42182-65-0

Basic information

• Product Name: 1,3-BENZOTHIAZOL-2-YLMETHYLAMINE HYDROCHLORIDE
• Synonyms: BUTTPARK 154\06-16;BENZOTHIAZOL-2-YLMETHYLAMINE HCL;1,3-BENZOTHIAZOL-2-YLMETHYLAMINE HYDROCHLORIDE;2-Benzothiazolemethanamine(9CI);(1,3-benzothiazol-2-ylmethyl)amine(SALTDATA: HCl);2-BenzothiazoleMethanaMine;2-(Aminomethyl)benzothiazole;NSC 509752
• CAS NO: 42182-65-0
• Molecular Formula: C₈H₈N₂S
• Molecular Weight: 200.69
• Product Categories: BENZOTHIAZOLE
• Mol File: 42182-65-0.mol

Chemical Properties

• Melting Point: 125-127℃
• Boiling Point: 282℃
• Flash Point: 124℃
• Appearance: /
• Density: 1.300
• Vapor Pressure: 0.00344mmHg at 25°C
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 7.34±0.29(Predicted)
• CAS DataBase Reference: 1,3-BENZOTHIAZOL-2-YLMETHYLAMINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-BENZOTHIAZOL-2-YLMETHYLAMINE HYDROCHLORIDE(42182-65-0)
• EPA Substance Registry System: 1,3-BENZOTHIAZOL-2-YLMETHYLAMINE HYDROCHLORIDE(42182-65-0)

Safety Data

• Hazardous Substances Data: 42182-65-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1,3-Benzothiazol-2-ylmethylamine hydrochloride is used as an intermediate in the synthesis of various pharmaceuticals for its unique chemical properties that contribute to the development of new drugs.
Used in Agrochemical Industry:
1,3-BENZOTHIAZOL-2-YLMETHYLAMINE HYDROCHLORIDE is also used as an intermediate in the synthesis of agrochemicals, where its unique properties can be leveraged to create effective products for agricultural applications.
Used as a Corrosion Inhibitor:
1,3-Benzothiazol-2-ylmethylamine hydrochloride has been studied for its potential as a corrosion inhibitor, which can be utilized in various industries to protect materials from degradation.
Used as an Antioxidant:
Additionally, this compound has been researched for its potential as an antioxidant, which can be beneficial in various applications where protection against oxidative damage is required.
Safety and Handling:
1,3-Benzothiazol-2-ylmethylamine hydrochloride should be handled and stored according to proper safety and handling guidelines, as it may be harmful if ingested, inhaled, or comes into contact with the skin.

InChI:InChI=1/C8H8N2S/c9-5-8-10-6-3-1-2-4-7(6)11-8/h1-4H,5,9H2/p+1

Upstream product

• 106086-78-6 2-(bromomethyl)-1,3-benzothiazole 
• 22918-12-3 2-nitromethylbenzothiazole 
• 42182-64-9 2-Acetamidomethylbenzothiazol 
• 29182-25-0 Amino--essigsaeure 
• 202992-18-5 2-(benzo[d]thiazol-2-ylmethyl)isoindoline-1,3-dione 
• 95-16-9 1,3-Benzothiazole 
• 137-07-5 2-amino-benzenethiol 
• 29182-42-1 ethyl 2-(2-benzothiazolyl)acetate 
• 29389-34-2 benzothiazol-2-yl-(E)-hydroxyimino-acetic acid 
• 29169-60-6 benzothiazol-2-yl-(Z)-hydroxyimino-acetic acid ethyl ester 
• 1028436-75-0 benzyl (benzo[d]thiazol-2-yl)methylcarbamate 
• 6639-57-2 benzothiazole-2-carbaldehyde 
• 1129-05-1 benzo[b]thiazole-2-carbaldehyde oxime 

Downstream Products

• 1028436-90-9 C₃₄H₃₈N₄O₅S 
• 530090-31-4 (Z)-N-(1,3-benzothiazol-2-ylmethyl)-2-{1-[2-chloro-4-(3-methyl-1H-pyrazol-1-yl)benzoyl]-4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-ylidene}acetamide 
• 1203604-12-9 4-{3-[(1,3-benzothiazol-2-ylmethyl)amino]-1,2,4-triazin-5-yl}-3-methylphenol 
• 1388625-38-4 2-(benzothiazol-2-yl)-5-phenyloxazole 
• 1040257-30-4 [5-(1,3-benzothiazol-2-yl)-1H-pyrrol-3-yl](2-hydroxyphenyl)methanone 
• 101874-65-1 3-benzothiazol-2-ylmethyl-5-benzylidene-2-thioxo-thiazolidin-4-one 
• 117998-90-0 N-(1,3-benzothiazol-2-ylmethyl)benzamide 
• 42182-64-9 2-Acetamidomethylbenzothiazol 
• 1203603-80-8 N-(1,3-benzothiazol-2-ylmethyl)-5-(2,6-dimethoxyphenyl)-1,2,4-triazin-3-amine 

Relevant articles and documents

Benzothiazole-oxazole type alpha-glucosidase inhibitor and preparation method and application thereof

The invention discloses a benzothiazole-oxazole type alpha-glucosidase inhibitor and a preparation method and application thereof. The method comprises the following steps: adding a compound (II) andhydroxylamine hydrochloride in a methanol aqueous solution and a sodium carbonate aqueous solution to obtain a compound (III); adding the compound (III), zinc powder and ammonium formate in methanol and reacting to obtain a compound (IV); and adding the compound (IV), a compound (V), iodine and potassium carbonate in DMF and reacting to obtain a compound (I). The chemical formula of the compound (I) is as shown in specification, the chemical formula of the compound (II) is as shown in specification, the chemical formula of the compound (III) is as shown in specification, the chemical formula of the compound (IV) is as shown in specification, and the chemical formula of the compound (V) is as shown in specification. The benzothiazole-oxazole type compound has obvious inhibition effect on alpha-glucosidase, the preparation method is simple, reaction conditions are gentle, and thus, the benzothiazole-oxazole type alpha-glucosidase inhibitor is suitable for being industrially produced on alarge scale.

Role of benzimidazole (Bid) in the δ-opioid agonist pseudopeptide H-Dmt-Tic-NH-CH2-Bid (UFP-502)

H-Dmt-Tic-NH-CH2-Bid (UFP-502) was the first δ-opioid agonist prepared from the Dmt-Tic pharmacophore. It showed interesting pharmacological properties, such as stimulation of mRNA BDNF expression and antidepression. To evaluate the importance of 1H-benzimidazol-2-yl (Bid) in the induction of δ-agonism, it was substituted by similar heterocycles: The substitution of NH(1) by O or S transforms the reference δ-agonist into δ-antagonists. Phenyl ring of benzimidazole is not important for δ-agonism; in fact 1H-imidazole-2-yl retains δ-agonist activity.

Phenylimidazole derivatives as specific inhibitors of bacterial enoyl-acyl carrier protein reductase FabK

Bacterial enoyl-acyl carrier protein (ACP) reductases (FabI and FabK) catalyze the final step in each cycle of bacterial fatty acid biosynthesis and are attractive targets for the development of new antibacterial agents. Here, we report the development of novel FabK inhibitors with antibacterial activity against Streptococcus pneumoniae. Based on structure-activity relationship (SAR) studies of our screening hits, we have developed novel phenylimidazole derivatives as potent FabK inhibitors.

Thiazole derivative

A thiazole compound of the formula: STR1 wherein T is lower alkylene; u is 0 or 1; R1 and R2 are the same or different and are each H, or lower alkyl, etc.; R3 is STR2 R4 is H or lower alkanoyloxy-lower alkyl, which shows inhibitory activity on protein kinase C (PKC, Ca2+ /phospholipid-depending serine/threonine protein phosphatase), and are useful as a protein kinase C inhibitor.