- PROCESS FOR THE PREPARATION OF F-SERIES PROSTAGLANDINS
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A process for the synthesis and purification of F-series prostaglandin compounds and synthetic intermediates used to prepare them. The synthetic intermediates are solid and may be purified by precipitation and therefore may form the representative F-series prostaglandin compounds such as latanoprost, bimatoprost, fluprostenol, cloprostenol, and substituted analogs therefrom in highly pure forms.
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Page/Page column 47-49
(2011/05/05)
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- Didemnilactones A and B and Neodidemnilactone, Three New Fatty Acid Metabolites Isolated from the Tunicate Didemnum moseleyi (Herdman)
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Three new fatty acid metabolites didemnilactones A (1) and B (2) and neodidemnilactone (3) were isolated from the tunicate Didemnum moseleyi (Herdman).Their structures including absolute stereochemistry were established on the basis of spectral studies an
- Niwa, Haruki,Watanabe, Masaru,Inagaki, Hideaki,Yamada, Kiyoyuki
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p. 7385 - 7400
(2007/10/02)
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- PROSTANOIDS. LIX. ENANTIODIVERGENT SYNTHESIS OF (+)- AND (-)-9,11-DIDESOXY-9,11-ETHANO ANALOGS OF PROSTAGLANDIN ENDOPEROXIDE AND THEIR C15-DIASTEREOMERS
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Schemes are described for the transformation of (-)-(1S,2S,3S,6R,7R,9R)-10,12-dioxatetracyclo3,6.02,7>tridecan-8-one obtained by the hydrogenation of the endo adduct synthesized in the Diels-Alder reaction from levoglucosenon
- Miftakhov, M. S.,Valeev, F. A.,Gaisina, I. N.,Shitikova, O. V.,Sultanmuratova, V. R.,Tolstikov, G. A.
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p. 933 - 943
(2007/10/02)
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- Prostaglandins. 2. Synthesis of Prostaglandin F2α in Optically Active Form from Chiral Precursors
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A synthetic route to optically active prostaglandins is described which use chiral starting materials.Acylation of the bis(magnesiobromide) salt of methyl hemimalonate with (S)-(-)-2-acetoxysuccinyl chloride led to unstable dimethyl (S)-4-acetoxy-3,6-diox
- Johnson, Francis,Paul, K.G.,Favara, Duccio,Ciabatti, Romeo,Guzzi, Umberto
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p. 2190 - 2198
(2007/10/02)
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- A NOVEL APPROACH TO THE SYNTHESIS OF 8-METHYL PROSTAGLANDINS
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A synthesis of 8-methyl prostaglandins is described.Starting from a chiral cyclic keto lactone, C1-homologation with dimethyl oxosulfonium methylide is used as key reaction in the sequence. 8-Methyl prostaglandin C2 and its methyl es
- Schwarz, S.,Weber, G.,Depner, J.,Schaumann, J.,Schick, H.,Welzel, H. P.
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p. 1261 - 1268
(2007/10/02)
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