Fused Thiazoles: Synthesis and Antifungal Activity of 2-Arylidenethiazoloimidazopyridin-3(2H)-ones, 2-Arylidenethiazolobenzimidazol-3(2H)-ones and 6-Arylidenethiazolo-s-triazol-5(6H)-ones
One-pot synthesis of the title compounds (II, IV) starting from 2-mercapto-1H-imidazopyridines (I; X=N), 2-mercaptobenzimidazoles (I; X=CH) or 5-aryl-3-mercapto-1,2,4-triazoles (III) is described.These compounds have been screened for their antifungal activities.
Prasad, A. R.,Rao, A. Narasimha,Ramalingam, T.,Sattur, P. B.
p. 776 - 778
(2007/10/02)
Synthesis of New 2-Substituted Benzylidenethiazolobenzimidazol-3(2H)-ones and Their Biological Activity
2-Substituted benzylidenethiazolobenzimidazol-3(2H)-ones (I-XIV) have been synthesized and found to possess anticonvulsant activity (0-60percent).These compounds also inhibit rat brain monoamine oxidase (MAO) (33.70-98.30percent) and succinate dehydrogenase (SDH) (25.72-78.95percent) in vitro of concentrations 4E-4 M and 6E-4 M, respectively.Structure-activity relationship has been dicussed.
Soni, Namita,Barthwal, J. P.,Gupta, T. K.,Bhalla, T. N.,Parmar, S. S.,Bhargava, K. P.
p. 785 - 788
(2007/10/02)
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