53984-26-2

Basic information

• Product Name: (2R)-N-(2,6-Dimethylphenyl)-2-aminopropanamide
• Synonyms: (2R)-N-(2,6-Dimethylphenyl)-2-aminopropanamide;(R)-2-Amino-N-(2,6-dimethylphenyl)propanamide;[R,(-)]-N-(2,6-Dimethylphenyl)-2-aminopropanamide;R(-)-Tocainide
• CAS NO: 53984-26-2
• Molecular Formula: C₁₁H₁₆N₂O
• Molecular Weight: 192.2575
• Mol File: 53984-26-2.mol

Chemical Properties

• Boiling Point: 330.1°Cat760mmHg
• Flash Point: 153.5°C
• Appearance: /
• Density: 1.094g/cm³
• CAS DataBase Reference: (2R)-N-(2,6-Dimethylphenyl)-2-aminopropanamide(CAS DataBase Reference)
• NIST Chemistry Reference: (2R)-N-(2,6-Dimethylphenyl)-2-aminopropanamide(53984-26-2)
• EPA Substance Registry System: (2R)-N-(2,6-Dimethylphenyl)-2-aminopropanamide(53984-26-2)

Safety Data

• Hazardous Substances Data: 53984-26-2(Hazardous Substances Data)

Upstream product

• 151416-30-7 (+)-(R)-N²-(tert-butoxycarbonyl)-N¹-(2,6-dimethylphenyl)alaninamide 
• 41708-72-9 tocainide 

Relevant articles and documents

Amine Activation: N-Arylamino Acid Amide Synthesis from Isothioureas and Amino Acids

N-arylamino acid amides have been synthesized via a novel method based on N-arylamine activation into isothioureas followed by reaction with amino acids under iron catalysis. The activated N-arylamines are easily prepared using a three-component reaction with commercial reagents, tert-butylisocyanide and S-phenyl benzenethiosulfonate. The protocol shows a broad functional group compatibility, with respect to side chain functionality of the amino acid (e. g. aliphatic and aromatic OH, (hetero)aromatic NH, amide NH, thioether), and the chiral amino acids do not undergo epimerization. The mechanism of the new amide synthesis has been studied. (Figure presented.).

Liquid chromatographic resolution of tocainide and its analogues on a doubly tethered chiral stationary phase based on (+)-(18-Crown-6)-2,3,11,12- tetracarboxylic acid

A doubly tethered chiral stationary phase (CSP) based on (+)-(18-crown-6)-2,3,11,12-tetracarboxylic acid were applied to the liquid chromatographic resolution of racemic tocainide, an antiarrhythmic agent, and its analogues. The chiral recognition efficiency of the doubly tethered CSP for tocainide and its analogues was generally greater than that of the corresponding singly tethered CSP especially in terms of the resolution (RS). The resolution of tocainide and its analogues on the doubly tethered CSP were dependent on the content and the type of the organic and acidic modifiers in aqueous mobile phase and the column temperature. Especially, the retention behaviors of analytes on the doubly tethered CSP with the variation of the content of organic modifier in aqueous mobile phase were opposite to those on the corresponding singly tethered CSP and these opposite retention behaviors were rationalized by the lipophilicity differences of the two CSPs.

COMPOSITIONS AND METHODS FOR CYCLOFRUCTANS AS SEPARATION AGENTS

The present invention relates to derivatized cyclofructan compounds, compositions comprising derivatized cyclofructan compounds, and methods of using compositions comprising derivatized cyclofructan compounds for chromatographic separations of chemical species, including enantiomers. Said compositions may comprise a solid support and/or polymers comprising derivatized cyclofructan compounds.