42022-03-7

Basic information

• Product Name: N-NITROSO-D-PROLINE
• Synonyms: N-NITROSO-D-PROLINE;1-Nitroso-D-proline
• CAS NO: 42022-03-7
• Molecular Formula: C5H8N2O3
• Molecular Weight: 144.12862
• Product Categories: Amino Acids 13C, 2H, 15N;Amino Acids & Derivatives;Heterocycles;Mutagenesis Research Chemicals
• Mol File: 42022-03-7.mol

Chemical Properties

• Melting Point: 109-110°C
• Boiling Point: 391.692°C at 760 mmHg
• Flash Point: 190.688°C
• Appearance: /
• Density: 1.572g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.629
• Storage Temp.: Refrigerator
• Solubility: Chloroform, Methanol, Water
• CAS DataBase Reference: N-NITROSO-D-PROLINE(CAS DataBase Reference)
• NIST Chemistry Reference: N-NITROSO-D-PROLINE(42022-03-7)
• EPA Substance Registry System: N-NITROSO-D-PROLINE(42022-03-7)

Safety Data

• Hazardous Substances Data: 42022-03-7(Hazardous Substances Data)

Usage

Uses

N-NITROSO-D-PROLINE is used as a research chemical for studying the mechanisms of carcinogenesis and the effects of nitrosamines on biological systems. Its oncogenic properties make it a valuable tool for understanding the development of cancer and the factors that contribute to its progression.
Used in Pharmaceutical Research:
N-NITROSO-D-PROLINE is used as a pharmaceutical research compound for investigating the role of nitrosoamino acids in the etiology of cancer and for developing potential therapeutic agents to counteract their effects.
Used in Toxicological Studies:
N-NITROSO-D-PROLINE is used as a toxicological agent in studies aimed at understanding the dose-response relationship and the potential health risks associated with exposure to nitrosamines.

InChI:InChI=1/C5H8N2O3/c8-5(9)4-2-1-3-7(4)6-10/h4H,1-3H2,(H,8,9)/t4-/m1/s1

Upstream product

• 147-85-3 L-proline 
• 344-25-2 D-Prolin 

Downstream Products

• 98262-66-9 3a,4,5,6-tetrahydro-3-oxo-3H-pyrrolo[1,2-c][1,2,3]oxadiazol-7-ium ylide 
• 102608-17-3 N-trifluoroacetylamino-2-pyrrolidone 

Relevant articles and documents

Versatile new reagent for nitrosation under mild conditions

Here we report a new chemical reagent for transnitrosation under mild experimental conditions. This new reagent is stable to air and moisture across a broad range of temperatures and is effective for transnitrosation in multiple solvents. Compared with traditional nitrosation methods, our reagent shows high functional group tolerance for substrates that are susceptible to oxidation or reversible transnitrosation. Several challenging nitroso compounds are accessed here for the first time, including 15N isotopologues. X-ray data confirm that two rotational isomers of the reagent are configurationally stable at room temperature, although only one isomer is effective for transnitrosation. Computational analysis describes the energetics of rotamer interconversion, including interesting geometry-dependent hybridization effects.

NITROSATION REAGENTS AND METHODS

Provided are compounds that can find use as nitrosation reagents. Provided are nitrosation methods that include reacting a substrate with one of the provided nitrosation reagents and thereby generating a nitrosation product. Provided are kits including a nitrosation reagent. Provided are compositions wherein the nitrosation reagent is enriched in the 15N isotope.

Big ring indole used as MCL-1 inhibitor

The invention provides a compound represented by a formula (I) and a pharmaceutical salt and solvate thereof. In the formula (I), the definitions of R, R1a, R1b, R1h, L1, L2, and L3 are shown in the description. The invention also provides a compound represented by the formula (I), and the compound can be used to treat disease or disorder related with MCL-1 inhibition, such as cancers.