41708-72-9 Usage
Uses
Used in Cardiology:
Tocainide is used as an antiarrhythmic agent for the treatment of ventricular arrhythmias and tachycardia. It helps to suppress the symptoms of these conditions by stabilizing the heart's electrical activity and preventing the occurrence of abnormal heart rhythms.
Used in Cardiology for Premature Cardiac Contractions:
Tocainide is also used for the management of premature cardiac contractions, which are extra heartbeats that occur before the next regular heartbeat. By suppressing these premature contractions, Tocainide helps to maintain a regular heart rhythm and prevent complications associated with irregular heartbeats.
Originator
Tonocard,Astra,UK,1981
Manufacturing Process
The compound 2-amino-2',6'-propionoxylidide was synthesized by saturating
with gaseous ammonia at room temperature a suspension of 50 g (0.195 mol)
of 2-bromo-2',6'-propionoxylidide in a mixture of 500 ml of 95% alcohol and
400 ml of concentrated aqueous ammonia. The saturation was carried out
under mechanical stirring. After 25 hours the mixture was resaturated with
ammonia gas. The stirring at room temperature was continued for a total
period of 116 hours, and a sample was taken at that time. Gas
chromatographic analysis indicated that about 95% of the bromo compound
had been converted to the desired product.
The solvents were evaporated in vacuo, and the residue was taken up in 80
ml of 3 M hydrochloric acid. After addition of 220 ml of water, the insoluble
material was filtered off, washed with 100 ml of water and then dried. The
insoluble material weighed 9.5 g and was mainly unreacted bromo compound. The filtrate was reacted with 50 ml of 7 M NaOH, extracted three times with
methylene chloride (50 ml + 2 x 25 ml portions), dried over potassium
carbonate, and then evaporated. The yield of residue was 26.8 g which
corresponds to 71.4% of the theoretical yield. This residue was a colorless
solidifying oil and was dissolved in 200 ml chloroform. Hydrogen chloride was
bubbled in until a sample of the solution tested acidic to wet pH indicator
paper. A precipitate was obtained and recovered by filtration. The precipitate
was washed with chloroform and dried. The melting point was determined to
be from 246°C to 247.5°C.
Therapeutic Function
Antiarrhythmic
World Health Organization (WHO)
Tocainide, an antidysrhythmic agent, was introduced in 1981 for
the treatment of ventricular dysrhythmias. By 1984 its use was associated with
cases of agranulocytosis, aplastic anaemia and thrombocytopenia, some of which
were fatal. This led some regulatory authorities to restrict the indications for its
use. The major manufacturer has subsequently restricted its use on a worldwide
basis to the treatment of symptomatic ventricular dysrhythmias not responding to
other therapy, or when other therapy is contraindicated.
Pharmacokinetics
The α-methyl group is believed to slow the rate of metabolism and, thereby, to
contribute to oral activity. The plasma half-life of tocainide is approximately 12 hours, and nearly
50% of the drug may be excreted unchanged in the urine. Adverse effects associated with tocainide
are like those observed with lidocaine—specifically, gastrointestinal disturbances and central
nervous system effects.
Clinical Use
Tocainide (Tonocard) is an orally effective antiarrhythmic
agent with close structural similarities to lidocaine. Tocainide is indicated for the treatment of symptomatic
ventricular arrhythmias refractory to more conventional
therapy. Serious noncardiac adverse effects limit its use
to patients with life-threatening arrhythmias.
Side effects
Light-headedness, dizziness, or nausea occurs in approximately
15% of patients, paresthesias and numbness
in 9%, and tremor in 8%.These adverse effects are
generally mild in intensity, transient, and dose related.
Overall, however, approximately 20% of patients prescribed
tocainide discontinue therapy because of such
effects. Serious immune-based side effects, such as pulmonary
fibrosis, have been reported, and blood
dyscrasias, such as agranulocytosis and thrombocytopenia,
may occur in up to 0.2% of patients.
Synthesis
Tocainide, 2-amino-2,6-dimethylpropionanilide (18.1.8), is synthesized by
reacting 2,6-dimethylaniline with 2-bromopropionic acid bromide and subsequent substitution
of the bromine atom in the resulting amide (18.1.7) with an amino group.
Drug interactions
When used with other class IB antiarrhythmic drugs, tocainide
toxicity may be increased without significant
gain in antiarrhythmic efficacy.
Precautions
Patients who are hypersensitive to tocainide or to local
anesthetics of the amide type should not be exposed to
tocainide.The presence of second- or third-degree heart
block in the absence of an artificial pacemaker also contraindicates
the use of tocainide.
Check Digit Verification of cas no
The CAS Registry Mumber 41708-72-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,1,7,0 and 8 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 41708-72:
(7*4)+(6*1)+(5*7)+(4*0)+(3*8)+(2*7)+(1*2)=109
109 % 10 = 9
So 41708-72-9 is a valid CAS Registry Number.
41708-72-9Relevant articles and documents
Primary aminoacylanilides, methods of making the same and use as antiarrhythmic drugs
-
, (2008/06/13)
Primary amino acylanilides of the formula, wherein R1 is selected from the group consisting of hydrogen, methyl, ethyl and propyl, R2 is selected from the group consisting of methyl, ethyl, chlorine, methoxy and ethoxy, R3 is selected from the group consisting of hydrogen and methyl, R4 is selected from the group consisting of hydrogen, methyl, and a C1 -C4 alkoxy group, R6 is selected from the group consisting of methyl, ethyl, chlorine, methoxy and ethoxy, R7 is hydrogen, methyl or ethyl, R8 is hydrogen, R9 is hydrogen, methyl or ethyl, R10 is hydrogen, and n is 0 or 1, with the provisions that (a) when n is 0, R8 can also be methyl; (b) when n is 1, and R7 is hydrogen, and R9 is hydrogen or methyl, then R10 can also be methyl; (c) when R1 is hydrogen, R2 is methyl, R3 is hydrogen, R6 is methyl, R7 is hydrogen, R8 is hydrogen, and n is 0, then R4 can be ethoxy or propoxy only; (d) when R1 is hydrogen, R2 is methyl, R3, R4, R7 and R8 are hydrogen, and n is 0, then R6 is methoxy, ethoxy, or ethyl only; and the therapeutically acceptable salts thereof. Compounds of this type have been found to be effective longlasting cardiac antiarrhythmic agents, especially when administered by the oral route
