- Total Synthesis of Aromatic Steroids
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The coupling reaction of m-methoxystyrene (1) and 4-bromo-1-diazo-2-butanone (2) over Pd(OAc)2 gave trans and cis (ratio 7:1) cyclopropane derivatives 3a and 3b, which were used for the alkylation of 2-methylcyclopentane-1,3-dione to afford triketones 4a
- Daniewski, Andrzej Robert,Kowalczyk-Przewloka, Teresa
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p. 2976 - 2980
(2007/10/02)
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- A HIGHLY CONVERGENT AND FLEXIBLE STRATEGY FOR THE SYNTHESIS OF A-RING AROMATIC STEROIDS
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Using Hendrickson's criteria for systematic synthesis design, a strategy featuring a linear six carbon synthon (7) for bis-annulation has been devised for economic, flexible and highly convergent syntheses of A-ring aromatic steroids.
- Mander, Lewis N.,Turner, John V.
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p. 3683 - 3686
(2007/10/02)
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- Synthesis of gon-4-enes
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1. A therapeutic composition having progestational activity comprising as active ingredient a 17-aliphatic carboxylic acid ester of 17α-ethynyl-18-methyl-19-nortestosterone and a pharmaceutical carrier for said compound.
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- Synthesis of 13-alkyl-gon-4-ones
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The preparation of 13-methylgon-4-enes and novel 13-polycarbonalkylgon-4-enes by a new total synthesis is described. 13-Alkylgon-4-enes having progestational, anabolic and androgenic activities are prepared by forming a tetracylic gonane structure unsaturated in the 1,3,5(10),9(11) and 14-positions, selectively reducing in the B- and C-rings, and converting the aromatic A-ring compounds so-produced to gon-4-enes by Birch reduction and hydrolysis.
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