41463-86-9Relevant academic research and scientific papers
Nickel-Catalyzed Aminofluoroalkylation of Alkenes: Access to Difluoroalkylated N-Containing Heterocyclic Compounds
Fu, Xiaoyi,Zhang, Tianyu,Wu, Jingjing,Sun, Yijie,Wu, Fanhong
supporting information, (2021/12/03)
A nickel-catalyzed aminofluoroalkylative cyclization of unactive alkenes with iododifluoromethyl ketones was developed to construct versatile difluoroalkylated Nitrogen-containing heterocycles including aziridines, pyrrolidines and piperidines in moderate to high yields. This method features a broad substrate scope and has been demonstrated on gram scale.
Copper-Catalyzed Three-Component Reactions of 2-Iodo-2,2-difluoroacetophenones, Alkynes, and Trimethylsilyl Cyanide
Wu, Pingjie,Zheng, Cheng,Wang, Xia,Wu, Jingjing,Wu, Fanhong
supporting information, p. 1420 - 1423 (2021/02/01)
A Cu(I)-catalyzed three-component reaction of 2-iodo-2,2-difluoroacetophenones, alkynes, and TMSCN is described. The reaction provided a facile method for the synthesis of difluoroacyl-substituted nitriles, which might be served as potentially useful fluo
Preparation method of gamma-bromine-beta, gamma-alkenyl fluoroketone derivatives
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Paragraph 0026-0028, (2021/01/30)
The invention relates to a preparation method of gamma-bromine-beta, gamma-alkenyl fluoroketone derivatives, which comprises the following steps: dissolving a compound represented by formula (IV) andcorresponding alkyne in acetone, adding bis (triphenylph
A accompanies two fluorine substituted tetrahydronaphthalene ketone compound and its preparation method
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Paragraph 0034; 0036; 0042; 0044; 0049; 0051, (2019/07/04)
The invention provides a accompanies two fluorine substituted tetrahydronaphthalene ketone compound and its preparation method. The accompanies two fluorine substituted tetrahydronaphthalene ketone compound, characterized in that its structure such as for
Nickel-Catalyzed Coupling Reaction of α-Bromo-α-fluoroketones with Arylboronic Acids toward the Synthesis of α-Fluoroketones
Liang, Junqing,Han, Jie,Wu, Jingjing,Wu, Pingjie,Hu, Jian,Hu, Feng,Wu, Fanhong
supporting information, p. 6844 - 6849 (2019/09/07)
A nickel-catalyzed coupling reaction of α-bromo-α-fluoroketones with arylboronic acids was reported, which provides an efficient pathway to access 2-fluoro-1,2-diarylethanones in high yields. We also disclosed the synthesis of the monofluorination agents
Beta-iododifluoroacetone derivative and preparation method thereof
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Paragraph 0035; 0036; 0038; 0039, (2020/01/12)
The invention relates to a beta-iododifluoroacetone derivative and a preparation method thereof. The preparation method comprises the following steps: dissolving an iododifluoroketone compound raw material and an olefin raw material in a solvent, then add
Palladium-Catalyzed Benzodifluoroalkylation of Alkynes: A Route to Fluorine-Containing 1,1-Diarylethylenes
Liang, Junqing,Huang, Guozhi,Peng, Peng,Zhang, Tianyu,Wu, Jingjing,Wu, Fanhong
supporting information, p. 2221 - 2227 (2018/04/17)
A palladium(0)-catalyzed three-component reaction of 2-iodo-2,2-difluoroacetophenones, alkynes and arylboronic acids is introduced for the synthesis of 1-benzoyldifluoromethyl-2,2-diphenylethylenes in good yields and with excellent stereoselectivity. The
Detrifluoroacetylation Reaction of Trifluoromethyl-β-diketones: Facile Method for the Synthesis of Succinimide Derivatives and 1,4-Diketones
Wang, Li-Hua,Zhao, Jing
supporting information, p. 4345 - 4348 (2018/08/31)
Currently, a great deal of research efforts are focused on C–C bond activation for development of novel synthetic methodology. In this paper, a detrifluoroacetylation of trifluoromethyl-β-diketones is described, which allows for the synthesis of succinimides and 1,4-diketones through cascade Michael addition/retro-Claisen reaction and nucleophilic substitution/retro-Claisen reaction. The readily available trifluoromethyl-β-diketones, wide substrate scope, and mild conditions make this method very practical.
Synthesis of α,α-difluorobenzoyl oxygen heterocycles via the radical reaction of 2-iodo-2,2-difluoroacetophenones with unsaturated acids or unsaturated alcohols
Chen, Heng,Wang, Jiexiong,Wu, Jingjing,Kuang, Yujia,Wu, Fanhong
, p. 41 - 46 (2017/06/14)
A convenient and facile method for the direct synthesis of α,α-difluorobenzoyl lactones or cyclic ethers via the radical cyclization reaction of 2-iodo-2,2-difluoroacetophenone with unsaturated acids or alcohols was reported.
Palladium-catalyzed direct mono-α-arylation of α-fluoroketones with aryl halides or phenyl triflate
Zhou, Jun,Fang, Xiang,Shao, Tongle,Yang, Xueyan,Wu, Fanhong
supporting information, p. 54 - 62 (2016/10/05)
A palladium catalyzed Negishi-type α-arylation of α-fluoroketones with electron-rich and electron-deficient aryl halides or phenyl triflate has been developed. This direct mono-α-arylation method generate a variety of ternary α-aryl-α-monofluoroketones easily in good to excellent yields using XPhos as ligand and Cs2CO3as mild base.
