically enriched reaction products was determined by formation of Mosher's esters or by the use of the Benzene Sector and Benzene Chirality Rules as obtained from the Circular Dichroism spectra.
- Rumbero, Angel,Borreguero, Isabel,Sinisterra, Jose V.,Alcantara, Andres R.
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p. 14947 - 14960
(2007/10/03)
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- Intramolecularly alkylated Costa complexes: New models for coenzyme B12 with a cobalt-to-ligand carbon bridge
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The synthesis of Costa-type B12 models 1 with a carbon bridge between the equatorial ligand and cobalt has been accomplished by condensation of butanedione monoxime and 2-(ω-functionalized)alkyl-1,3-diaminopropanes 8 followed by complexation with Co(II), introduction of a leaving group and intramolecular alkylation via Co(I) intermediates. The solution structure of intramolecularly alkylated Costa complexes with a bridge of two (1a) or of three (1b) methylene groups was investigated by NMR spectroscopy and compared with that of propyl(iodo) Costa complex 13.
- Van Arkel, Bert,Van Der Baan, Juul L.,Balt, Sijbe,Bickelhaupt, Friedrich,De Bolster, Martinus W. G.,Klumpp, Gerhard W.
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p. 4161 - 4172
(2007/10/02)
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- Dicyanoketene ethylene acetal as a mild and efficient catalyst for tetrahydropyranylation of alcohols
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Alcohols can react with 3,4-dihydro-2H-pyran in the presence of a catalytic amount of dicyanoketene ethylene acetal under neutral conditions to afford the corresponding tetrahydropyranyl ethers in good yields.
- Miura,Masaki
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p. 1981 - 1987
(2007/10/02)
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- The synthesis of binucleating polyaza macrocyclic and macrobicyclic ligands and the dioxygen affinities of their cobalt complexes
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The synthesis of a new macrobicyclic (cryptand) ligand 1,4,9,12,19,20,25,30-octaazabicyclo(10.10.10)dotriacontane, C4BISTREN and improved syntheses of the ligands 7,9,30,trioxa-1,4,10,13,16,22,-27,33-octaazabicyclo(11.11.11)pentatria contane, OBISTREN and 1,13-dioxa-4,7,10,16,19,22-hexaazacyclotetracosane, OBISDIEN. The Co(II) complexes of these ligands are oxygen carriers. Among the six macrocyclic and six macrobicyclic ligands that are considered in this paper, the binuclear cobalt(II) complexes of OBISTREN and OBISDIEN form the most stable dioxygen complexes.
- Chen, Dian,Motekaitis, Ramunas J.,Murase,Martell, Arthur E.
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- SYNTHESE ET ETUDE ELECTROCHIMIQUE D'ALCOOLS ET D'ESTERS DERIVES DE 3-ALKYL THIOPHENES
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Starting from 3-bromothiophene, ω-(3-thienyl)alkan-1-ols and ω-(3-thienyl)alkyl esters are obtained.Electrochemical characteristics and polymerization are described and discussed.Key words: ω-(3-thienyl)alkanols and ω-(3-thienyl)alkyl esters, electrochemical polymerization.
- Blanchetiere, D.,Noyere, C.,Catel, J.,Andrieu, C. G.,Ebel, M.
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- Synthesis of the Alkaloid Homaline in (+/-) and Natural (S,S)-(-) Forms, using Amination and Transamidative Ring Expansion in Liquid Ammonia
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Synthesis of the alkaloid homaline in (+/-) and natural (S,S)-(-) forms is reported.Linking of 2-azacyclooctanone units either directly or successively using 1,4-dihalogenobutanes or 1,4-dihalogenobut-2-ynes is examined. (+/-)-5-Methyl-4-phenyl-1,5-diazacyclooctan-2-one is first made by a 2,2'-dithiodipyridine/triphenylphosphine-mediated cyclisation, and then by amination and transamidative ring expansion from N-(3-chloropropyl)-4-phenylazetidin-2-one in liquid ammonia, followed by N-methylation.Coupling through a 1,4-dihalogenobutane of either the N-methylated azalactam, or the unmethylated azalactam followed by methylation, gave homaline in (+/-) and meso forms. (R)-(-)-Phenylglycine was converted via (S)-β-phenyl-β-alanine into an (S)-β-lactam which was then alkylated with 1-bromo-3-chloropropane, and aminated and ring expanded in liquid ammonia.Coupling of the homochiral azalactam (2 mol) so formed with 1,4-dibromobutane, followed by N-methylation, gave (S,S)-(-)-homaline identical with the natural material.
- Crombie, Leslie,Haigh, David,Jones, Raymond C. F.,Mat-Zin, Ab. Rasid
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p. 2047 - 2054
(2007/10/02)
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- Pheromone Synthesis, CXXXI Synthesis of the Four Stereoisomers of 6,10,13-Trimethyl-1-tetradecanol, Aggregation Pheromone of Predatory Stink Bug, Stiretrus anchorago
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The synthesis of the four stereoisomers of 6,10,13-trimethyl-1-tetradecanol (1a), the male-produced aggregation pheromone of the predatory stink bug Stiretrus anchorago, was achieved by starting from (R)-citronellol (2a), methyl (R)- or (S)-3-hydroxy-2-methylpropanoate (10) and 4-chloro-1-butanol (12a). - Key Words: Grignard coupling / Phenyl sulfone, alkylation of / Pheromone, enantiomerically pure / Stiretrus anchorago / 1-Tetradecanol, 6,10,13-trimethyl- / Sulfones
- Mori, Kenji,Wu, Jiang
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p. 783 - 788
(2007/10/02)
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- Macrocyclic Polyamines -N3 and -N4: Synthesis and Study of their ATP Complexation by 31P Nuclear Magnetic Resonance Spectroscopy
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The macrocyclic polyamines -N3, compound 1, and -N4, compound 2, possessing a hydroxymethyl side-chain have been synthesized.The macrocyclisation was achieved by condensation of lysine ditosate 3b with appropriate components 5 and 6 in the presence of CsCO3 to obtain 7 and 8 in 33 and 37percent yield, respectively.The complexation of polyamines 1 and 2 with ATP was studied by 31P NMR spectroscopy, which indicated a specific recognition of γ-phosphorus of ATP (NMe4 salt) by the polyamines.The binding constant estimates indicated that ATP binds compound 2 ca. 35-times stronger than it does compound 1.The binding curves indicated a definite 1:1 stoicheiometry for 2:ATP complex, and not so well defined stoicheiometry for 1:ATP binding.The mononucleotides, AMP and cAMP, and dinucleotide TpT did not show significant complexation with either compound 1 or 2.The binding of ATP by macrocyclic polyamines 1 and 2 and the presence of a hydroxymethyl side-chain to link with a nucleophile may aid rational design of chemical nucleases.
- Prakash, T. P.,Pattuparanbil, Rajamohanan,Ganesh, Wagappa K.
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p. 1273 - 1278
(2007/10/02)
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- Towards the total synthesis of clerodin. Part I
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A highly stereo- and enantioselective approach to clerodin 1, an insect antifeedant, is described. The key step involved the stereospecific formation of the C9-C11 bond, at an early stage of the synthesis, using a Claisen rearrangement.
- Bouchard,Renard,Lallemand
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p. 5953 - 5956
(2007/10/02)
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- Substituted tetrahydropyridines as central nervous system agents
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Substituted tetrahydropyridines and derivatives thereof are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful as central nervous system agents and are particularly useful as dopaminergic, antipsychotic, and antihypertensive agents as well as for treating hyperprolactinaemia-related conditions and central nervous system disorders.
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- Use of 2-phenylsulphonyl cyclic ethers in the preparation of tetrahydropyran and tetrahydrofuran acetals and in some glycosidation reactions
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2-Phenylsulphonyl cyclic ethers undergo facile displacement of the sulphonyl group by alcohols, in the presence of magnesium bromide etherate and sodium bicarbonate in tetrahydrofuran, to give goodyields of the corresponding acetals.
- Brown, Dearg S.,Ley, Steven V.,Vile, Sadie,Thompson, Mervyn
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p. 1329 - 1342
(2007/10/02)
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- Asymmetric synthesis of a pheromone for Andrena haemorrhoa F from a chiral nitro alcohol obtained by the yeast reduction of a nitro ketone
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The α-position to the nitro group in 4-nitro-2-butanol or 5-nitro-2-pentanol was acylated under DBU-catalysis after the hydroxy group was protected by a t-butyl dimethylsilyl group. The present method has been applied to the asymmetric stereoselective synthesis of a pheromone for Andrena haemorrhoa F, which has an interesting spiroacetal strucure.
- Nakamura, Kaoru,Kitayama, Takashi,Inoue, Yoshihiko,Ohno, Atsuyoshi
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p. 7471 - 7481
(2007/10/02)
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- PREPARATION OF CYCLIC ETHER ACETALS FROM 2-BENZENESULPHONYL DERIVATIVES: A NEW MILD GLYCOSIDATION PROCEDURE
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Several alcohols ranging from hindered to those containing chemically sensitive groups react with 2-benzenesulphonyl cyclic ethers in the presence of magnesium bromide etherate and sodium bicarbonate to give good yields of the corresponding acetals.
- Brown, Dearg S.,Ley, Steven V.,Vile, Sadie
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p. 4873 - 4876
(2007/10/02)
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- Synthesis of Various New Nitroxide Free Radical Fatty Acids
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A generally applicable method is presented for the synthesis of various new nitroxide fatty acid isomers in which the fatty acid chains are attached at different positions of the pyrrolidin-1-oxyl ring.These isomers can be obtained by Michael addition of a nitroalkane to an α,β-unsaturated ketone to give a γ-nitro ketone, followed by ring closure with zinc and ammonium chloride to give a 1-pyrroline N-oxide which then reacts with Grignard reagents to give a pyrrolidin-1-oxyl free radical compound, which undergoes phase transfer oxidation of its terminal unsaturated bond.
- Hideg, Kalman,Lex, Laszlo
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p. 1431 - 1438
(2007/10/02)
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- Synthese de methyl-8 dehydro-1,2 pyrrolizidines et de methyl-9 dehydro-1,2 indolizidines
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A synthetic route to the title compounds is described.It is based on the intramolecular cyclisation of hydroxy-Δ-3-pyrrolines 9, which are prepared in two steps from 2H-pyrroles 4.The stereoselectivity of the sequence can be controlled by changing the order of these two steps.
- Abbas, S. A.,Laurent, A.,Mison, P.,Pellissier, N.
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p. 288 - 296
(2007/10/02)
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- Pheromone Synthesis, LXIV. - Synthesis of the Enantiomers of 2-Methyl-1,7-dioxaspirododecane, a Component of the Volatile Secretion from the Mandibular Glands of Andrena haemorrhoa F.
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The syntheses of the title compounds (2R,6S)-1 and (2S,6R)-1 from (R)- and (S)-β-hydroxybutyrate 3 are described.The formation of the spiroacetal 1 from (R)-9 proceeded stereoselectively to give only (2R,6S)-1.Similarly (S)-9 yielded (2S,6R)-1.
- Mori, Kenji,Katsurada, Manabu
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p. 157 - 161
(2007/10/02)
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- INSECT SEX PHEROMONES. STEREOSELECTIVE SYNTHESIS OF SEVERAL (Z)- AND (E)-ALKEN-1-OLS, THEIR ACETATES, AND OF (9Z,12E)-9,12-TETRADECADIEN-1-YL ACETATE
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Several female sex pheromone components produced by moths belonging to the order of Lepidoptera, and potential attractants of Dacus oleae (Diptera:Tripetidae) have been synthesized in high chemical and stereoisomeric purity by improved acetylenic routes involving alkylation of lithium 1-alkyn-1-ides in HMPT, followed by (Z) and (E) highly stereoselective reduction of the derived internal alkynes.Particular care has been paid to optimize the parameters of the reactions used and to evaluate the chemical and isomeric purity of the reaction products.The compounds synthesized include (Z)- and (E)-5-nonen-1-ol, (Z)- and (E)-7-dodecen-1-yl acetate, (Z)- and (E)-7-teradecen-1-yl acetate, (Z)- and (E)-7-nonen-1-ol, (Z)- and (E)-9-tetradecen-1-yl acetate, (Z)- and (E)-10-tetradecen-1-yl acetate, (Z)- and (E)-11-tetradecen-1-yl acetate.Pure (Z)-6-nonen-1-ol, which is an attractant of olive fruit fly, D. oleae, and very probably, a constituent of the sex pheromone of females of this insect, has been prepared by a rather efficient copper-catalyzed reaction between (Z)-3-hexen-1-ylmagnesium bromide and oxetane. (9Z,12E)-9,12-Tetradecadien-1-yl acetate, which is the pheromone of Anagasta kuenniella, Ephestia elutella, Cadra figulella, Spodoptera exigua, S. litura, and a component of the sex pheromones of several other Lepidoptera, has been conveniently prepared by using the copper-catalyzed coupling reaction between (E)-1-chloro-2-butene and 10-tetrahydropyranyloxy-1-decenylmagnesium bromide, followed by acetylation and Z-stereoselective reduction of the derived 1,4-enyne.All syntheses have been conducted on a scale to yield less than 50 mmol of the pure sex pheromone components, but seem adaptable for much larger quantities.
- Rossi, Renzo,Carpita, Adriano,Gaudenzi, Loretta,Quirici, Maria Grazia
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p. 237 - 246
(2007/10/02)
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- SYNTHESIS OF HIGHER ACETYLENIC ALCOHOLS
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The alkylation of 1-alkynes in various solvents was investigated, and the optimum conditions for the production of acetylenic alcohols were obtained.
- Kovalev, B. G.,Matveeva, E. D.,Stan, V. V.,Vovk, G. A.,Yudin, L. G.,Kost, A. N.
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p. 1728 - 1733
(2007/10/02)
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- Derivatives of 9-oxo-13-trans-prostenoic acid esters
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This disclosure describes homologues, analogues, congeners, and derivatives of 9-oxo-13-trans-prostenoic acid and of 9-hydroxy-13-trans-prostenoic acid, having antimicrobial activity and prostaglandin-like hypotensive activity.
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- Derivatives of 9-oxo-13-trans-prostenoic acid amides
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This disclosure described homologues, analogues, congeners, and derivatives of 9-oxo-13-trans-prostenamide and of 9-hydroxy-13-trans-prostenamide, having antimicrobial activity and prostaglandin-like hypotensive activity.
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