- Nickel-Catalyzed Aminofluoroalkylation of Alkenes: Access to Difluoroalkylated N-Containing Heterocyclic Compounds
-
A nickel-catalyzed aminofluoroalkylative cyclization of unactive alkenes with iododifluoromethyl ketones was developed to construct versatile difluoroalkylated Nitrogen-containing heterocycles including aziridines, pyrrolidines and piperidines in moderate to high yields. This method features a broad substrate scope and has been demonstrated on gram scale.
- Fu, Xiaoyi,Zhang, Tianyu,Wu, Jingjing,Sun, Yijie,Wu, Fanhong
-
supporting information
(2021/12/03)
-
- Copper-Catalyzed Three-Component Reactions of 2-Iodo-2,2-difluoroacetophenones, Alkynes, and Trimethylsilyl Cyanide
-
A Cu(I)-catalyzed three-component reaction of 2-iodo-2,2-difluoroacetophenones, alkynes, and TMSCN is described. The reaction provided a facile method for the synthesis of difluoroacyl-substituted nitriles, which might be served as potentially useful fluo
- Wu, Pingjie,Zheng, Cheng,Wang, Xia,Wu, Jingjing,Wu, Fanhong
-
supporting information
p. 1420 - 1423
(2021/02/01)
-
- Preparation method of gamma-bromine-beta, gamma-alkenyl fluoroketone derivatives
-
The invention relates to a preparation method of gamma-bromine-beta, gamma-alkenyl fluoroketone derivatives, which comprises the following steps: dissolving a compound represented by formula (IV) andcorresponding alkyne in acetone, adding bis (triphenylph
- -
-
Paragraph 0026-0028
(2021/01/30)
-
- A accompanies two fluorine substituted tetrahydronaphthalene ketone compound and its preparation method
-
The invention provides a accompanies two fluorine substituted tetrahydronaphthalene ketone compound and its preparation method. The accompanies two fluorine substituted tetrahydronaphthalene ketone compound, characterized in that its structure such as for
- -
-
Paragraph 0034; 0036; 0042; 0044; 0049; 0051
(2019/07/04)
-
- Nickel-Catalyzed Coupling Reaction of α-Bromo-α-fluoroketones with Arylboronic Acids toward the Synthesis of α-Fluoroketones
-
A nickel-catalyzed coupling reaction of α-bromo-α-fluoroketones with arylboronic acids was reported, which provides an efficient pathway to access 2-fluoro-1,2-diarylethanones in high yields. We also disclosed the synthesis of the monofluorination agents
- Liang, Junqing,Han, Jie,Wu, Jingjing,Wu, Pingjie,Hu, Jian,Hu, Feng,Wu, Fanhong
-
supporting information
p. 6844 - 6849
(2019/09/07)
-
- Beta-iododifluoroacetone derivative and preparation method thereof
-
The invention relates to a beta-iododifluoroacetone derivative and a preparation method thereof. The preparation method comprises the following steps: dissolving an iododifluoroketone compound raw material and an olefin raw material in a solvent, then add
- -
-
Paragraph 0035; 0036; 0038; 0039
(2020/01/12)
-
- Palladium-Catalyzed Benzodifluoroalkylation of Alkynes: A Route to Fluorine-Containing 1,1-Diarylethylenes
-
A palladium(0)-catalyzed three-component reaction of 2-iodo-2,2-difluoroacetophenones, alkynes and arylboronic acids is introduced for the synthesis of 1-benzoyldifluoromethyl-2,2-diphenylethylenes in good yields and with excellent stereoselectivity. The
- Liang, Junqing,Huang, Guozhi,Peng, Peng,Zhang, Tianyu,Wu, Jingjing,Wu, Fanhong
-
supporting information
p. 2221 - 2227
(2018/04/17)
-
- Detrifluoroacetylation Reaction of Trifluoromethyl-β-diketones: Facile Method for the Synthesis of Succinimide Derivatives and 1,4-Diketones
-
Currently, a great deal of research efforts are focused on C–C bond activation for development of novel synthetic methodology. In this paper, a detrifluoroacetylation of trifluoromethyl-β-diketones is described, which allows for the synthesis of succinimides and 1,4-diketones through cascade Michael addition/retro-Claisen reaction and nucleophilic substitution/retro-Claisen reaction. The readily available trifluoromethyl-β-diketones, wide substrate scope, and mild conditions make this method very practical.
- Wang, Li-Hua,Zhao, Jing
-
supporting information
p. 4345 - 4348
(2018/08/31)
-
- Synthesis of α,α-difluorobenzoyl oxygen heterocycles via the radical reaction of 2-iodo-2,2-difluoroacetophenones with unsaturated acids or unsaturated alcohols
-
A convenient and facile method for the direct synthesis of α,α-difluorobenzoyl lactones or cyclic ethers via the radical cyclization reaction of 2-iodo-2,2-difluoroacetophenone with unsaturated acids or alcohols was reported.
- Chen, Heng,Wang, Jiexiong,Wu, Jingjing,Kuang, Yujia,Wu, Fanhong
-
-
- Palladium-catalyzed direct mono-α-arylation of α-fluoroketones with aryl halides or phenyl triflate
-
A palladium catalyzed Negishi-type α-arylation of α-fluoroketones with electron-rich and electron-deficient aryl halides or phenyl triflate has been developed. This direct mono-α-arylation method generate a variety of ternary α-aryl-α-monofluoroketones easily in good to excellent yields using XPhos as ligand and Cs2CO3as mild base.
- Zhou, Jun,Fang, Xiang,Shao, Tongle,Yang, Xueyan,Wu, Fanhong
-
supporting information
p. 54 - 62
(2016/10/05)
-
- Synthesis of difluoroalkyl-γ-butyrolactones from iododifluoromethyl ketones and 4-pentenoic acids
-
A convenient and efficient approach for difluoroalkyl-containing γ-butyrolactones via the radical addition reaction of iododifluoromethyl ketones with 4-pentenoic acids initiated by AIBN in CH3CN at 60 °C was reported. Various difluoroalkyl-containing δ-valerolactones were also synthesized under this reaction conditions.
- Wang, Jie-Xiong,Wu, Jing-Jing,Chen, Heng,Zhang, Shao-Wu,Wu, Fan-Hong
-
p. 1381 - 1384
(2015/10/28)
-
- Organocatalytic asymmetric michael addition/carbon-carbon bond cleavage of trifluoromethyl α-fluorinated gem-diols to nitroolefins
-
A new organocatalytic asymmetric Michael addition reaction by cleavage of carbon-carbon bonds through a mild release of trifluoroacetate has been developed. The reported method generates the decarboxylated γ-nitro- α-fluorocarbonyl products with excellent enantioselectivies (up to 98% ee) and good diastereoselectivies (up to 20:1 dr). Copyright
- Saidalimu, Ibrayim,Fang, Xiang,Lv, Wenwen,Yang, Xueyan,He, Xiaopeng,Zhang, Jingyuan,Wu, Fanhong
-
supporting information
p. 857 - 863
(2013/05/08)
-
- Highly enantioselective construction of 3-hydroxy oxindoles through a decarboxylative aldol addition of trifluoromethyl α-fluorinated gem-diols to n-benzyl isatins
-
An organocatalytic asymmetric direct aldol addition reaction that involves cleavage of a carbon-carbon bond through the release of trifluoroacetate was developed. The protocol is wide in scope, generating the desired oxindoles of biological interest in nearly quantitative yields (up to 99 %) with excellent enantioselectivities (up to 98 % ee) and diastereoselectivities (up to 99:1 d.r.). Copyright
- Saidalimu, Ibrayim,Fang, Xiang,He, Xiao-Peng,Liang, Jing,Yang, Xueyan,Wu, Fanhong
-
supporting information
p. 5566 - 5570
(2013/06/27)
-