- Supramolecular Anchoring of NCN-Pincer Palladium Complexes into a β-Barrel Protein Host: Molecular-Docking and Reactivity Insights
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Several prochiral NCN-pincer complexes of palladium(II), with hemilabile ligands and a long aliphatic chain, were synthesized and characterized spectroscopically. In some of the complexes, the presence of two different substituents on the N donor atoms ma
- Pocquet, Lucrèce,Vologdin, Nikolay,Mangiatordi, Giuseppe Felice,Ciofini, Ilaria,Nicolotti, Orazio,Thorimbert, Serge,Salmain, Michèle
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- A saponification-triggered gelation of ester-based Zn(ii) complex through conformational transformations
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Novel saponification-triggered gelation in an ester-based bis-salen Zn(ii) complex (1) is described. Strategic structural modifications induced by NaOH in 1 tune the dipolar-/π-interactions leading to J-aggregation and the creation of an inorganic gel mat
- Kumar, Ashish,Dubey, Mrigendra,Kumar, Amit,Pandey, Daya Shankar
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Read Online
- A new double layered 2-D copper(II) coordination polymer based on a semi-rigid ligand
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A new 2-D Cu(II) coordination polymer, [Cu2(L)(H2O)3]·4.5H2O (1) [H4L?=?5,5′-(pyrazine-2,3-diylbis(azanediyl))diisophthalic acid], has been synthesized from the reaction of Cu(NO3)2/s
- Yan, Shichen,Ju, Zhanfeng,Yuan, Daqiang
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Read Online
- Defect-Engineered Chiral Metal-Organic Frameworks for Efficient Asymmetric Aldol Reaction
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By employment of a mixed truncated chiral ligand synthetic strategy, a defect-engineered chiral metal-organic framework with hierarchical micro/mesoporous structure was prepared, and it exhibited efficient heterogeneous catalytic activity and enantioselectivity for asymmetric aldol reaction.
- Chen, Zijuan,Yan, Xiaodan,Li, Meiyan,Wang, Shuhua,Chen, Chao
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supporting information
p. 4362 - 4365
(2021/05/04)
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- “Orthogonal-Twisted-Arm” Ligands for The Construction of Metal–Organic Frameworks (MOFs): New Topology and Catalytic Reactivity
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Extended tetratopic benzoic acid ligands with “orthogonal-twisted-arms” conformations were designed and synthesized for the construction of new MOF structures (OTA-MOF). Upon coordination with Cd2+ and Cu2+ cations, two well-defined new MOFs were prepared. X-ray single crystal structures were successfully obtained, demonstrating the formation of a new topology (4,4,4-c). The OTA2-MOF-Cu gave moderate stability in organic solvents and good gas sorption ability toward CO2. This new MOF showed superior catalytic reactivity toward the epoxide-CO2 cycloaddition, giving >50 folds yield enhancement over the controlled reaction without MOF. It is expected that this new ligand design, porous structure, and excellent CO2 catalytic reactivity will make OTA-MOF promising new materials for applications in catalysis and separation.
- He, Ying,Li, Guanghua,Ren, Junyu,Shan, Chuan,Shi, Xiaodong,Song, Zhiguang,Wang, Li,Wojtas, Lukasz,Zhao, Kai
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supporting information
p. 16272 - 16276
(2020/11/30)
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- Azo aryl urea derivative, and preparation method and application thereof
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The invention relates to an azo aryl urea derivative, and a preparation and an application thereof, and concretely discloses a compound represented by formula (I), or an optical isomer, a cis-trans-isomer or a pharmaceutically acceptable salt thereof, and a preparation method thereof. Definitions of substituent groups in the general formula are described in the specification and claims. The invention further discloses a composition containing the above compound, and an application thereof. The compound has excellent anticancer activity on HepG2 liver cancer cells, MGC803 gastric cancer cells,HCT116 colon cancer and the like.
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Paragraph 0117-0118; 0119-0120
(2020/06/17)
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- A charged metal-organic framework for CO2/CH4 and CO2/N2 separation
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A microporous metal-organic framework [InL][(CH3)2NH2]·(H4L = 9-(3,5-dicarboxyphenyl)carbazole-3,6-dicarboxylic acid) (1) was hydrothermally synthesized and structurally characterized by single crystal X-ray dif
- Zhong, Ruiqin,Xu, Zhilong,Bi, Wenzhu,Han, Songbai,Yu, Xiaofeng,Zou, Ruqiang
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supporting information
p. 299 - 303
(2016/02/05)
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- Monocrystalline iron metal organic frameworks
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The invention relates to large single crystals of iron metal-organic framework materials comprising at least one iron metal ion, processes for preparing the same, methods for employing the same, and the use thereof. The invention also relates to monocrystalline and polycrystalline iron metal-organic frameworks.
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Paragraph 0171; 0172
(2015/06/03)
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- Aluminum Metal Organic Framework Materials
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The invention relates to monocrystalline single crystals of metal-organic framework materials comprising at least one aluminium metal ion, processes for preparing the same, methods for employing the same, and the use thereof. The invention also relates to monocrystalline aluminium metal-organic frameworks.
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Paragraph 0170; 0171; 0172
(2019/07/30)
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- Photoswitchable thioureas for the external manipulation of catalytic activity
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A series of azobenzene-based thiourea catalysts have been developed with the aim of achieving control over the catalytic activity by the use of light. The conceptual design of these systems relies on the inactivation by means of intramolecular hydrogen bonding, only likely to take place in one of their isomeric forms. After fine structure modulation of the catalyst a substantial difference in activity has been observed between the irradiated and the nonirradiated reaction. Furthermore, the system allowed in situ manipulation of the catalyst activity during the course of a given experiment.
- Osorio-Planes, Laura,Rodriguez-Escrich, Carles,Pericas, Miquel A.
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supporting information
p. 1704 - 1707
(2014/04/17)
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- Zinc metal-organic frameworks based on a flexible benzylaminetetracarboxylic acid and bipyridine colinkers
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Three new metal-organic frameworks (MOFs), [Zn2(L)(H 2O)]·3DMF·1.5H2O (1), [Zn 2(L)(4,4-bpy)1.5(H2O)2] ·2DMF·2H2O (2), and [Zn2(L)(2,2-bpy) 2(DMF)2]·2DMF·4H2O (3) [H 4L = 5,5-(2,3,5,6-tetramethyl-1,4-phenylene)bis(methylene) bis(azanediyl)diisophthalic acid, 4,4-bpy = 4,4-bipyridine, 2,2-bpy = 2,2-bipyridine, DMF = N,N-dimethylformamide], were synthesized under solvothermal conditions and characterized by single-crystal X-ray diffraction analysis, elemental analysis, IR spectroscopy, powder X-ray diffraction (PXRD), and thermogravimetric analysis (TGA). The L4- ligands in 1-3 display different coordination modes, and the introduction of bipyridine colinkers brings significant structural variation into the frameworks. Complex 1 is constructed from dinuclear carboxylate [Zn2O(COO)4] secondary building units (SBUs) and H4L ligands and exhibits a binodal (4,4)-connected pts net with 54.6 % solvent-accessible void. Complex 2 exhibits an unprecedented tetranodal (3,4,4,4)-connected net, which is constructed from two types of crystallographically independent ZnII ions, H4L ligands, and the 4,4-bipyridine colinker. Complex 3 is constructed from parallel 1D molecular ladders stacked along the a axis that generate 1D channels (7.8 × 10.4 A?) and are hydrogen bonded to form 2D layers. The thermal stabilities and luminescence properties of 1-3 have also been studied in detail. Copyright
- Wang, Chao,Tang, Sifu,Lv, Xiaoxia,Li, Liangjun,Zhao, Xuebo
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p. 3133 - 3139
(2014/07/21)
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- Zinc Metal-Organic Frameworks Based on a Flexible Benzylaminetetracarboxylic Acid and Bipyridine Colinkers
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Three new metal-organic frameworks (MOFs), [Zn2(L)(H2O)]·3DMF·1.5H2O (1), [Zn2(L)(4,4′-bpy)1.5(H2O)2]·2DMF·2H2O (2), and [Zn2(L)(2,2′-bpy)2(DMF)2]·2DMF·4H2O (3) [H4L = 5,5′-(2,3,5,6-tetramethyl-1,4-phenylene)bis(methylene)bis(azanediyl)diisophthalic acid, 4,4′-bpy = 4,4′-bipyridine, 2,2′-bpy = 2,2′-bipyridine, DMF = N,N-dimethylformamide], were synthesized under solvothermal conditions and characterized by single-crystal X-ray diffraction analysis, elemental analysis, IR spectroscopy, powder X-ray diffraction (PXRD), and thermogravimetric analysis (TGA). The L4- ligands in 1-3 display different coordination modes, and the introduction of bipyridine colinkers brings significant structural variation into the frameworks. Complex 1 is constructed from dinuclear carboxylate [Zn2O(COO)4] secondary building units (SBUs) and H4L ligands and exhibits a binodal (4,4)-connected pts net with 54.6% solvent-accessible void. Complex 2 exhibits an unprecedented tetranodal (3,4,4,4)-connected net, which is constructed from two types of crystallographically independent ZnII ions, H4L ligands, and the 4,4′-bipyridine colinker. Complex 3 is constructed from parallel 1D molecular ladders stacked along the a axis that generate 1D channels (7.8 × 10.4 ?) and are hydrogen bonded to form 2D layers. The thermal stabilities and luminescence properties of 1-3 have also been studied in detail.
- Wang, Chao,Tang, Sifu,Lv, Xiaoxia,Li, Liangjun,Zhao, Xuebo
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p. 3133 - 3139
(2015/04/27)
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- A schiff base and its copper(II) complex as a highly selective chemodosimeter for mercury(II) involving preferential hydrolysis of aldimine over an ester group
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The syntheses of a new Schiff base, diethyl-5-(2-hydroxybenzylidene) aminoisophthalate (HL), and a copper complex, [Cu(L2)] (1), imparting L-, have been described. Both the ligand HL and complex 1 have been thoroughly characterized b
- Kumar, Ashish,Dubey, Mrigendra,Pandey, Rampal,Gupta, Rakesh Kumar,Kumar, Amit,Kalita, Alok Ch.,Pandey, Daya Shankar
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p. 4944 - 4955
(2014/06/09)
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- The role of magnetic nanoparticles (MNP) as reducing agents in an MNP-supported Pd-catalyst for the reductive homocoupling of aryl halides
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A palladium pincer catalyst grafted onto the surface of magnetic nanoparticles (MNPs) has been developed. This material effectively catalyzes the reductive homocoupling of various aryl halide substrates, with the MNP support acting as the reducing agent. The catalyst can be recycled up to five times in the absence of additional reducing agent to give almost quantitative yields of biaryl homocoupling products. After the reducing power of the MNP has been depleted, the supported Pd complex remains an effective catalyst for Suzuki-Miyaura cross-coupling.
- Zheng, Jie,Lin, Shengyue,Jiang, Bi-Wang,Marder, Todd B.,Yang, Zhen
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supporting information; experimental part
p. 138 - 144
(2012/03/07)
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- BIPHENYL-4-YL-SULFONIC ACID ARYLAMIDES AND THEIR USE AS THERAPEUTIC AGENTS
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The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain aryl sulfonamides and related compounds (collectively referred to herein as "BPSAAA compounds"), as described herein, and including, for example, biphenyl-4-sulfonic acid (hydroxyalkyl-phenyl)-amides and related compounds. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, in treatment and/or prevention, for example, of inflammation and/or joint destruction and/or bone loss; of disorders mediated by excessive and/or inappropriate and/or prolonged activation of the immune system; of, inflammatory and autoimmune disorders, for example, rheumatoid arthritis, psoriasis, psoriatic arthritis, chronic obstructive pulmonary disease (COPD), atherosclerosis, inflammatory bowel disease, ankylosing spondylitis, and the like; of disorders associated with bone loss, such as bone loss associated with excessive osteoclast activation in rheumatoid arthritis, osteoporosis, cancer associated bone disease, Paget's disease and the like.
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Page/Page column 65-66
(2008/12/07)
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- Fluorescence resonance energy transfer across a mechanical bond of a rotaxane
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Fluorescence transfer across a donor-acceptor tagged rotaxane was studied and a small conformational change of the rotaxane observed using fluorescent spectroscopy and ROESY NMR. The Royal Society of Chemistry 2005.
- Onagi, Hideki,Rebek Jr., Julius
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p. 4604 - 4606
(2007/10/03)
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- A highly efficient light-emitting poly{[5-(diphenylamino)-1,3- phenylenevinylene]-alt-(2,5-dihexyloxy-1,4-phenylenevinylene)}: Synthesis and optical properties
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The improvement in efficiency of LED's by making a transport layer between emitter and cathode and a hole transporting layer between emitter and anode was discussed. Triphenylamine (TPA) was used as hole transport layer in OLED. For the improvment in the
- Liao, Liang,Pang, Yi,Ding, Liming,Karasz, Frank E.
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p. 3970 - 3972
(2007/10/03)
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- Tetrahedral onsager crosses for solubility improvement and crystallization bypass
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Pure organic molecules exhibiting a suitable concave rigid shape are expected to give porous glasses in the solid state. Such a feature opens new opportunities to avoid crystallization and to improve molecular solubility in relation to the high internal energy of these solid phases. To quantitatively explore the latter strategy, a series of rigid tetrahedral conjugated molecules nC and the corresponding models nR have been synthesized. Related to the present purpose, several properties have been investigated using UV absorption, steady-state fluorescence emission, differential scanning calorimetry, 1H NMR translational self-diffusion, magic angle spinning 13C NMR, and multiple-beam interferometry experiments. The present tetrahedral crosses are up to 8 orders of magnitude more soluble than the corresponding model compounds after normalization to the same molecular length. In addition, they give concentrated monomeric solutions that can be used to cover surfaces with homogeneous films whose thickness goes down to the nanometer range. Such attractive features make cross-like molecular architectures promising for many applications.
- Aujard,Baltaze,Baudin,Cogne,Ferrage,Jullien,Perez,Prevost,Lin Mao Qian,Ruel
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p. 8177 - 8188
(2007/10/03)
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- Synthesis of achiral linker reagents for direct labelling of oligonucleotides on solid supports
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Full experimental procedures for the synthesis of a series of new functional linker reagents (14-16) and solid supports (11-13) are reported. The achiral linker reagents and supports can be used for high yield incorporation of free amino groups, fluorescein or biotin into DNA oligomers.
- Behrens, Carsten,Dahl, Otto
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p. 291 - 305
(2007/10/03)
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- Tridentate SCS palladium(II) complexes: New, highly stable, recyclable catalysts for the Heck reaction
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A new pincer-type SCS ligand containing Pd(II) is a simple, robust catalyst for Heck chemistry using a variety of alkene acceptors and aryl iodides. It is less active with aryl bromides. While certain palladium-(II) species insert slowly into the aryl C-H bond of an unsubstituted version of this ligand, the introduction of activating groups into the 5 position of the aromatic ring readily allows quantitative metal insertion. These ligands were synthesized and attached to soluble polymers by simple modification of inexpensive starting materials. For example, both 5-oxy and 5-amido SCS ligands were successfully appended to 5000 Mn poly-(ethylene glycol) via ether or amide linkages, respectively. Both the 5-oxo and 5-amido complexes are active as Heck catalysts in DMF solution in air. The PEG-bound 5-amido-SCS-Pd complex was recycled via solvent precipitation three times with no observed catalyst deactivation. While the 5-amido-SCS-Pd complexes are very robust, their 5-oxo counterparts decompose slowly under certain conditions. These SCS catalysts are analogous to PCP-type catalysts previously reported in the literature but avoid the requirement of an air-sensitive phosphine synthesis.
- Bergbreiter, David E.,Osburn, Philip L.,Liu, Yun-Shan
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p. 9531 - 9538
(2007/10/03)
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- THE INHIBITION OF GLUTAMATE DEHYDROGENASE BY DERIVATIVES OF ISOPHTHALIC ACID
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A range of compounds, structurally related to glutamate, have been tested as inhibitors of pea leaf glutamate dehydrogenase assayed in either direction.Only 5-N-substituted derivatives of aminoisophthalic acid completely inhibited the enzyme when tested at concentrations equal to either those of 2-oxoglutarate or glutamate.A minimum of three carbon atoms attached linearly to the amino group was required for maximum inhibition, inhibition was removed if there was any substitution on the first carbon.The 5-N-substituted derivatives also inhibited yeast (to a greater extent) and bovine liver (to a lesser extent) glutamate dehydrogenases.Key Word Index - Pisum sativum; Leguminoseae; yeast; bovine; glutamate dehydrogenase inhibition; isophthalic acid derivatives.
- Cunliffe, Denise,Leason, Mark,Parkin, Donald,Lea, Peter J.
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p. 1357 - 1360
(2007/10/02)
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