- Synthesis of imidazolidin-2-ones employing dialkyl carbonates as an ecofriendly carbonylation source
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A new approach to the synthesis of imidazolidin-2-ones by carbonylation of vicinal diamines with dialkyl carbonates using Pb(NO3)2 and Cu(ii) salts as catalysts has been described in the present protocol. A comparative study using Cu(ii) salts and Pb(NO3)2 as catalysts has suggested Cu(NO3)2 and CuCl 2·2H2O salts to be as promising as Pb(NO 3)2 and can replace the latter in the carbonylation reactions employing dialkyl carbonates. the Partner Organisations 2014.
- Badru, Rahul,Singh, Baldev
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p. 38978 - 38985
(2014/11/07)
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- Highly active and selective supported iron oxide nanoparticles in microwave-assisted N-alkylations of amines with alcohols
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Highly active and stable supported iron oxide nanoparticles show excellent activities and switchable selectivities to target products in the microwave-assisted N-alkylation of amines with alcohols. The Royal Society of Chemistry 2010.
- Gonzalez-Arellano, Camino,Yoshida, Kenta,Luque, Rafael,Gai, Pratibha L.
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experimental part
p. 1281 - 1287
(2010/10/04)
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- NOVEL COMPOUNDS
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The present invention relates to compounds and derivatives thereof, their synthesis, and their use as glucocorticoid receptor modulators. The compounds of the instant invention are ligands for glucocorticoid receptors and as such may be useful for treatment or prevention of a variety of conditions related to glucocorticoid functioning including rheumatoid arthritis, osteoarthritis, allery, asthma, pneumonia, dermatitis, eczema, psoriasis, lupus, colitis, inflammatory bowel disease, multiple sclerosis, congenital neutropenia, Wegener's granulomatosis, Addison's Disease, Crohn's disease Cushing Syndrome, or as immunosuppressants in organ transplantation.
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Page/Page column 23
(2010/02/07)
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- Design, synthesis, and pharmacological evaluation of conformationally constrained analogues of N,N'-diaryl- and N-aryl-N-aralkylguanidines as potent inhibitors of neuronal Na+ channels
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In the present investigation, the rationale for the design, synthesis, and biological evaluation of potent inhibitors of neuronal Na+ channels is described. N,N'-Diaryl- and N-aryl-Naralkylguanidine templates were locked in conformations mimick
- Maillard, Michel C.,Perlman, Michael E.,Amitay, Oved,Baxter, Deborah,Berlove, David,Connaughton, Sonia,Fischer, James B.,Guo, Jun Qing,Hu, Lain-Yen,McBurney, Robert N.,Nagy, Peter I.,Subbarao, Katragadda,Yost, Elizabeth A.,Zhang, Lu,Durant, Graham J.
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p. 3048 - 3061
(2007/10/03)
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- A Convenient Synthesis of 1,2,5-Trisubstituted 4,5-Dihydroimidazoles and 1,3-Diazaspiroalk-2-enes from N-Alkylideneanilines
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A convenient synthesis of 5-aryl-4,5-dihydro-2-methoxycarbonylamino-1-phenylimidazoles 5a-d and 2-methoxycarbonylamino-1-phenyl-1,3-diazaspiroalk-2-enes 5e,f has been reported from N-alkylideneanilines 1a-f via cyclization of the corresponding 1,2
- Naim, S. Shawkat,Sharma, Satyavan
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p. 664 - 666
(2007/10/02)
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- ACAT inhibitors
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This invention relates to novel compounds which are ACAT inhibitors rendering them useful in lowering blood cholesterol levels. The compounds contain two urea or thiourea, amide, or amine moieties or combinations of said moieties and have the following general formula: wherein Ar is an aryl group, m and n are zero or one,W and YNH and form the urea, thiourea, amide or amine moieties.
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- MODELS OF FOLATE COENZYMES 16. CHEMICAL MODELLING OF THE THYMIDYLATE SYNTHASE REACTION. EVIDENCE FOR AN "EXOCYCLIC METHYLENE INTERMEDIATE" ANALOGUE, WHICH IS REDUCIBLE TO A THYMINE DERIVATIVE, IN THE REACTION OF 6-AMINOURACILS WITH A 5,10-METHYLENETETRAHY
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Reactions of 6-amino-, 6-alkylamino-, and 6-anilino-1,3-dimethyluracils (1a-1e) with 3,4-diphenyl-1-tosylimidazolidine (2), in the presence of acid, lead to the formation of products which are derived from an "exocyclic methylene intermediate" analogous t
- Meij, Paul F. C. van der,Lohmann, Ruth D.,Waard, Eduard R. De,Chen, Tjoe B. R. A.,Pandit, Upendra K.
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p. 3921 - 3930
(2007/10/02)
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